Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 273, Issue 4 36-4, 1997, Pages

  Horowitz, Jeffrey F ^a   Mora Rodriguez, Ricardo ^a   Byerley, Lauri O ^a   Coyle, Edward F ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Glycemic index; Insulin; Preexercise meal; Stable isotopes

Indexed keywords

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; DIETARY INTAKE; EXERCISE; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLYCOGEN MUSCLE LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; INGESTION; INSULIN RESPONSE; LIPOLYSIS; NORMAL HUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL;

EID: 0030679655     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.273.4.e768     Document Type: Article

References (16)

1. Ahlborg, G., and O. Bjorkman. Carbohydrate utilization by exercising muscle following pre-exercise glucose ingestion. Clin. Physiol. 7: 181-195, 1987.
2. Ahlborg, G., and P. Felig. Substrate utilization during prolonged exercise preceded by ingestion of glucose. Am. J. Physiol. 233 (Endocrinol. Metab. Gastrointest. Physiol. 2): E188-E194, 1977.
3. Bøje, O. Arbeithypoglykamie nach glukoseeingabe. Skand. Arch. Physiol. 83: 308-312, 1940.
4. Bonadonna, R. C., L. C. Groop, K. Zych, M. Shank, and R. A. DeFronzo. Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E736-E750, 1990.
5. Campbell, P. J., M. G. Carlson, J. O. Hill, and N. Nurjhan. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E1063-E1069, 1992.
6. Cersosimo, E., S. Coppack, and M. Jensen. Lack of effect of hyperglycemia on lipolysis in humans. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E821-E824, 1993.
7. Coggan, A. R., W. M. Kohrt, R. J. Spina, D. M. Bier, and J. O. Holloszy. Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. J. Appl. Physiol. 68: 990-996, 1990.
8. Costill, D. L., E. F. Coyle, G. Dalsky, W. Evans, W. Fink, and D. Hoopes. Effects of plasma FFA and insulin on muscle glycogen usage during exercise. J. Appl. Physiol. 43: 693-699, 1977.
9. Coyle, E. F., A. E. Jeukendrup, A. J. M. Wagenmakers, and W. H. M. Saris. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E268-E275, 1997.
10. Dyck, D. J., S. J. Peters, P. Wendling, A. Chesley, E. Hultman, and L. L. Spriet. Regulation of muscle glycogen phosphorylase activity during intense aerobic cycling with elevated FFA. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E116-E125, 1996.
11. Dyck, D. J., C. T. Putman, G. J. F. Heigenhauser, E. Hultman, and L. L. Spriet. Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E852-E859, 1993.
12. Eggstein, M., and E. Kuhlmann. Triglycerides and glycerol. Determination after alkaline hydrolysis. In: Methods of Enzymatic Analysis (2nd ed.), edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1825-1831.
13. Gollnick, P. D., B. Pernow, B. Essen, E. Jansson, and B. Saltin. Availability of glycogen and plasma FFA for substrate utilization in leg muscle of man. Clin. Physiol. 1: 27-42, 1981.
14. Hargreaves, M., D. L. Costill, W. J. Fink, D. S. King, and R. A. Fielding. Effect of pre-exercise carbohydrate feedings on endurance cycling performance. Med. Sci. Sports Exercise 19: 33-36, 1987.
15. Ivy, J. L., and J. O. Holloszy. Persistent increase in glucose uptake by rat skeletal muscle following exercise. Am. J. Physiol. 241 (Cell Physiol. 10): C200-C203, 1981.
16. Kurpad, A., K. Khan, A. G. Calder, S. Coppack, K. Frayn, and I. MacDonald. Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin. Sci. (Lond.) 86: 177-184, 1994.