메뉴 건너뛰기




Volumn 20, Issue 6, 2007, Pages 909-918

Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: Role of guanine nucleotide exchange factor Vav2

Author keywords

Hyperhomocysteinemia; Kinase; Redox signaling; Small G protein; Sphingolipids

Indexed keywords

CERAMIDE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HOMOCYSTEINE; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; SUPEROXIDE; VAV PROTEIN;

EID: 35848932330     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000110451     Document Type: Article
Times cited : (28)

References (43)
  • 1
    • 0030923631 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia and end stage renal disease
    • Gupta A, Robinson K: Hyperhomocysteinaemia and end stage renal disease. J Nephrol 1997;10:77-84.
    • (1997) J Nephrol , vol.10 , pp. 77-84
    • Gupta, A.1    Robinson, K.2
  • 2
    • 0030929483 scopus 로고    scopus 로고
    • Hyperhomocysteinemia: Detection, risk assessment, and treatment
    • Dennis VW, Nurko S, Robinson K: Hyperhomocysteinemia: Detection, risk assessment, and treatment. Curr Opin Nephrol Hypertens 1997;6:483-488.
    • (1997) Curr Opin Nephrol Hypertens , vol.6 , pp. 483-488
    • Dennis, V.W.1    Nurko, S.2    Robinson, K.3
  • 3
  • 4
    • 34250799639 scopus 로고    scopus 로고
    • Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats
    • Yi F, Dos Santos EA, Xia M, Chen QZ, Li PL, Li N: Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats. Am J Nephrol 2007;27:262-268.
    • (2007) Am J Nephrol , vol.27 , pp. 262-268
    • Yi, F.1    Dos Santos, E.A.2    Xia, M.3    Chen, Q.Z.4    Li, P.L.5    Li, N.6
  • 5
    • 0037336095 scopus 로고    scopus 로고
    • Homocysteine enhances timp-1 expression and cell proliferation associated with nadh oxidase in rat mesangial cells
    • Yang ZZ, Zou AP: Homocysteine enhances timp-1 expression and cell proliferation associated with nadh oxidase in rat mesangial cells. Kidney Int 2003;63:1012-1020.
    • (2003) Kidney Int , vol.63 , pp. 1012-1020
    • Yang, Z.Z.1    Zou, A.P.2
  • 6
    • 21644461236 scopus 로고    scopus 로고
    • Homocysteine activates nadh/nadph oxidase through ceramide-stimulated rac gtpase activity in rat mesangial cells
    • Yi F, Zhang AY, Janscha JL, Li PL, Zou AP: Homocysteine activates nadh/nadph oxidase through ceramide-stimulated rac gtpase activity in rat mesangial cells. Kidney Int 2004;66:1977-1987.
    • (2004) Kidney Int , vol.66 , pp. 1977-1987
    • Yi, F.1    Zhang, A.Y.2    Janscha, J.L.3    Li, P.L.4    Zou, A.P.5
  • 7
    • 33745711919 scopus 로고    scopus 로고
    • Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats
    • Yi F, Zhang AY, Li N, Muh RW, Fillet M, Renert AF, Li PL: Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats. Kidney Int 2006;70:88-96.
    • (2006) Kidney Int , vol.70 , pp. 88-96
    • Yi, F.1    Zhang, A.Y.2    Li, N.3    Muh, R.W.4    Fillet, M.5    Renert, A.F.6    Li, P.L.7
  • 8
    • 33846892487 scopus 로고    scopus 로고
    • Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase
    • Shastry S, Ingram AJ, Scholey JW, James LR: Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase. Kidney Int 2007;71:304-311.
    • (2007) Kidney Int , vol.71 , pp. 304-311
    • Shastry, S.1    Ingram, A.J.2    Scholey, J.W.3    James, L.R.4
  • 9
    • 33750897683 scopus 로고    scopus 로고
    • Regulation of novel superoxide-producing nad(p)h oxidases
    • Takeya R, Sumimoto H: Regulation of novel superoxide-producing nad(p)h oxidases. Antioxid Redox Signal 2006;8:1523-1532.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1523-1532
