PEGylation prevents the N-terminal degradation of megakaryocyte growth and development factor

Pharmaceutical Research

Volumn 15, Issue 12, 1998, Pages 1822-1827

  Guerra, Patricia I ^a   Acklin, Christine ^a   Kosky, Andrew A ^a   Davis, Janice M ^a   Treuheit, Michael J ^a   Brems, David N ^a  

^a AMGEN INC   (United States)

Author keywords

Cytokine; Diketopiperazine; PEGylation; rHuMGDF; Stability

Indexed keywords

MACROGOL; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; PIPERAZINEDIONE; RECOMBINANT PROTEIN;

ALKYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CYCLIZATION; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; SHELF LIFE;

ALKYLATION; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STORAGE; HUMANS; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PIPERAZINES; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TEMPERATURE; THROMBOPOIETIN;

EID: 0032409905     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011945704248     Document Type: Article

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