Factors that may impede the weight loss response to exercise-based interventions

Obesity Reviews

Volumn 10, Issue 6, 2009, Pages 671-680

  Boutcher, S H ^a   Dunn, S L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Exercise; Non responders; Obesity; Weight loss

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADIPONECTIN; C REACTIVE PROTEIN; CATECHOLAMINE; GHRELIN; GLUCOCORTICOID RECEPTOR; GROWTH HORMONE; HYDROCORTISONE; INSULIN; INTERLEUKIN 6; LEPTIN; LIOTHYRONINE; LIPOPROTEIN LIPASE; REACTIVE OXYGEN METABOLITE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN;

BODY COMPOSITION; BODY FAT; CALORIC INTAKE; COLD CLIMATE; CORTICOTROPIN RELEASE; DEPRESSION; DIET THERAPY; ENERGY BALANCE; ETHNICITY; EXERCISE; FOOD INTAKE; HEALTH PROGRAM; HUMAN; HYPERINSULINEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHYROIDISM; LIPID STORAGE; LOW BIRTH WEIGHT; MENTAL STRESS; MUSCLE CELL; NONHUMAN; OBESITY; REVIEW; SEX DIFFERENCE; SLEEP DEPRIVATION; WEIGHT CHANGE; WEIGHT REDUCTION;

COMBINED MODALITY THERAPY; DIET, REDUCING; ENERGY METABOLISM; EXERCISE; FEMALE; HUMANS; MALE; OBESITY; SEX FACTORS; WEIGHT LOSS;

EID: 70350549732     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2009.00621.x     Document Type: Review

References (91)