    • Takeya, R.1    Sumimoto, H.2
  • 10
    • 33846794822 scopus 로고    scopus 로고
    • The nox family of ros-generating nadph oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH: The nox family of ros-generating nadph oxidases: Physiology and pathophysiology. Physiol Rev 2007;87:245-313.
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 11
    • 18044377401 scopus 로고    scopus 로고
    • Nad(p)h oxidase-dependent selfpropagation of hydrogen peroxide and vascular disease
    • Cai H: Nad(p)h oxidase-dependent selfpropagation of hydrogen peroxide and vascular disease. Circ Res 2005;96:818-822.
    • (2005) Circ Res , vol.96 , pp. 818-822
    • Cai, H.1
  • 13
    • 0037108109 scopus 로고    scopus 로고
    • Current molecular models for nadph oxidase regulation by rac gtpase
    • Bokoch GM, Diebold BA: Current molecular models for nadph oxidase regulation by rac gtpase. Blood 2002;100:2692-2696.
    • (2002) Blood , vol.100 , pp. 2692-2696
    • Bokoch, G.M.1    Diebold, B.A.2
  • 14
    • 33645285957 scopus 로고    scopus 로고
    • Regulation of nadph oxidases: The role of rac proteins
    • Hordijk PL: Regulation of nadph oxidases: The role of rac proteins. Circ Res 2006;98:453-462.
    • (2006) Circ Res , vol.98 , pp. 453-462
    • Hordijk, P.L.1
  • 16
    • 0037069690 scopus 로고    scopus 로고
    • Rho gtpases in cell biology
    • Etienne-Manneville S, Hall A: Rho gtpases in cell biology. Nature 2002;420:629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 17
    • 33750924781 scopus 로고    scopus 로고
    • Regulation of the phagocyte nadph oxidase by rac gtpase
    • Bokoch GM, Zhao T: Regulation of the phagocyte nadph oxidase by rac gtpase. Antioxid Redox Signal 2006;8:1533-1548.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1533-1548
    • Bokoch, G.M.1    Zhao, T.2
  • 18
    • 0025944684 scopus 로고
    • Activation of the nadph oxidase involves the small gtp-binding protein p21rac1
    • Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW: Activation of the nadph oxidase involves the small gtp-binding protein p21rac1. Nature 1991;353:668-670.
    • (1991) Nature , vol.353 , pp. 668-670
    • Abo, A.1    Pick, E.2    Hall, A.3    Totty, N.4    Teahan, C.G.5    Segal, A.W.6
  • 19
    • 0035575585 scopus 로고    scopus 로고
    • Rho family proteins: Coordinating cell responses
    • Ridley AJ: Rho family proteins: Coordinating cell responses. Trends Cell Biol 2001;11:471-477.
    • (2001) Trends Cell Biol , vol.11 , pp. 471-477
    • Ridley, A.J.1
  • 20
    • 18844449626 scopus 로고    scopus 로고
    • Vav-family proteins in t-cell signalling
    • Tybulewicz VL: Vav-family proteins in t-cell signalling. Curr Opin Immunol 2005;17:267-274.
    • (2005) Curr Opin Immunol , vol.17 , pp. 267-274
    • Tybulewicz, V.L.1
  • 21
    • 0242384071 scopus 로고    scopus 로고
    • Vav proteins, masters of the world of cytoskeleton organization
    • Hornstein I, Alcover A, Katzav S: Vav proteins, masters of the world of cytoskeleton organization. Cell Signal 2004;16:1-11.
    • (2004) Cell Signal , vol.16 , pp. 1-11
    • Hornstein, I.1    Alcover, A.2    Katzav, S.3
  • 22
    • 35848942703 scopus 로고    scopus 로고
    • Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W: Vav proteins control myd88-dependent oxidative burst. Blood 2006.
    • Miletic AV, Graham DB, Montgrain V, Fujikawa K, Kloeppel T, Brim K, Weaver B, Schreiber R, Xavier R, Swat W: Vav proteins control myd88-dependent oxidative burst. Blood 2006.
  • 23
    • 33750310510 scopus 로고    scopus 로고
