Tetrahydroisoquinoline-based spirocyclic lactam as a type II′ β-turn inducing peptide mimetic

Journal of Organic Chemistry

Volumn 74, Issue 21, 2009, Pages 8098-8105

  Lesma, Giordano ^a   Landoni, Nicola ^a   Pilati, Tullio ^b   Sacchetti, Alessandro ^c   Silvani, Alessandra ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

^c POLITECNICO DI MILANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL CORE; CHEMICAL EQUATIONS; CHIRALITY CHEMISTRY; CIRCULAR DICHROISM; CONFORMATIONAL BEHAVIOR; IR SPECTROSCOPY; MIMETICS; PEPTIDE MIMETICS; SELF REPRODUCTION; TEMPERATURE DEPENDENCE; TETRAHYDROISOQUINOLINES; TETRAPEPTIDE; TYPE II;

AMINES; AMINO ACIDS; BIOMIMETICS; CHEMICAL REACTIONS; CIRCULAR DICHROISM SPECTROSCOPY; CONFORMATIONS; DICHROISM; ORGANIC ACIDS; PEPTIDES; STEREOCHEMISTRY;

X RAY CRYSTALLOGRAPHY;

ALANINE; HEXAPEPTIDE; LACTAM DERIVATIVE; PHENYLALANINE; TETRAHYDROISOQUINOLINE; TETRAPEPTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BETA TURN; CHIRALITY; CIRCULAR DICHROISM; DRUG CONFORMATION; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MOLECULAR MIMICRY; MOLECULAR MODEL; PEPTIDE SYNTHESIS; PICTET SPENGLER REACTION; POLYMERIZATION; PROTEIN CONFORMATION; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE DEPENDENCE; X RAY CRYSTALLOGRAPHY;

CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ISOQUINOLINES; LACTAMS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 70350707681     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901480d     Document Type: Article

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