An improved synthesis of 5-(2,6-dichlorophenyl)-2-(phenylthio)-6H- pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

Molecules

Volumn 6, Issue 12, 2001, Pages 959-963

  Treu, Matthias ^a   Jordis, Ulrich ^a   Lee, Ving J ^b  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^b Entelos Inc   (United States)

Author keywords

DMF acetal heterocyclization; Nucleophilic substitution

Indexed keywords

5 (2,6 DICHLOROPHENYL) 2 (PHENYLTHIO) 6H PYRIMIDO[1,6 B]PYRADAZIN 6 ONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; VX 745;

CONFERENCE PAPER; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 3342903327     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/61200959     Document Type: Conference Paper

References (4)

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2. (b) Ferraccioli, G. F. VX-745 Vertex Pharmaceuticals. Curr. Opin. Anti-Inflammatory Immunomodulatory Invest. Drugs 2000, 2, 74-77.
3. Bemis, G. W.; Salituro, F. G.; Duffy, J. P.; Cochran, J. E.; Harrington, E. M.; Murcko, M. A.; Wilson, K. P.; Galullo, V. P. Preparation of annelated pyrimidinones and analogs as p38 kinase inhibitors. WO 98/27098, 25 Jun 1998 [Chem. Abstr. 1998, 129, 81749].
4. Bemis, G. W.; Salituro, F. G.; Duffy, J. P.; Harrington, E. M. Preparation of pyrido[1,2-c]-pyrimidin-3-ones or 1,2-dihydro-pyrido[1,2-c] pyrimidin-3-ones as inhibitors of p38. US 6147080, 14 Nov 2000 [Chem. Abstr. 2000, 133, 350242].