메뉴 건너뛰기




Volumn 27, Issue 3, 2009, Pages 123-129

Telomeres and telomerase in chronic myeloid leukaemia: Impact for pathogenesis, disease progression and targeted therapy

Author keywords

Bcr Abl; Blast crisis; Chronic myeloid leukaemia; Telomerase; Telomere

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; BCR ABL PROTEIN; BIBR 1532; BLEOMYCIN; DOXORUBICIN; ETOPOSIDE; GRN 163L; HYDROXYUREA; IMATINIB; MESSENGER RNA; SMALL INTERFERING RNA; TANKYRASE; TELOMERASE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

EID: 70350708508     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.901     Document Type: Review
Times cited : (41)

References (67)
  • 1
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97(4): 503-514.
    • (1999) Cell , vol.97 , Issue.4 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfield, S.3
  • 2
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. Telomere states and cell fates. Nature 2000; 408(6808): 53-56.
    • (2000) Nature , vol.408 , Issue.6808 , pp. 53-56
    • Blackburn, E.H.1
  • 3
    • 0037192927 scopus 로고    scopus 로고
    • Tiptoeing to chromosome tips: Facts, promises and perils of today's human telomere biology
    • Fajkus J, Simickova M, Malaska J. Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology. Philos Trans R Soc Lond B Biol Sci 2002; 357(1420): 545-562.
    • (2002) Philos Trans R Soc Lond B Biol Sci , vol.357 , Issue.1420 , pp. 545-562
    • Fajkus, J.1    Simickova, M.2    Malaska, J.3
  • 4
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005; 19(18): 2100-2110.
    • (2005) Genes Dev , vol.19 , Issue.18 , pp. 2100-2110
    • De Lange, T.1
  • 5
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345(6274): 458-460.
    • (1990) Nature , vol.345 , Issue.6274 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 7
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: The senescence connection
    • Deng Y, Chan SS, Chang S. Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer 2008; 8(6): 450-458.
    • (2008) Nat Rev Cancer , vol.8 , Issue.6 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 8
    • 0036362266 scopus 로고    scopus 로고
    • Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again
    • Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again. Differentiation 2002; 69(4-5): 188-197.
    • (2002) Differentiation , vol.69 , Issue.4-5 , pp. 188-197
    • Forsyth, N.R.1    Wright, W.E.2    Shay, J.W.3
  • 9
    • 0034020630 scopus 로고    scopus 로고
    • Mammalian telomeres and telomerase
    • Collins K. Mammalian telomeres and telomerase. Curr Opin Cell Biol 2000; 12(3): 378-383.
    • (2000) Curr Opin Cell Biol , vol.12 , Issue.3 , pp. 378-383
    • Collins, K.1
  • 10
    • 0033600731 scopus 로고    scopus 로고
    • Human is a unique species among primates in terms of telomere length
    • Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Commun 1999; 263(2): 308-314.
    • (1999) Biochem Biophys Res Commun , vol.263 , Issue.2 , pp. 308-314
    • Kakuo, S.1    Asaoka, K.2    Ide, T.3
  • 11
    • 0035865618 scopus 로고    scopus 로고
    • Telomere length in leukocyte subpopulations of patients with aplastic anemia
    • Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 2001; 97(4): 895-900.
    • (2001) Blood , vol.97 , Issue.4 , pp. 895-900
    • Brummendorf, T.H.1    Maciejewski, J.P.2    Mak, J.3    Young, N.S.4    Lansdorp, P.M.5
  • 12
    • 0343750701 scopus 로고    scopus 로고
    • Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry
    • Brummendorf TH, Holyoake TL, Rufer N, et al. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 2000; 95(6): 1883-1890.
    • (2000) Blood , vol.95 , Issue.6 , pp. 1883-1890
    • Brummendorf, T.H.1    Holyoake, T.L.2    Rufer, N.3
  • 13
    • 0031451827 scopus 로고    scopus 로고
    • Telomere length in myelodysplastic syndromes
    • Boultwood J, Fidler C, Kusec R, et al. Telomere length in myelodysplastic syndromes. Am J Hematol 1997; 56(4): 266-271.
    • (1997) Am J Hematol , vol.56 , Issue.4 , pp. 266-271
    • Boultwood, J.1    Fidler, C.2    Kusec, R.3
  • 14
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91(1): 25-34.