    • Vav proteins in neutrophils are required for fcgammar-mediated signaling to rac gtpases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)
    • Utomo A, Cullere X, Glogauer M, Swat W, Mayadas TN: Vav proteins in neutrophils are required for fcgammar-mediated signaling to rac gtpases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol 2006;177:6388-6397.
    • (2006) J Immunol , vol.177 , pp. 6388-6397
    • Utomo, A.1    Cullere, X.2    Glogauer, M.3    Swat, W.4    Mayadas, T.N.5
  • 24
    • 33845751023 scopus 로고    scopus 로고
    • The rac effector p67phox regulates phagocyte nadph oxidase by stimulating vav1 guanine nucleotide exchange activity
    • Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC: The rac effector p67phox regulates phagocyte nadph oxidase by stimulating vav1 guanine nucleotide exchange activity. Mol Cell Biol 2007;27:312-323.
    • (2007) Mol Cell Biol , vol.27 , pp. 312-323
    • Ming, W.1    Li, S.2    Billadeau, D.D.3    Quilliam, L.A.4    Dinauer, M.C.5
  • 25
    • 33846219576 scopus 로고    scopus 로고
    • Autocrine/paracrine pattern of superoxide production through nad(p)h oxidase in coronary arterial myocytes
    • Zhang G, Zhang F, Muh R, Yi F, Chalupsky K, Cai H, Li PL: Autocrine/paracrine pattern of superoxide production through nad(p)h oxidase in coronary arterial myocytes. Am J Physiol Heart Circ Physiol 2007;292:H483-495.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Zhang, G.1    Zhang, F.2    Muh, R.3    Yi, F.4    Chalupsky, K.5    Cai, H.6    Li, P.L.7
  • 26
    • 0034269240 scopus 로고    scopus 로고
    • Structural basis for relief of autoinhibition of the dbl homology domain of proto-oncogene vav by tyrosine phosphorylation
    • Aghazadeh B, Lowry WE, Huang XY, Rosen MK: Structural basis for relief of autoinhibition of the dbl homology domain of proto-oncogene vav by tyrosine phosphorylation. Cell 2000;102:625-633.
    • (2000) Cell , vol.102 , pp. 625-633
    • Aghazadeh, B.1    Lowry, W.E.2    Huang, X.Y.3    Rosen, M.K.4
  • 27
  • 28
    • 1642462459 scopus 로고    scopus 로고
    • Gtpases and reactive oxygen species: Switches for killing and signaling
    • Werner E: Gtpases and reactive oxygen species: Switches for killing and signaling. J Cell Sci 2004;117:143-153.
    • (2004) J Cell Sci , vol.117 , pp. 143-153
    • Werner, E.1
  • 29
    • 0026335622 scopus 로고
    • Regulation of phagocyte oxygen radical production by the gtp-binding protein rac 2
    • Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM: Regulation of phagocyte oxygen radical production by the gtp-binding protein rac 2. Science 1991;254:1512-1515.
    • (1991) Science , vol.254 , pp. 1512-1515
    • Knaus, U.G.1    Heyworth, P.G.2    Evans, T.3    Curnutte, J.T.4    Bokoch, G.M.5
  • 30
    • 0031787341 scopus 로고    scopus 로고
    • Guinea pig gastric mucosal cells produce abundant superoxide anion through an nadph oxidase-like system
    • Teshima S, Rokutan K, Nikawa T, Kishi K: Guinea pig gastric mucosal cells produce abundant superoxide anion through an nadph oxidase-like system. Gastroenterology 1998;115:1186-1196.
    • (1998) Gastroenterology , vol.115 , pp. 1186-1196
    • Teshima, S.1    Rokutan, K.2    Nikawa, T.3    Kishi, K.4
  • 33
    • 33745815084 scopus 로고    scopus 로고
    • Nox1-dependent reactive oxygen generation is regulated by rac1
    • Cheng G, Diebold BA, Hughes Y, Lambeth JD: Nox1-dependent reactive oxygen generation is regulated by rac1. J Biol Chem 2006;281:17718-17726.
    • (2006) J Biol Chem , vol.281 , pp. 17718-17726
