Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells

Cancer Letters

Volumn 235, Issue 1, 2006, Pages 141-146

  Liu, Fuli ^a   Cheng, Yajun ^a   Wu, Jun ^a   Tauschel, Horst Dietmar ^b   Duan, Rui Dong ^a  

^a LUND UNIVERSITY   (Sweden)

^b Dr Falk Pharma GmbH   (Germany)

Author keywords

Caco 2 cells; Colon cancer; Sphingomyelinase; UDCA

Indexed keywords

CASPASE 3; SPHINGOMYELIN PHOSPHODIESTERASE; URSODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CULTURE; CELL DIFFERENTIATION; CELL POLARITY; CELL PROLIFERATION; CELL STRAIN CACO 2; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CACO-2 CELLS; CASPASE 3; CASPASES; CELL PROLIFERATION; CHOLAGOGUES AND CHOLERETICS; HUMANS; SPHINGOMYELIN PHOSPHODIESTERASE; URSODEOXYCHOLIC ACID;

EID: 33646156070     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.04.016     Document Type: Article

References (25)

1. Earnest D.L., Holubec H., Wali R.K., Jolley C.S., Bissonette M., Bhattacharyya A.K., et al. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 54 (1994) 5071-5074
2. Ikegami T., Matsuzaki Y., Shoda J., Kano M., Hirabayashi N., and Tanaka N. The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue. Cancer Lett. 134 (1998) 129-139
3. Pardi D.S., Loftus E.V., Kremers W.K., Keach J., and Lindor K.D. Ursodeoxyc holic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 124 (2003) 889-893
4. Wali R.K., Khare S., Tretiakova M., Cohen G., Nguyen L., Hart J., et al. Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. Cancer Epidemiol. Biomarkers Prev. 11 (2002) 1653-1662
5. Khare S., Cerda S., Wali R.K., von Lintig F.C., Tretiakova M., Joseph L., et al. Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. Cancer Res. 63 (2003) 3517-3523
6. Hannun Y.A., and Bell R.M. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243 (1989) 500-507
7. Kolesnick R.K. Sphingomyelin and derivatives as cellular signals. Prog. Lipid Res. 30 (1991) 1-38
8. Brasitus T.A., Dudeja P.K., and Dahiya R. Premalignant alterations in the lipid composition and fluidity of colonic brush border membranes of rats administered 1,2 dimethylhydrazine. J. Clin. Invest. 77 (1986) 831-840
9. Selzner M., Bielawska A., Morse M.A., Rudiger H.A., Sindram D., Hannun Y.A., and Clavien P.A. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 61 (2001) 1233-1240
10. Vesper H., Schmelz E.M., Nikolova-Karakashian M.N., Dillehay D.L., Lynch D.V., and Merrill Jr. A.H. Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129 (1999) 1239-1250
11. Nilsson Å., Hertervig E., and Duan R.D. Digestion and absorption of sphingolipids in food. In: van Nieuwenhuyzen W. (Ed). Nutrition and Biochemistry of Phospholipids (2003), AOCS Press, Champaign, IL 70-79
12. Nilsson Å. The presence of sphingomyelin-and ceramide-cleaving enzymes in the small intestinal tract. Biochim. Biophys. Acta 176 (1969) 339-347
13. Duan R.D., Cheng Y., Hansen G., Hertervig E., Liu J.J., Syk I., et al. Purification, localization, and expression of human intestinal alkaline sphingomyelinase. J. Lipid Res. 44 (2003) 1241-1250
14. Duan R.D., Bergman T., Xu N., Wu J., Cheng Y., Duan J., et al. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J. Biol. Chem. 278 (2003) 38528-38536
15. Sjöqvist U., Hertervig E., Nilsson Å., Duan R.D., Ost A., Tribukait B., and Lofberg R. Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity. Inflamm. Bowel Dis. 8 (2002) 258-263
16. Hertervig E., Nilsson Å., Nyberg L., and Duan R.D. Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer 79 (1996) 448-453
17. Wu J., Cheng Y., Nilsson Å., and Duan R.D. Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells. Carcinogenesis 25 (2004) 1327-1333
18. Cheng Y., Tauschel H.T., Nilsson Å., and Duan R.D. Administration of ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in rat colon. Scand. J. Gastroenterol. 34 (1999) 915-920
19. Duan R.D., and Nilsson Å. Sphingolipid hydrolyzing enzymes in the gastrointestinal tract. Methods Enzymol. 311 (2000) 276-286
20. Liu J.J., Nilsson Å., Oredsson S., Badmaev V., Zhao W.Z., and Duan R.D. Boswellic acids trigger apoptosis via a pathway dependent on caspase 8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 23 (2002) 2087-2093
21. Peterson M.D., and Mooseker M.S. Characterization of the enterocyte-like brush border cytoskeleton of the C2BBe clones of the human intestinal cell line, Caco-2. J. Cell Sci. 102 (1992) 581-600
22. Stennicke H.R., and Salvesen G.S. Properties of the caspases. Biochim. Biophys. Acta 1387 (1998) 17-31
23. Cheng Y., Ohlsson L., and Duan R.D. Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice. Br. J. Nutr. 91 (2004) 715-723
24. Levade T., and Jaffrézou J.P. Signalling sphingomyelinase: which, where, how and why?. Biochim. Biophys. Acta 1438 (1999) 1-17
25. Andersson D., Liu J.J., Nilsson Å., and Duan R.D. Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase. Anticancer Res. 23 (2003) 3317-3322