Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen

Critical Reviews in Toxicology

Volumn 39, Issue 6, 2009, Pages 462-486

  Sweeney, Lisa M ^a   Kirman, Christopher R ^b   Albertini, Richard J ^c   Tan, Yu Mei ^d   Clewell III, Harvey J ^d   Filser, Johannes G ^e   Csanády, György ^e   Pottenger, Lynn H ^f   Banton, Marcy I ^g   Graham, Cynthia J ^h   Andrews, Larry S ⁱ   Papciak, Raymond J ^h   Gargas, Michael L ^a  

^a Sapphire Group   (United States)

^b Sapphire Group Inc   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

^f DOW CHEMICAL COMPANY   (United States)

^g LYONDELLBASELL INDUSTRIES   (United States)

^h Huntsman International LLC   (United States)

ⁱ ROHM AND HAAS COMPANY   (United States)

Author keywords

Cancer risk assessment; Genotoxicity; Nasal toxicity; Noncancer risk assessment

Indexed keywords

CARCINOGEN; DNA; GLUTATHIONE; PROPYLENE OXIDE;

CANCER INCIDENCE; CANCER RISK; CARCINOGENESIS; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; DOSIMETRY; EXPOSURE VARIABLE; GENOTOXICITY; HEALTH HAZARD; HUMAN; INHALATION; NONHUMAN; NOSE TUMOR; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REFERENCE VALUE; REVIEW; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS;

ANIMALS; CARCINOGENS; ENVIRONMENTAL EXPOSURE; EPOXY COMPOUNDS; HUMANS; REFERENCE VALUES; RISK ASSESSMENT; THRESHOLD LIMIT VALUES;

RATTUS; RODENTIA;

EID: 70350508532     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440902837959     Document Type: Review

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