    • Cheng, G.1    Diebold, B.A.2    Hughes, Y.3    Lambeth, J.D.4
  • 34
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a rac gtpase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y: Rational design and characterization of a rac gtpase-specific small molecule inhibitor. Proc Natl Acad Sci U S A 2004;101:7618-7623.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 35
    • 13444252631 scopus 로고    scopus 로고
    • Gef means go: Turning on rho gtpases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ, Sondek J: Gef means go: Turning on rho gtpases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 2005;6:167-180.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 36
    • 0037166293 scopus 로고    scopus 로고
    • Rac activation induces nadph oxidase activity in transgenic cosphox cells, and the level of superoxide production is exchange factor-dependent
    • Price MO, Atkinson SJ, Knaus UG, Dinauer MC: Rac activation induces nadph oxidase activity in transgenic cosphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem 2002;277:19220-19228.
    • (2002) J Biol Chem , vol.277 , pp. 19220-19228
    • Price, M.O.1    Atkinson, S.J.2    Knaus, U.G.3    Dinauer, M.C.4
  • 37
    • 0024433697 scopus 로고
    • Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
    • Katzav S, Martin-Zanca D, Barbacid M: Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. Embo J 1989;8:2283-2290.
    • (1989) Embo J , vol.8 , pp. 2283-2290
    • Katzav, S.1    Martin-Zanca, D.2    Barbacid, M.3
  • 38
    • 0033974061 scopus 로고    scopus 로고
    • Regulatory and signaling properties of the vav family
    • Bustelo XR: Regulatory and signaling properties of the vav family. Mol Cell Biol 2000;20:1461-1477.
    • (2000) Mol Cell Biol , vol.20 , pp. 1461-1477
    • Bustelo, X.R.1
  • 39
    • 0035660246 scopus 로고    scopus 로고
    • Sphingolipids in mammalian cell signalling
    • Ohanian J, Ohanian V: Sphingolipids in mammalian cell signalling. Cell Mol Life Sci 2001;58:2053-2068.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 2053-2068
    • Ohanian, J.1    Ohanian, V.2
  • 40
    • 0031754498 scopus 로고    scopus 로고
    • Src kinase and pi 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle
    • Ibitayo AI, Tsunoda Y, Nozu F, Owyang C, Bitar KN: Src kinase and pi 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle. Am J Physiol 1998;275:G705-711.
    • (1998) Am J Physiol , vol.275
    • Ibitayo, A.I.1    Tsunoda, Y.2    Nozu, F.3    Owyang, C.4    Bitar, K.N.5
  • 41
    • 30044444270 scopus 로고    scopus 로고
    • Activation of rac by cadherin through the c-src-rap1-phosphatidylinositol 3-kinase-vav2 pathway
    • Fukuyama T, Ogita H, Kawakatsu T, Inagaki M, Takai Y: Activation of rac by cadherin through the c-src-rap1-phosphatidylinositol 3-kinase-vav2 pathway. Oncogene 2006;25:8-19.
    • (2006) Oncogene , vol.25 , pp. 8-19
    • Fukuyama, T.1    Ogita, H.2    Kawakatsu, T.3    Inagaki, M.4    Takai, Y.5
  • 43
    • 0141668894 scopus 로고    scopus 로고
    • Rac1 function is required for src-induced transformation. Evidence of a role for tiam1 and vav2 in rac activation by src
    • Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind JS: Rac1 function is required for src-induced transformation. Evidence of a role for tiam1 and vav2 in rac activation by src. J Biol Chem 2003;278:34339-34346.
    • (2003) J Biol Chem , vol.278 , pp. 34339-34346
    • Servitja, J.M.1    Marinissen, M.J.2    Sodhi, A.3    Bustelo, X.R.4    Gutkind, J.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.