Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4 + CEM cells: Comparison with (-)-carbovir

Biochemical Pharmacology

Volumn 68, Issue 9, 2004, Pages 1797-1805

  Mahony, William B ^a,b   Domin, Barbara A ^a,b   Daluge, Susan M ^a   Zimmerman, Thomas P ^b  

^a GLAXOSMITHKLINE   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

Abacavir; Drug transport; Erythrocyte ghosts; HIV; Influx kinetics; Nonfacilitated diffusion

Indexed keywords

ABACAVIR; CARBOVIR;

ARTICLE; BIOAVAILABILITY; CELL ASSAY; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG INHIBITION; DRUG PENETRATION; DRUG TRANSPORT; ERYTHROCYTE; ERYTHROCYTE GHOST; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MEMBRANE PERMEABILITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; QUALITATIVE ANALYSIS; T LYMPHOBLAST; T LYMPHOCYTE SUBPOPULATION; TEMPERATURE DEPENDENCE;

ANTI-HIV AGENTS; BIOLOGICAL TRANSPORT; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE PERMEABILITY; DIDEOXYNUCLEOSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HUMANS; KINETICS;

EID: 4644372567     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.06.025     Document Type: Article

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