A convenient synthesis of new purinyl-homo-carbonucleosides on a cyclopentane ring fused with pyridazine

Synthesis

Volumn , Issue 17, 2004, Pages 2855-2862

  Caamaño, Olga ^a   Gómez, Generosa ^b   Fernández, Franco ^a   García, Marcos Daniel ^a   García Mera, Xerardo ^a   De Clercq, Eric ^c  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF VIGO   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acylation; Carbocyclic nucleosides; Diols; Heterocycles; Ozonolysis; Pyridazine

Indexed keywords

OZONE LAYER; REDUCTION; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

MESYLATION; MONOPROTECTION; PURINE POSITION; REDUCTIVE CLEAVAGE;

ETHERS;

1,4 DIPHENYL 5,8 DIHYDRO 5,8 METHANOPHTHALAZINE; 5 [(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 7 [(6 CHLORO 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZINE; 6 CHLOROPURINE; 9 [[7 (HYDROXYMETHYL) 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHYL] 1,9 DIHYDROPURIN 6 ONE; 9 [[7 [(TERT BUTYLDIMETHYLSILYLOXY)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHYL] N CYCLOPENTYL 9H PURIN 6 AMINE; [7 [(6 CHLORO 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHANOL; [7 [(6 CYCLOPENTYLAMINO 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHANOL; [7 [(6 CYCLOPROPYLAMINE 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHYL ACETATE; [7 [(6 CYCLOPROPYLAMINO 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHANOL; [7 [(6 METHOXY 9H PURIN 9 YL)METHYL] 1,4 DIPHENYL 6,7 DIHYDRO 5H CYCLOPENTA[D]PYRIDAZIN 5 YL]METHANOL; CARBOCYCLIC NUCLEOSIDE; CHLORINE; CYCLOPENTANE; HETEROCYCLIC COMPOUND; PHTHALAZINE DERIVATIVE; PURINE; PURINYL HOMO CARBONUCLEOSIDE; PYRIDAZINE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; OZONOLYSIS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 10644239990     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-834870     Document Type: Article

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