Microwave-assisted Ullmann C-S bond formation: Synthesis of the P38α MAPK clinical candidate VX-745

Journal of Organic Chemistry

Volumn 74, Issue 21, 2009, Pages 8336-8342

  Bagley, Mark C ^a   Davis, Terence ^a   Dix, Matthew C ^a   Fusillo, Vincenzo ^a   Pigeaux, Morgane ^a   Rokicki, Michal J ^a   Kipling, David ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AS-LIGANDS; BASIC CONDITIONS; BOND FORMATION; CHEMICAL EQUATIONS; COPPER IODIDE; DERMAL FIBROBLASTS; FOUR-STEP SYNTHESIS; HIGH YIELD; IMMUNOBLOTS; INHIBITORY ACTIVITY; MICROWAVE-ASSISTED; PALLADIUM CATALYST; THIOPHENOLS; TRANS-CYCLOHEXANE; WERNER SYNDROME;

CATALYSTS; CELL CULTURE; CHEMICAL BONDS; CHEMICAL REACTIONS; IRRADIATION; LIGANDS; PALLADIUM;

MICROWAVE IRRADIATION;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; CARBON; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE 14; SULFUR;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MICROWAVE IRRADIATION; SKIN FIBROBLAST; WERNER SYNDROME;

MAGNETIC RESONANCE SPECTROSCOPY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDAZINES; PYRIMIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 70350724454     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9017155     Document Type: Article

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