Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation

Journal of Neurochemistry

Volumn 89, Issue 2, 2004, Pages 454-463

  Perrier, Véronique ^a   Solassol, Jérôme ^a   Crozet, Carole ^a   Frobert, Yveline ^b   Mourton Gilles, Chantal ^c   Grassi, Jacques ^b   Lehmann, Sylvain ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

^b CEA SACLAY   (France)

^c CNRS   (France)

Author keywords

Anti prion agent; Antibodies mechanism and therapeutic; Prion disease

Indexed keywords

AMINO ACID DERIVATIVE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 11C6; MONOCLONAL ANTIBODY 3B5; MONOCLONAL ANTIBODY SAF34; MONOCLONAL ANTIBODY SAF37; MONOCLONAL ANTIBODY SAF60; MONOCLONAL ANTIBODY SAF61; MONOCLONAL ANTIBODY SAF70; PRION ANTIBODY; PRION PROTEIN; PROTEIN; PROTEIN HUPRP; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HALF LIFE TIME; MOUSE; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; HUMANS; MICE; NEUROBLASTOMA; PRION DISEASES; PRPC PROTEINS; PRPSC PROTEINS;

ANIMALIA;

EID: 1942519718     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02356.x     Document Type: Article

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