Prediction of Phase i single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling

Xenobiotica

Volumn 39, Issue 9, 2009, Pages 637-648

  Gibson, C R ^a   Bergman, A ^a   Lu, P ^a   Kesisoglou, F ^a   Denney, W S ^a   Mulrooney, E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Physiologically based pharmacokinetic modelling (PBPK); Prediction; Recombinant cytochrome P450 (rCYP)

Indexed keywords

CORTISONE; CYTOCHROME P450; DICLOFENAC; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PARACETAMOL; PHENACETIN; PLACEBO; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE; DRUG; RECOMBINANT PROTEIN;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CELL STRAIN CACO 2; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG ELIMINATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MAXIMUM PLASMA CONCENTRATION; PHARMACOKINETICS; PHASE 1 CLINICAL TRIAL; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PREDICTION; TIME TO MAXIMUM PLASMA CONCENTRATION; BIOLOGICAL MODEL; BLOOD; COMPUTER SIMULATION; CONTROLLED CLINICAL TRIAL; DRUG SCREENING; LIQUID CHROMATOGRAPHY; METABOLIC CLEARANCE RATE; METABOLISM; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; CACO-2 CELLS; CHROMATOGRAPHY, LIQUID; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; HUMANS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 70350521133     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250902954296     Document Type: Article

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