    • (1997) Cell , vol.91 , Issue.1 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3
  • 16
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995; 269(5228): 1236-1241.
    • (1995) Science , vol.269 , Issue.5228 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 17
    • 0030819894 scopus 로고    scopus 로고
    • Telomerase catalytic subunit homologs from fission yeast and human
    • Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277(5328): 955-959.
    • (1997) Science , vol.277 , Issue.5328 , pp. 955-959
    • Nakamura, T.M.1    Morin, G.B.2    Chapman, K.B.3
  • 18
    • 0030910465 scopus 로고    scopus 로고
    • Formation of de novo centromeres and construction of firstgeneration human artificial microchromosomes
    • Harrington JJ, Van Bokkelen G, Mays RW, Gustashaw K, Willard HF. Formation of de novo centromeres and construction of firstgeneration human artificial microchromosomes. Nat Genet 1997; 15(4): 345-355.
    • (1997) Nat Genet , vol.15 , Issue.4 , pp. 345-355
    • Harrington, J.J.1    Van Bokkelen, G.2    Mays, R.W.3    Gustashaw, K.4    Willard, H.F.5
  • 19
    • 0037148401 scopus 로고    scopus 로고
    • Regulation of the human telomerase reverse transcriptase gene
    • Ducrest AL, Szutorisz H, Lingner J, Nabholz M. Regulation of the human telomerase reverse transcriptase gene. Oncogene 2002; 21(4): 541-552.
    • (2002) Oncogene , vol.21 , Issue.4 , pp. 541-552
    • Ducrest, A.L.1    Szutorisz, H.2    Lingner, J.3    Nabholz, M.4
  • 20
    • 34247188473 scopus 로고    scopus 로고
    • Telomere and telomerase in stem cells
    • Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer 2007; 96(7): 1020-1024.
    • (2007) Br J Cancer , vol.96 , Issue.7 , pp. 1020-1024
    • Hiyama, E.1    Hiyama, K.2
  • 21
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33(5): 787-791.
    • (1997) Eur J Cancer , vol.33 , Issue.5 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 22
    • 0032143590 scopus 로고    scopus 로고
    • Regulation of telomere length and telomerase in T and B cells: A mechanism for maintaining replicative potential
    • Weng NP, Hathcock KS, Hodes RJ. Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential. Immunity 1998; 9(2): 151-157.
    • (1998) Immunity , vol.9 , Issue.2 , pp. 151-157
    • Weng, N.P.1    Hathcock, K.S.2    Hodes, R.J.3
  • 23
    • 33746425690 scopus 로고    scopus 로고
    • Telomere-related genome instability in cancer
    • De Lange T. Telomere-related genome instability in cancer. Cold Spring Harb Symp Quant Biol 2005; 70: 197-204.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 197-204
    • De Lange, T.1
  • 24
    • 0038100233 scopus 로고    scopus 로고
    • Molecular mechanisms of transformation by the BCR-ABL oncogene
    • Sattler M, Griffin JD. Molecular mechanisms of transformation by the BCR-ABL oncogene. Semin Hematol 2003; 40 (suppl. 2):4-10.
    • (2003) Semin Hematol , vol.40 , Issue.SUPPL. 2 , pp. 4-10
    • Sattler, M.1    Griffin, J.D.2
  • 26
    • 3242883111 scopus 로고    scopus 로고
    • Telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia
    • Drummond M, Lennard A, Brummendorf T, Holyoake T. Telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia. Leuk Lymphoma 2004; 45(9): 1775-1781.
    • (2004) Leuk Lymphoma , vol.45 , Issue.9 , pp. 1775-1781
    • Drummond, M.1    Lennard, A.2    Brummendorf, T.3    Holyoake, T.4
  • 27
    • 0032891408 scopus 로고    scopus 로고
    • Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia
    • Boultwood J, Fidler C, Shepherd P, et al. Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia. Am J Hematol 1999; 61(1): 5-9.
    • (1999) Am J Hematol , vol.61 , Issue.1 , pp. 5-9
    • Boultwood, J.1    Fidler, C.2    Shepherd, P.3
  • 28
    • 0031050032 scopus 로고    scopus 로고
    • Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression
    • Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Shay JW, Toyama K. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia 1997; 11(2): 190-194.
