Synthesis and biological evaluation of 6-substituted purinylcarbanucleosides with a cyclopenta[b]thiophene pseudosugar

Synthesis

Volumn , Issue 16, 2009, Pages 2766-2772

  Abeijón, Paula ^a   Blanco, José M ^a   Caamaño, Olga ^a   Fernández, Franco ^a   García, Marcos D ^b   García Mera, Xerardo ^a   Rodríguez Borges, José E ^c   Balzarini, Jan ^d   De Clercq, Erik ^d  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c CIQ (Investigation Centre)   (Portugal)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Biological activity; Cyclopenta b thiophene; Heterobicyclic amino alcohol; Purinylcarbanucleoside; Suzuki Miyaura cross coupling reaction

Indexed keywords

BIOLOGICAL ACTIVITY; CYCLOPENTA[B]THIOPHENE; HETEROBICYCLIC AMINO ALCOHOL; PURINYLCARBANUCLEOSIDE; SUZUKI-MIYAURA CROSS-COUPLING REACTION;

AMINATION; BIOACTIVITY; METHANOL; ORGANIC POLYMERS; SYNTHESIS (CHEMICAL); THIOPHENE;

AMINES;

4 (6 AMINO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; 4 (6 CHLORO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; 4 (6 CYCLOPROPYLAMINO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; 4 (6 PHENYL 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; 6,9 DIHYDRO 9 [(6 HYDROXYMETHYL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 4 YL] 1H PURIN 6 ONE; 6,9 DIHYDRO 9 [TRANS (6 HYDROXYMETHYL 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 4 YL)] 1H PURIN 6 ONE; [4 (6 AMINO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; [4 (6 CHLORO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; [4 (6 CYCLOPROPYLAMINO 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; [4 (6 PHENYL 9H PURIN 9 YL) 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHEN 6 YL]METHANOL; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CYTOSTASIS; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; NONHUMAN; SUZUKI REACTION; T LYMPHOBLAST;

EID: 70449347943     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0029-1216908     Document Type: Article

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