The essential oil isolated from Artemisia capillaris prevents LPS-induced production of NO and PGE2 by inhibiting MAPK-Mediated pathways in raw 264.7 macrophages

Immunological Investigations

Volumn 38, Issue 6, 2009, Pages 483-497

  Cha, Jeong Dan ^a,b   Moon, Sang Eun ^b   Kim, Hye Young ^c   Lee, Jeong Chae ^b   Lee, Kyung Yeol ^b  

^a Yonsei University College of Dentistry   (South Korea)

^b Chonbuk National University   (South Korea)

^c Dongeul University   (South Korea)

Author keywords

Artemisia capillaris; Essential oil; Inflammation; Lipopolysaccharide; MAPKs; Transcription factor

Indexed keywords

CYCLOOXYGENASE 2; ESSENTIAL OIL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; SYNAPTOTAGMIN I;

ANIMAL CELL; ARTEMISIA; ARTEMISIA CAPILLARIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DOWN REGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; ARTEMISIA; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRIC OXIDE; OILS, VOLATILE;

EID: 70350614439     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130902936307     Document Type: Article

References (37)

1. Aniya, Y., Shimabukuro, M., Shimoji, M., Kohatsu, M., Gyamfi, M. A., Miyagi, C., Kunii, D., Takayama, F., Egashira, T. 2000. Antioxidant and hepatoprotective actions of the medicinal herb Artemisia campestris from the Okinawa Islands. Biol. Pharm. Bull. 23:309-312.
2. Caivano, M., Gorgoni, B., Cohen, P., Poli, V. 2001. The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta) and C/EBP delta transcription factors. J. Biol. Chem. 276:48693-48701.
3. Cha, J. D., Jeong, M. R., Jeong, S. I., Moon, S. E., Kim, J. Y., Kil, B. S., Song, Y. H. 2005. Chemical composition and antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris. Planta Med. 71:186-190.
4. Chen, C.,Yu, R., Owuor, E. D., Kong, A. N. 2000. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch. Pharm. Res. 23:605-612.
5. Chen, C. W., Lee, S. T., Wu, W. T., Fu, W. M., Ho, F. M., Lin, W. W. 2003. Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages. Br. J. Pharmacol. 140:1077-1087.
6. Chen, J. C., Ho, F. M., Pei-Dawn, L. C., Chen, C. P., Jeng, K. C., Hsu, H. B., Lee, S. T., Wen, T. W., Lin, W. W. 2005. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappaB and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur. J. Pharmacol. 521:9-20.
7. Choi, S. Y.,Hwang, J. H.,Park, S. Y.,Jin, Y. J.,Ko, H. C.,Moon, S. W.,Kim, S. J. 2008. Fermented guava leaf extract inhibits LPS-induced COX-2 and iNOS expression in mouse macrophage cells by inhibition of transcription factor NF-kB. Phytother. Res. 22:1030-1034.
8. D'Acquisto, F., Iuvone, T., Rombola, L., Sautebin, L. D., Rosa, M., Carnuccio, R. 1997. Involvement of NF-kB in the regulation of cyclooxygenase-2 protein expression in LPS stimulated J774 macrophages. FEBS. Lett. 418:175-178.
9. Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., Tannenbaum, S. R. 1982. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126: 131-138.
10. Guha, M., Mackman, N. 2001. LPS induction of gene expression in human monocytes. Cell Signal. 13:85-94.
11. Guzik, T. J., Korbut, R., Adamek-Guzik, T. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54:469-487.
12. Hou, D. X., Yanagita, T.,Uto, T., Masuzaki, S., Fujii, M. 2005. Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem. Pharmacol. 70:417-425.
13. Jang, S. I., Kim, H. J., Kim, Y. J., Jeong, S. I., You, Y. O. 2006a. Tanshinone IIA inhibits LPS induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIKIKK, ERK1/2, p38 and JNK pathways. Eur. J. Pharmacol. 542:1-7.
14. Jang, S. I., Kim, Y. J., Kim, H. J., Lee, J. C., Kim, H. Y., Kim, Y. C., Yun, Y. G., Yu, H. H., You, Y. O. 2006b. Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kB activation in U937 cells. Life Sci. 78:2937-2943.
15. Jang, S. I., Kim, Y. J., Lee, W. Y., Kwak, K. C., Baek, S. H., Kwak, G. B., Yun, Y. G., Kwon, T. O., Chung, H. T., Chai, K. Y. 2005. Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon gamma plus LPS. Arch. Pharm. Res. 28:203-208.