    • (1997) Leukemia , vol.11 , Issue.2 , pp. 190-194
    • Ohyashiki, K.1    Ohyashiki, J.H.2    Iwama, H.3    Hayashi, S.4    Shay, J.W.5    Toyama, K.6
  • 29
    • 0035141317 scopus 로고    scopus 로고
    • Telomere dynamics and genetic instability in disease progression of chronic myeloid leukemia
    • Ohyashiki K, Iwama H, Tauchi T, et al. Telomere dynamics and genetic instability in disease progression of chronic myeloid leukemia. Leuk Lymphoma 2000; 40(1-2): 49-56.
    • (2000) Leuk Lymphoma , vol.40 , Issue.1-2 , pp. 49-56
    • Ohyashiki, K.1    Iwama, H.2    Tauchi, T.3
  • 30
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995; 92(20): 9082-9086.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.20 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    De Lange, T.3
  • 31
    • 0037148334 scopus 로고    scopus 로고
    • Telomeres and, telomerase in hematologic neoplasia
    • Ohyashiki JH, Sashida G, Tauchi T, Ohyashiki K, Telomeres and, telomerase in hematologic neoplasia. Oncogene 2002; 21(4): 680-687.
    • (2002) Oncogene , vol.21 , Issue.4 , pp. 680-687
    • Ohyashiki, J.H.1    Sashida, G.2    Tauchi, T.3    Ohyashiki, K.4
  • 32
    • 0033973802 scopus 로고    scopus 로고
    • Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture
    • Engelhardt M, Mackenzie K, Drullinsky P, Silver RT, Moore MA. Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture. Cancer Res 2000; 60(3): 610-617.
    • (2000) Cancer Res , vol.60 , Issue.3 , pp. 610-617
    • Engelhardt, M.1    Mackenzie, K.2    Drullinsky, P.3    Silver, R.T.4    Moore, M.A.5
  • 33
    • 38049057905 scopus 로고    scopus 로고
    • DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?
    • Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res 2007; 35(22): 7505-7513.
    • (2007) Nucleic Acids Res , vol.35 , Issue.22 , pp. 7505-7513
    • Passos, J.F.1    Saretzki, G.2    Von Zglinicki, T.3
  • 34
    • 0036629255 scopus 로고    scopus 로고
    • Oxidative stress shortens telomeres
    • von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27(7): 339-344.
    • (2002) Trends Biochem Sci , vol.27 , Issue.7 , pp. 339-344
    • Von Zglinicki, T.1
  • 35
    • 15044359303 scopus 로고    scopus 로고
    • Dysregulated expression of the major telomerase components in leukaemic stem cells
    • Drummond MW, Hoare SF, Monaghan A, et al. Dysregulated expression of the major telomerase components in leukaemic stem cells. Leukemia 2005; 19(3): 381-389.
    • (2005) Leukemia , vol.19 , Issue.3 , pp. 381-389
    • Drummond, M.W.1    Hoare, S.F.2    Monaghan, A.3
  • 36
    • 0030920228 scopus 로고    scopus 로고
    • Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells
    • Engelhardt M, Kumar R, Albanell J, Pettengell R, Han W, Moore MA. Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells. Blood 1997; 90(1): 182-193.
    • (1997) Blood , vol.90 , Issue.1 , pp. 182-193
    • Engelhardt, M.1    Kumar, R.2    Albanell, J.3    Pettengell, R.4    Han, W.5    Moore, M.A.6
  • 37
    • 0030886553 scopus 로고    scopus 로고
    • Lack of cell cycle regulation of telomerase activity in human cells
    • Holt SE, Aisner DL, Shay JW, Wright WE. Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci USA 1997; 94(20): 10687-10692.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.20 , pp. 10687-10692
    • Holt, S.E.1    Aisner, D.L.2    Shay, J.W.3    Wright, W.E.4
  • 38
    • 0031456031 scopus 로고    scopus 로고
    • Telomerase activity: A biomarker of cell proliferation, not malignant transformation
    • Belair CD, Yeager TR, Lopez PM, Reznikoff CA. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci USA 1997; 94(25): 13677-13682.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.25 , pp. 13677-13682
    • Belair, C.D.1    Yeager, T.R.2    Lopez, P.M.3    Reznikoff, C.A.4
  • 39
    • 0030900214 scopus 로고    scopus 로고
    • The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia
    • Iwama H, Ohyashiki K, Ohyashiki JH, et al. The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia. Cancer 1997; 79(8): 1552-1560.
