Carbocyclic analogues of nucleosides from bis-(hydroxymethyl)-cyclopentane: Synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues

Chemical and Pharmaceutical Bulletin

Volumn 51, Issue 9, 2003, Pages 1060-1063

  Blanco, José Manuel ^a   Caamaño, Olga ^a   Fernández, Franco ^a   Rodríguez Borges, José Enrique ^b   Balzarini, Jan ^c   De Clercq, Erik ^c  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b CIQ (Investigation Centre)   (Portugal)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Adenosine analogue; Antiviral activity; Carbocyclic nucleoside; Cytostatic activity; Uridine analogue

Indexed keywords

(1BETA,2ALPHA,4BETA) 4 (6 AMINO 9H PURIN 9 YL) 1,2 CYCLOPENTANEDIMETHANOL; (1BETA,2ALPHA,4BETA) 4 (6 CYCLOPROPYLAMINO 9H PURIN 9 YL) 1,2 CYCLOPENTANEDIMETHANOL; 1 [(1BETA,2ALPHA,4BETA) 2,4 BIS(HYDROXYMETHYL)CYCLOPENTYL] 1,2,3,4 TETRAHYDROPYRIMIDINE 2,4 DIONE; 1 [(1BETA,2ALPHA,4BETA) 2,4 BIS(HYDROXYMETHYL)CYCLOPENTYL] 5 IODO 1,2,3,4 TETRAHYDROPYRIMIDINE 2,4 DIONE; 1 [(1BETA,3ALPHA,4BETA) 3,4 BIS(HYDROXYMETHYL)CYCLOPENTYL] 5 IODO 1,2,3,4 TETRAHYDROPYRIMIDINE 2,4 DIONE; 6,9 DIHYDRO 9 [(1BETA,3ALPHA,4BETA) 3,4 BIS(HYDROXYMETHYL)CYCLOPENTYL] 1H PURIN 6 ONE; ADENOSINE DERIVATIVE; CARBOCYCLIC NUCLEOSIDE; CYCLOPENTANE DERIVATIVE; INOSINE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; ADENOSINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BIS (HYDROXYMETHYL) CYCLOPENTANE; BIS-(HYDROXYMETHYL)-CYCLOPENTANE; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; INOSINE; URIDINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOSTASIS; DRUG SYNTHESIS; EMBRYO; FEMALE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; MOUSE; NONHUMAN; PARAINFLUENZA VIRUS; REOVIRUS; TUMOR CELL; VARICELLA ZOSTER VIRUS; VESICULAR STOMATITIS VIRUS; ANIMAL; CHEMISTRY; DNA VIRUS; DRUG EFFECT; DRUG SCREENING; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA VIRUS; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; TUMOR CELL LINE;

ADENOSINE; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; CYCLOPENTANES; DNA VIRUSES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDICATORS AND REAGENTS; INOSINE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; RNA VIRUSES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; URIDINE;

EID: 2142824137     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.51.1060     Document Type: Article

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