Exposure-dependent accumulation of N-(2-hydroxypropyl)valine in hemoglobin of F344 rats exposed to propylene oxide by the inhalation route

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 778, Issue 1-2, 2002, Pages 383-391

  Rı́os Blanco, Melva N ^a,d   Ranasinghe, Asoka ^b   Upton, Patricia ^b   Lee, Moung S ^c   Filser, Johannes G ^c   Swenberg, James A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d Oral Care Research and Development   (United States)

Author keywords

Hemoglobin; N (2 Hydroxypropyl)valine; Propylene oxide

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; DNA; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDES; PROPYLENE; TISSUE; TUMORS;

INHALATION ROUTE;

HEMOGLOBIN;

BIOLOGICAL MARKER; GLOBIN; HEMOGLOBIN; N (2 HYDROXYPROPYL)VALINE; PROPYLENE OXIDE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CANCER INCIDENCE; CANCER RISK; CONTROLLED STUDY; DEGRADATION; DNA ADDUCT; DNA BINDING; DOSE RESPONSE; DOSIMETRY; GAS CHROMATOGRAPHY; LIVER; LUNG PARENCHYMA; MALE; MASS SPECTROMETRY; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; DNA ADDUCTS; EPOXY COMPOUNDS; HEMOGLOBINS; INHALATION EXPOSURE; RATS; RATS, INBRED F344; VALINE;

ANIMALIA;

EID: 0037026985     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00115-0     Document Type: Article

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