PEGylation of rhIL-1RA increased its solution stability at room temperature

Process Biochemistry

Volumn 44, Issue 12, 2009, Pages 1340-1345

  Yu, Pengzhan ^a,b   Qin, Dan ^a   Qin, Guohong ^a,b   Fan, Bei ^b   Ma, Guanghui ^b   Su, Zhiguo ^b  

^a Jiangsu Simcere Pharmaceutical R and D Co Ltd   (China)

^b INSTITUTE OF PROCESS ENGINEERING   (China)

Author keywords

Aqueous stability; Chromatography; Conformational changes; PEGylation; Recombinant human interleukin 1 receptor antagonist

Indexed keywords

AQUEOUS SOLUTIONS; AQUEOUS STABILITY; COMBINATION ANALYSIS; CONFORMATIONAL CHANGE; CONFORMATIONAL CHANGES; CYTOKINES; HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST; INFLAMMATORY DISEASE; ION EXCHANGE CHROMATOGRAPHY; PEGYLATION; PROPIONALDEHYDE; RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST; ROOM TEMPERATURE; RP-HPLC; SODIUM ACETATE; SOLUTION STABILITY; STABILITY IMPROVEMENT; STORAGE CONDITION;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; ION EXCHANGE; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYETHYLENE GLYCOLS;

STABILITY;

EID: 70350569786     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2009.07.010     Document Type: Article

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