    • (1997) Cancer , vol.79 , Issue.8 , pp. 1552-1560
    • Iwama, H.1    Ohyashiki, K.2    Ohyashiki, J.H.3
  • 40
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105(7): 2640-2653.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 41
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia. N Engl J Med 2003; 348(11): 994-1004.
    • (2003) N Engl J Med , vol.348 , Issue.11 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 42
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349(15): 1423-1432.
    • (2003) N Engl J Med , vol.349 , Issue.15 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 43
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYNkinaseoverexpression inchronicmyelogenousleukemiacells selected for resistance to STI571
    • Donato NJ, Wu JY, Stapley J, et al. BCR-ABL independence and LYNkinaseoverexpression inchronicmyelogenousleukemiacells selected for resistance to STI571. Blood 2003; 101(2): 690-698.
    • (2003) Blood , vol.101 , Issue.2 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3
  • 44
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002; 99(10): 3530-3539.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 45
    • 0037222727 scopus 로고    scopus 로고
    • Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia
    • Brummendorf TH, Ersoz I, Hartmann U, et al. Telomere length in peripheral blood granulocytes reflects response to treatment with imatinib in patients with chronic myeloid leukemia. Blood 2003; 101(1): 375-376.
    • (2003) Blood , vol.101 , Issue.1 , pp. 375-376
    • Brummendorf, T.H.1    Ersoz, I.2    Hartmann, U.3
  • 46
    • 20944447014 scopus 로고    scopus 로고
    • Telomere length and telomerase activity in the BCR-ABL-transformed murine Pro-B cell line BaF3 is unaffected by treatment with imatinib
    • Hartmann U, Balabanov S, Ziegler P, et al. Telomere length and telomerase activity in the BCR-ABL-transformed murine Pro-B cell line BaF3 is unaffected by treatment with imatinib. Exp Hematol 2005; 33(5): 542-549.
    • (2005) Exp Hematol , vol.33 , Issue.5 , pp. 542-549
    • Hartmann, U.1    Balabanov, S.2    Ziegler, P.3
  • 47
    • 70350755400 scopus 로고    scopus 로고
    • Abstract #3183
    • Bodoni et al. ASH 2008 Abstract #3183.
    • ASH 2008
    • Bodoni1
  • 48
    • 33646485121 scopus 로고    scopus 로고
    • HTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia
    • Campbell LJ, Fidler C, Eagleton H, et al. hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia. Leukemia 2006; 20(4): 671-679.
    • (2006) Leukemia , vol.20 , Issue.4 , pp. 671-679
    • Campbell, L.J.1    Fidler, C.2    Eagleton, H.3
  • 49
    • 0034193635 scopus 로고    scopus 로고
    • Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase
    • Kharbanda S, Kumar V, Dhar S, et al. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr Biol 2000; 10(10): 568-575.
    • (2000) Curr Biol , vol.10 , Issue.10 , pp. 568-575
    • Kharbanda, S.1    Kumar, V.2    Dhar, S.3
  • 50
    • 0242266597 scopus 로고    scopus 로고
    • Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia
    • Bakalova R, Ohba H, Zhelev Z, Ishikawa M, Shinohara Y, Baba Y. Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia. Biochem Pharmacol 2003; 66; (10): 1879-1884.
    • (2003) Biochem Pharmacol , vol.66 , Issue.10 , pp. 1879-1884
    • Bakalova, R.1    Ohba, H.2    Zhelev, Z.3    Ishikawa, M.4    Shinohara, Y.5    Baba, Y.6
  • 51
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008; 8(3): 167-179.
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 167-179
    • Harley, C.B.1
  • 52
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999; 5(10): 1164-1170.
    • (1999) Nat Med , vol.5 , Issue.10 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 53
    • 33748316825 scopus 로고    scopus 로고
    • Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells
    • Cerone MA, Londono-Vallejo JA, Autexier C. Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells. Mol Cancer Ther 2006; 5(7): 1669-1675.
    • (2006) Mol Cancer Ther , vol.5 , Issue.7 , pp. 1669-1675
    • Cerone, M.A.1    Londono-Vallejo, J.A.2    Autexier, C.3
  • 54
    • 17944401846 scopus 로고    scopus 로고
    • Telomerase is limiting the growth of acute myeloid leukemia cells
    • Roth A, Vercauteren S, Sutherland HJ, Lansdorp PM. Telomerase is limiting the growth of acute myeloid leukemia cells. Leukemia 2003; 17(12): 2410-2417.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2410-2417
    • Roth, A.1    Vercauteren, S.2    Sutherland, H.J.3    Lansdorp, P.M.4
  • 55
    • 23944516595 scopus 로고    scopus 로고
    • Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment
    • Ward RJ, Autexier C. Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol 2005; 68(3): 779-786.