1. Andersson B, Xu XF, Rebuffe-Scrive M, Terning K, Krotkiewski M, Bjorntorp P. The effects of exercise, training on body composition and metabolism in men and women. Int J Obes 1991 15 : 75 81.
2. Stiegler P, Cunliffe A. The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Sports Med 2006 36 : 239 262.
3. Ross R, Janssen I, Dawson J, Kungl AM, Kuk JL, Wong SL, Nguyen-Duy TB, Lee S, Kilpatrick K, Hudson R. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 2004 12 : 789 798.
4. Donnelly JE, Smith BK. Is exercise effective for weight loss with ad libitum diet? Energy balance, compensation, and gender differences. Exerc Sport Sci Rev 2005 33 : 169 174.
5. King NA, Caudwell P, Hopkins M, Byrne NM, Colley R, Hills AP, Stubbs JR, Blundell JE. Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss. Obesity (Silver Spring) 2007 15 : 1373 1383.
6. Shaw K, Gennat H, O'Rourke P, Del Mar C. Exercise for overweight or obesity. Cochrane Database Syst Rev 2006 4 CD003817.
7. Janiszewski PM, Ross R. Physical activity in the treatment of obesity: beyond body weight reduction. Appl Physiol Nutr Metab 2007 32 : 512 522.
8. Miller WC, Koceja DM, Hamilton EJ. A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord 1997 21 : 941 947.
9. Ross R. Effects of diet- and exercise-induced weight loss on visceral adipose tissue in men and women. Sports Med 1997 24 : 55 64.
10. Ross R, Janssen I. Physical activity, total and regional obesity: dose-response considerations. Med Sci Sports Exerc 2001 33 : S521 7 discussion S28 9.
11. Ross R, Janssen I, Tremblay A. Obesity reduction through lifestyle modification. Can J Appl Physiol 2000 25 : 1 18.
12. Wadden TA. Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials. Ann Intern Med 1993 119 : 688 693.
13. Donnelly JE, Kirk EP, Jacobsen DJ, Hill JO, Sullivan DK, Johnson SL. Effects of 16 mo of verified, supervised aerobic exercise on macronutrient intake in overweight men and women: the Midwest Exercise Trial. Am J Clin Nutr 2003 78 : 950 956.
14. Donnelly JE, Hill JO, Jacobsen DJ, Potteiger J, Sullivan DK, Johnson SL, Heelan K, Hise M, Fennessey PV, Sonko B, Sharp T, Jakicic JM, Blair SN, Tran ZV, Mayo M, Gibson C, Washburn RA. Effects of a 16-month randomized controlled exercise trial on body weight and composition in young, overweight men and women: the Midwest Exercise Trial. Arch Intern Med 2003 163 : 1343 1350. (Pubitemid 36676200)
15. Horowitz JF, Mora-Rodriguez R, Byerley LO, Coyle EF. Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Am J Physiol. 1997 273 : E768 E775.
16. Nilsson M, Stenberg M, Frid AH, Holst JJ, Bjorck IM. Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins. Am J Clin Nutr 2004 80 : 1246 1253.
17. Dohm GL, Beeker RT, Israel RG, Tapscott EB. Metabolic responses to exercise after fasting. J Appl Physiol 1986 61 : 1363 1368.
18. Zoladz JA, Konturek SJ, Duda K, Majerczak J, Sliwowski Z, Grandys M, Bielanski W. Effect of moderate incremental exercise, performed in fed and fasted state on cardio-respiratory variables and leptin and ghrelin concentrations in young healthy men. J Physiol Pharmacol 2005 56 : 63 85.
19. Brownell KD, Greenwood MR, Stellar E, Shrager EE. The effects of repeated cycles of weight loss and regain in rats. Physiol Behav 1986 38 : 459 464.
20. Kroke A, Liese AD, Schulz M, Bergmann MM, Klipstein-Grobusch K, Hoffmann K, Boeing H. Recent weight changes and weight cycling as predictors of subsequent two year weight change in a middle-aged cohort. Int J Obes Relat Metab Disord 2002 26 : 403 409.
21. Rzehak P, Meisinger C, Woelke G, Brasche S, Strube G, Heinrich J. Weight change, weight cycling and mortality in the ERFORT Male Cohort Study. Eur J Epidemiol 2007 22 : 665 673.
22. Sorensen TI, Rissanen A, Korkeila M, Kaprio J. Intention to lose weight, weight changes, and 18-year mortality in overweight individuals without co-morbidities. PLoS Med 2005 2 : e171.
23. Froidevaux F, Schutz Y, Christin L, Jequier E. Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period. Am J Clin Nutr 1993 57 : 35 42.
24. Tremblay A, Chaput JP. About unsuspected potential determinants of obesity. Appl Physiol Nutr Metab 2008 33 : 791 796.
25. Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord 2002 26 : 1459 1464.
26. Major GC, Chaput JP, Ledoux M, St-Pierre S, Anderson GH, Zemel MB, Tremblay A. Recent developments in calcium-related obesity research. Obes Rev 2008 9 : 428 445.
27. Brand-Miller JC, Holt SH, Pawlak DB, McMillan J. Glycemic index and obesity. Am J Clin Nutr 2002 76 : 281S 5S.
28. Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 2004 1 : e62.
29. Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB. Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep 2005 28 : 1289 1296.
30. Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004 141 : 846 850.
31. Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, Wang C, Aronne LJ, Wright SM, Baskin M, Dhurandhar NV, Lijoi MC, Grilo CM, Deluca M, Westfall AO, Allison DB. Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int J Obes (Lond) 2006 30 : 1585 1594.
32. Bjorntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev 2001 2 : 73 86.
33. Bjorntorp P. Neuroendocrine perturbations as a cause of insulin resistance. Diabetes Metab Res Rev 1999 15 : 427 441.
34. McMurray RG, Hackney AC. Interactions of metabolic hormones, adipose tissue and exercise. Sports Med 2005 35 : 393 412.
35. Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002 53 : 865 871.
36. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006 17 : 4 12.
37. Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J, Bastard JP. Systemic low-grade inflammation is related to both circulating and adipose tissue TNF-alpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord 2004 28 : 993 997.
38. Sartorio A, Maffiuletti NA, Agosti F, Lafortuna CL. Gender-related changes in body composition, muscle strength and power output after a short-term multidisciplinary weight loss intervention in morbid obesity. J Endocrinol Invest 2005 28 : 494 501.
39. Mauriege P, Imbeault P, Langin D, Lacaille M, Almeras N, Tremblay A, Despres JP. Regional and gender variations in adipose tissue lipolysis in response to weight loss. J Lipid Res 1999 40 : 1559 1571.
40. Despres JP, Tremblay A, Nadeau A, Bouchard C. Physical training and changes in regional adipose tissue distribution. Acta Med Scand Suppl 1988 723 : 205 212.
41. Tai ES, Lau TN, Ho SC, Fok AC, Tan CE. Body fat distribution and cardiovascular risk in normal weight women. Associations with insulin resistance, lipids and plasma leptin. Int J Obes Relat Metab Disord 2000 24 : 751 757.
42. Forbes GB. Body fat content influences the body composition response to nutrition and exercise. Ann N Y Acad Sci 2000 904 : 359 365.
43. Goodwin P, Esplen MJ, Butler K, Winocur J, Pritchard K, Brazel S, Gao J, Miller A. Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat 1998 48 : 53 64.
44. Hansen D, Astrup A, Toubro S, Finer N, Kopelman P, Hilsted J, Rossner S, Saris W, Van Gaal L, James W, Goulder for the SSGM. Predictors of weight loss and maintenance during 2 years of treatment by sibutramine in obesity. Results from the European multi-centre STORM trial. Sibutramine Trial of Obesity Reduction and Maintenance. Int J Obes Relat Metab Disord 2001 25 : 496 501.
45. Mi J, Law C, Zhang KL, Osmond C, Stein C, Barker D. Effects of infant birthweight and maternal body mass index in pregnancy on components of the insulin resistance syndrome in China. Ann Intern Med 2000 132 : 253 260.
46. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001 414 : 782 787.
47. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P. Dynamics of fat cell turnover in humans. Nature 2008 453 : 783 787.
48. Fridlyand LE, Philipson LH. Cold climate genes and the prevalence of type 2 diabetes mellitus. Med Hypotheses 2006 67 : 1034 1041.
49. Greenway F. Virus-induced obesity. Am J Physiol Regul Integr Comp Physiol 2006 290 : R188 R189.
50. Bouchard C, Tremblay A. Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. J Nutr 1997 127 : 943S 47S.
51. Shiwaku K, Nogi A, Anuurad E, Kitajima K, Enkhmaa B, Shimono K, Yamane Y. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Int J Obes Relat Metab Disord 2003 27 : 1028 1036.
52. Park HS, Lee MS, Park JY. Leptin and the metabolic syndrome in Korean adolescents: factor analysis. Pediatr Int 2004 46 : 697 703.
53. Petersen KF, Shulman GI. Etiology of insulin resistance. Am J Med 2006 119 : S10 6.
54. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005 365 : 1415 1428.
55. Zimmet P. Epidemiology of diabetes mellitus and associated cardiovascular risk factors: focus on human immunodeficiency virus and psychiatric disorders. Am J Med 2005 118 (Suppl. 2 3S 8S.
56. Lin WY, Yang WS, Lee LT, Chen CY, Liu CS, Lin CC, Huang KC. Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan. Int J Obes (Lond) 2006 30 (6 912 917.
57. Dvorak RV, DeNino WF, Ades PA, Poehlman ET. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes 1999 48 : 2210 2214.
58. Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 1999 277 : E1130 E1141.
59. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005 307 : 384 387.
60. Fridlyand LE, Philipson LH. Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab 2006 8 : 136 145.
61. Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002 51 : 2944 2950.
62. Aas V, Rokling-Andersen M, Wensaas AJ, Thoresen GH, Kase ET, Rustan AC. Lipid metabolism in human skeletal muscle cells: effects of palmitate and chronic hyperglycaemia. Acta Physiol Scand 2005 183 : 31 41.
63. Fisler JS, Warden CH. Uncoupling proteins, dietary fat and the metabolic syndrome. Nutr Metab (Lond) 2006 3 : 38.
