Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity

Virology

Volumn 394, Issue 2, 2009, Pages 200-207

  Horiuchi, Motohiro ^a   Karino, Ayako ^b   Furuoka, Hidefumi ^b   Ishiguro, Naotaka ^c   Kimura, Kumiko ^d   Shinagawa, Morikazu ^d  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Infectivity; Monoclonal antibody; Peptide phage display; Prion; Transmissible spongiform encephalopathy

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6H10; PRION PROTEIN; PROTEINASE K; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ARTICLE; BRAIN HOMOGENATE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRION; PRIORITY JOURNAL; PROTEIN PURIFICATION; STRUCTURE ANALYSIS; VIRULENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BASE SEQUENCE; BRAIN; BRAIN CHEMISTRY; CATTLE; DNA PRIMERS; EPITOPES; FEMALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PRPC PROTEINS; PRPSC PROTEINS; SHEEP;

BOS; MUS; OVIS ARIES;

EID: 70449107071     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.08.025     Document Type: Article

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