    • (2005) Mol Pharmacol , vol.68 , Issue.3 , pp. 779-786
    • Ward, R.J.1    Autexier, C.2
  • 56
    • 4243937106 scopus 로고    scopus 로고
    • A highly selective telomerase inhibitor limiting human cancer cell proliferation
    • Damm K, Hemmann U, Garin-Chesa P, et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. Embo J 2001; 20(24): 6958-6968.
    • (2001) Embo J , vol.20 , Issue.24 , pp. 6958-6968
    • Damm, K.1    Hemmann, U.2    Garin-Chesa, P.3
  • 57
    • 46349092643 scopus 로고    scopus 로고
    • Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines
    • Parsch D, Brassat U, Brummendorf TH, Fellenberg J. Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. Cancer Invest 2008; 26(6): 590-596.
    • (2008) Cancer Invest , vol.26 , Issue.6 , pp. 590-596
    • Parsch, D.1    Brassat, U.2    Brummendorf, T.H.3    Fellenberg, J.4
  • 59
    • 23444453219 scopus 로고    scopus 로고
    • Lipid modification of GRN163, an N3'->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    • Herbert BS, Gellert GC, Hochreiter A, et al. Lipid modification of GRN163, an N3'->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene 2005; 24(33): 5262-5268.
    • (2005) Oncogene , vol.24 , Issue.33 , pp. 5262-5268
    • Herbert, B.S.1    Gellert, G.C.2    Hochreiter, A.3
  • 61
    • 33748537714 scopus 로고    scopus 로고
    • Telomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cells
    • de Souza Nascimento P, Alves G, Fiedler W. Telomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cells. Oncol Rep 2006; 16(2): 423-428.
    • (2006) Oncol Rep , vol.16 , Issue.2 , pp. 423-428
    • De Souza Nascimento, P.1    Alves, G.2    Fiedler, W.3
  • 62
    • 33746478053 scopus 로고    scopus 로고
    • Telomerase inhibition impairs tumor growth in glioblastoma xenografts
    • Falchetti ML, Fiorenzo P, Mongiardi MP, et al. Telomerase inhibition impairs tumor growth in glioblastoma xenografts. Neurol Res 2006; 28(5): 532-537.
    • (2006) Neurol Res , vol.28 , Issue.5 , pp. 532-537
    • Falchetti, M.L.1    Fiorenzo, P.2    Mongiardi, M.P.3
  • 63
    • 22144492967 scopus 로고    scopus 로고
    • Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy
    • Nakamura M, Masutomi K, Kyo S, et al. Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy. Hum Gene Ther 2005; 16(7): 859-868.
    • (2005) Hum Gene Ther , vol.16 , Issue.7 , pp. 859-868
    • Nakamura, M.1    Masutomi, K.2    Kyo, S.3
  • 64
    • 0032566005 scopus 로고    scopus 로고
    • Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
    • Kondo S, Kondo Y, Li G, Silverman RH, Cowell JK. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 1998; 16(25): 3323-3330.
    • (1998) Oncogene , vol.16 , Issue.25 , pp. 3323-3330
    • Kondo, S.1    Kondo, Y.2    Li, G.3    Silverman, R.H.4    Cowell, J.K.5
  • 65
    • 0034720202 scopus 로고    scopus 로고
    • Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component
    • Kondo Y, Koga S, Komata T, Kondo S. Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component. Oncogene 2000; 19(18): 2205-2211.
    • (2000) Oncogene , vol.19 , Issue.18 , pp. 2205-2211
    • Kondo, Y.1    Koga, S.2    Komata, T.3    Kondo, S.4
  • 66
    • 0033980773 scopus 로고    scopus 로고
    • 2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells
    • Kushner DM, Paranjape JM, Bandyopadhyay B, et al. 2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells. Gynecol Oncol 2000; 76(2): 183-192.
    • (2000) Gynecol Oncol , vol.76 , Issue.2 , pp. 183-192
    • Kushner, D.M.1    Paranjape, J.M.2    Bandyopadhyay, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.