Nanogap biosensors for electrical and label-free detection of biomolecular interactions

Nanotechnology

Volumn 20, Issue 45, 2009, Pages

  Kyu Kim, Sang ^a,b   Cho, Hyunmin ^a,b   Park, Hye Jung ^a   Kwon, Dohyoung ^a   Min Lee, Jeong ^a   Hyun Chung, Bong ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPIC WET ETCHING; BIO-SENSOR PLATFORMS; BIOMOLECULAR INTERACTIONS; CURRENT INCREASE; DEVICE LAYERS; GAP SIZE; HIGHLY SENSITIVE; LABEL-FREE DETECTION; NANO-GAP; NANOMETER DISTANCE; SILICON DEVICES; SILICON ON INSULATOR WAFERS; SOI WAFERS;

ANISOTROPIC ETCHING; ANISOTROPY; BIOSENSORS; LABELS; SEMICONDUCTING SILICON COMPOUNDS; SIGNAL TRANSDUCTION; SILICON WAFERS;

WET ETCHING;

ANTIBODY; ANTIGEN; BIOTIN; SILICON; STREPTAVIDIN; NANOMATERIAL;

ANISOTROPY; ARTICLE; BIOSENSOR; MOLECULAR INTERACTION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; GENETIC PROCEDURES; METHODOLOGY; NANOTECHNOLOGY;

BIOSENSING TECHNIQUES; NANOSTRUCTURES; NANOTECHNOLOGY;

EID: 70350584983     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/20/45/455502     Document Type: Article

References (28)

1. Janasek D, Franzke J and Manz A 2006 Scaling and the design of miniaturized chemical-analysis systems Nature 442 374-80
2. Jung S O, Ro H-S, Kho B H, Shin Y-B, Kim M G and Chung B H 2005 Surface plasmon resonance imaging-based protein arrays for high-throughput screening of protein-protein interaction inhibitors Proteomics 5 4427-31
3. Dawson E D, Moore C L, Dankbar D M, Mehlmann M, Townsend M B, Smagala J A, Smith C B, Cox N J, Kuchta R D and Rowlen K L 2007 Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray Anal. Chem. 79 378-84
4. Zheng G, Patolsky F, Cui Y, Wang W U and Lieber C M 2005 Multiplexed electrical detection of cancer markers with nanowire sensor arrays Nat. Biotechnol. 23 1294-301
5. Stern E, Klemic J F, Routenberg D A, Wyrembak P N, Turner-Evans D B, Hamilton A D, LaVan D A, Fahmy T M and Reed M A 2007 Label-free immunodetection with CMOS-compatible semiconducting nanowires Nature 445 519-22
6. Star A, Gabriel J-C P, Bradley K and Gruner G 2003 Electronic detection of specific protein binding using nanotube FET devices Nano Lett. 3 459-63
7. So H-M, Won K, Kim Y H, Kim B-K, Ryu B H, Na P S, Kim H and Lee J-O 2005 Single-walled carbon nanotube biosensors using aptamers as molecular recognition elements J. Am. Chem. Soc. 127 11906-7
8. Wu G, Datar R H, Hansen K M, Thundat T, Cote R J and Majumdar A 2001 Bioassay of prostate-specific antigen (PSA) using microcantilevers Nat. Biotechnol. 19 856-60
9. Haguet V, Martin D, Marcon L, Heim T, Stievenard D, Olivier C, El-Mahdi O and Melnyk O 2004 Combined nanogap nanoparticles nanosensor for electrical detection of biomolecular interactions between polypeptides Appl. Phys. Lett. 84 1213-5
10. Im H, Huang X-J, Gu B and Choi Y-K 2007 A dielectric-modulated field-effect transistor for biosensing Nat. Nanotechnol. 2 430-4
11. Nam J-M, Thaxton C S and Mirkin C A 2003 Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins Science 301 1884-6
12. Nitzan A and Ratner M A 2003 Electron transport in molecular wire junctions Science 300 1384-9
13. Yi M, Jeong K-H and Lee L P 2005 Theoretical and experimental study towards a nanogap dielectric biosensor Biosens. Bioelectron. 20 1320-6
14. Yoo K H, Ha D H, Lee J O, Park J W, Kim J, Kim J J, Lee H Y, Kawai T and Choi H Y 2001 Electrical conduction through poly(dA)-poly(dT) and poly(dG)-poly(dC) DNA molecules Phys. Rev. Lett. 87 198102
15. Zhou C, Muller C J, Deshpande M R, Sleight J W and Reed M A 1995 Microfabrication of a mechanically controllable break junction in silicon Appl. Phys. Lett. 67 1160-2
16. Park H, Lim A K L, Alivisatos A P, Park J and McEuen P L 1999 Fabrication of metallic electrodes with nanometer separation by electromigration Appl. Phys. Lett. 75 301-3
17. Chen F, Qing Q, Ren L, Wu Z and Liu Z 2005 Electrochemical approach for fabricating nanogap electrodes with well controllable separation Appl. Phys. Lett. 86 123105
18. 2-Si nanogaps Nanotechnology 16 2197-202
19. Strobel S, Arinaga K, Hansen A and Tornow M 2005 A silicon-on-insulator vertical nanogap device for electrical transport measurements in aqueous electrolyte solution Nanotechnology 18 1983-5
20. Jaeger R C 2001 Introduction to Microelectronic Fabrication (Englewood Cliffs, NJ: Prentice-Hall)
21. Lee J M, Park H K, Jung Y, Kim J K, Jung S O and Chung B H 2007 Direct immobilization of protein G variants with various numbers of cysteine residues on a gold surface Anal. Chem. 79 2680-7
22. Tsai C, Chang T, Uppala R, Chen C, Ko F and Chen P 2005 Electrical detection of protein using gold nanoparticles and nanogap electrodes Japan. J. Appl. Phys. 44 5711
23. Chang T, Tsai C, Sun C, Chen C, Kuo L and Chen P 2007 Ultrasensitive electrical detection of protein using nanogap electrodes and nanoparticle-based DNA amplification Biosens. Bioelectron. 22 3139-45
24. Armbruster D 1993 Prostate-specific antigen: biochemistry, analytical methods, and clinical application Clin. Chem. 39 181-95
25. Okuno J, Maehashi K, Kerman K, Takamura Y, Matsumoto K and Tamiya E 2007 Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes Biosens. Bioelectron. 22 2377-81
26. Argarana C E, Kuntz I D, Birken S, Axel R and Cantor C R 1986 Molecular cloning and nucleotide sequence of the streptavidin gene Nucleic. Acids Res. 14 1871-82
27. Rosenberg B 1962 Electrical conductivity of proteins Nature 193 364-5
28. Jang D-Y, Kim Y-P, Kim H-S, Park S-H K, Choi S-Y and Choi Y-K 2007 Sublithographic vertical gold nanogap for label-free electrical detection of protein-ligand binding J. Vac. Sci. Technol. B 25 443-7