Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution

Biophysical Journal

Volumn 71, Issue 6, 1996, Pages 3399-3406

  Chang, Byeong S ^a   Beauvais, Robert M ^b   Arakawa, Tsutomu ^a   Narhi, Linda O ^a   Dong, Aichun ^b,c   Aparisio, Diane I ^a   Carpenter, John F ^b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF NORTHERN COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; DISULFIDE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PROTEIN;

AQUEOUS SOLUTION; ARTICLE; BIOASSAY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DIMERIZATION; DISULFIDE BOND; ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; ULTRAVIOLET SPECTROSCOPY;

EID: 0029751965     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79534-6     Document Type: Article

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