16. Kang, G., Kong, P. J., Yuh, Y. J., Lim, S. Y., Yim, S. V., Chun, W., Kim, S. S. 2004. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappaB bindings in BV2 microglial cells. J. Pharmacol. Sci. 94:325-328.
17. Karioti, A., Hadjipavlou-Litina, D., Mensah, M. L., Fleischer, T. C., Skaltsa, H. 2004. Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana. J. Agric. Food Chem. 52:8094-8098.
18. Koo, H. N., Hong, S. H., Jeong, H. J., Lee, E. H., Kim, N. G., Choi, S. D., Ra, R. W., Kim, K. S., Kang, B. K., Kim, J. J., Oh, J. G., Kim, H. M. 2002. Inhibitory effect of Artemisia capillaris on ethanol-induced cytokines (TNF-alpha, IL-1alpha) secretion in HepG2 cells. Immunopharmacol. Immunotoxicol. 24:441-453.
19. Kordali, S.,Cakir, A., Mavi, A., Kilic, H., Yildirim, A. 2005. Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish Artemisia species. J. Agric. Food Chem. 53:1408-1416.
20. Korhonen, R., Lahti, A., Kankaanranta, H., Moilanen, E. 2005. Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy 4: 471-479.
21. Kundu, J. K., Shin, Y. K., Surh, Y. J. 2006. Resveratrol modulates phorbol esterinduced proinflammatory signal transduction pathways in mouse skin in vivo: NFkappaB and AP-1 as prime targets. Biochem. Pharmacol. 72:1506-1515.
22. Liu, K. L., Chen, H. W., Wang, R. Y., Lei, Y. P., Sheen, L. Y., Lii, C. K. 2006. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kB activation in RAW 264.7 macrophages. J. Agric. Food Chem. 54:3472-3478.
23. Liu, S. F., Ye, X., Malik, A. B. 1999. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation 100:1330-1337.
24. Mariotto, S., Menegazzi, M., Suzuki, H. 2004. Biochemical aspects of nitric oxide. Curr. Pharm. Des. 10:1627-1645.
25. Moncada, S., Palmer, R. M., Higgs, E. A. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142.
26. Ohshima, H., Tazawa, H., Sylla, B. S., Sawa, T. 2005. Prevention of human cancer by modulation of chronic inflammatory processes. Mutat. Res. 591:110-122.
27. Salvemini, D., Marino, M. H. 1998. Inducible nitric oxide synthase and inflammation. Expert. Opin. Investig. Drugs 7:65-75.
28. Sebban, H., Courtois, G. 2006. NF-kappaB and inflammation in genetic disease. Biochem. Pharmacol. 72:1153-1160.
29. Shimizu, M., Deguchi. A., Joe, A. K., Mckoy, J. F., Moriwaki, H., Weinstein, I. B. 2005. EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. J. Exp. Ther. Oncol. 5:69-78. (Pubitemid 41076992)
30. Sylvestre, M., Pichette, A., Longtin, A., Nagau, F., Legault, J. 2006. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J. Ethnopharmacol. 103:99-102.
31. Tabanca1, N., Ma, G., Pasco, D. S., Bedir, E., Kirimer, N., Baser, K. H., Khan, I. A., Khan, S. I. 2007. Effect of Essential Oils and Isolated Compounds from Pimpinella Species on NF-kB: A Target for Antiinflammatory Therapy. Phytother. Res. 21:741-745.
32. Tapsell, L. C., Hemphill, I., Cobiac, L., Patch, C. S., Sullivan, D. R., Fenech, M., Roodenrys, S., Keogh, J. B., Clifton, P. M., Williams, P. G., Fazio, V. A., Inge, K. E. 2006. Health benefits of herbs and spices: the past, the present, the future:185:4-24.
33. Wang, J. Y., Wen, L. L., Huang, Y. N., Chen, Y. T., Ku, M. C. 2006. Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr. Pharm. Des. 12:3521-3533.
34. Whitmarsh, A. J., Davis, R. J. 1996. Transcription factor AP-1 regulation by mitogen activated protein kinase signal transduction pathways. J. Mol. Med. 74:589-607.
35. Woo, E. R.,Lee, J. Y.,Cho, I. J.,Kim, S. G.,Kang, K. W. 2005. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol. Res. 51:539-546.
36. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., Kwon, T. K. 2006. Differential inhibitory effects of baicalein and baicalin on LPS induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Immunobiology 211:359-368.
37. Xu, C., Shen, G., Yuan, X., Kim, J. H., Gopalkrishnan, A., Keum, Y. S., Nair, S., Kong, A. N. 2006. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis 27:437-445.