64. Helge JW, Fraser AM, Kriketos AD, Jenkins AB, Calvert GD, Ayre KJ, Storlien LH. Interrelationships between muscle fibre type, substrate oxidation and body fat. Int J Obes Relat Metab Disord 1999 23 : 986 991.
65. Kempen KP, Saris WH, Kuipers H, Glatz JF, Van Der Vusse GJ. Skeletal muscle metabolic characteristics before and after energy restriction in human obesity: fibre type, enzymatic beta-oxidative capacity and fatty acid-binding protein content. Eur J Clin Invest 1998 28 : 1030 1037.
66. Zierath JR, Hawley JA. Skeletal muscle fiber type: influence on contractile and metabolic properties. PLoS Biol. 2004 2 : e348.
67. Toft I, Bonaa KH, Lindal S, Jenssen T. Insulin kinetics, insulin action, and muscle morphology in lean or slightly overweight persons with impaired glucose tolerance. Metabolism 1998 47 : 848 854.
68. He J, Goodpaster BH, Kelley DE. Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res 2004 12 : 761 769.
69. Tremblay A, Despres JP, Bouchard C. The effects of exercise-training on energy balance and adipose tissue morphology and metabolism. Sports Med 1985 2 : 223 233.
70. Tremblay A, Despres JP, Leblanc C, Bouchard C. Sex dimorphism in fat loss in response to exercise training. J Obes Weight Regul 1984 3 : 193 203.
71. Tataranni PA, Young JB, Bogardus C, Ravussin E. A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obes Res 1997 5 : 341 347.
72. Spraul M, Ravussin E, Fontvieille AM, Rising R, Larson DE, Anderson EA. Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest 1993 92 : 1730 1735.
73. Prentice AM. Manipulation of dietary fat and energy density and subsequent effects on substrate flux and food intake. Am J Clin Nutr 1998 67 : 535S 41S.
74. Raben A, Holst JJ, Christensen NJ, Astrup A. Determinants of postprandial appetite sensations: macronutrient intake and glucose metabolism. Int J Obes Relat Metab Disord 1996 20 : 161 169.
75. Snitker S, Tataranni PA, Ravussin E. Respiratory quotient is inversely associated with muscle sympathetic nerve activity. J Clin Endocrinol Metab 1998 83 : 3977 3979.
76. Arciero PJ, Goran MI, Poehlman ET. Resting metabolic rate is lower in women than in men. J Appl Physiol 1993 75 : 2514 2520.
77. Bouchard C, Tremblay A, Nadeau A, Despres JP, Theriault G, Boulay MR, Lortie G, Leblanc C, Fournier G. Genetic effect in resting and exercise metabolic rates. Metabolism 1989 38 : 364 370.
78. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 1990 259 : E650 E657.
79. Seidell JC, Muller DC, Sorkin JD, Andres R. Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes Relat Metab Disord 1992 16 : 667 674.
80. Marra M, Scalfi L, Covino A, Esposito-Del Puente A, Contaldo F. Fasting respiratory quotient as a predictor of weight changes in non-obese women. Int J Obes Relat Metab Disord 1998 22 : 601 603.
81. Zambon A, Pauletto P, Crepaldi G. Review article: the metabolic syndrome - a chronic cardiovascular inflammatory condition. Aliment Pharmacol Ther 2005 22 (Suppl. 2 20 23.
82. Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, Hattersley AT, Ebrahim S, Lowe GD, Rumley A, Davey Smith G. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet 2005 366 : 1954 1959.
83. Karelis AD, Faraj M, Bastard JP, St-Pierre DH, Brochu M, Prud'homme D, Rabasa-Lhoret R. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab 2005 90 : 4145 4150.
84. Blaak EE, Hul G, Verdich C, Stich V, Martinez A, Petersen M, Feskens EF, Patel K, Oppert JM, Barbe P, Toubro S, Anderson I, Polak J, Astrup A, Macdonald IA, Langin D, Holst C, Sorensen TI, Saris WH. Fat oxidation before and after a high fat load in the obese insulin-resistant state. J Clin Endocrinol Metab 2006 91 : 1462 1469.
85. Vettor R, Milan G, Rossato M, Federspil G. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005 22 (Suppl. 2 3 10.
86. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004 50 : 1511 1525.
87. Dyck DJ, Heigenhauser GJ, Bruce CR. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf) 2006 186 : 5 16.
88. Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high-sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J 2005 52 : 89 94.
89. Imbeault P, Chevrier J, Dewailly E, Ayotte P, Despres JP, Tremblay A, Mauriege P. Increase in plasma pollutant levels in response to weight loss in humans is related to in vitro subcutaneous adipocyte basal lipolysis. Int J Obes Relat Metab Disord 2001 25 : 1585 1591.
90. Koopman-Esseboom C, Huisman M, Weisglas-Kuperus N, Boersma ER, de Ridder MA, Van der Paauw CG, Tuinstra LG, Sauer PJ. Dioxin and PCB levels in blood and human milk in relation to living areas in the Netherlands. Chemosphere 1994 29 : 2327 2338.
91. King NA, Hopkins M, Caudwell P, Stubbs RJ, Blundell JE. Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss. Int J Obes (Lond) 2008 32 : 177 184.