A physiological toxicokinetic model for inhaled propylene oxide in rat and human with special emphasis on the nose

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 37-62

  Csanády, György A ^a,b   Filser, Johannes G ^a,b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Glutathione; Hemoglobin and DNA adducts; Human; Physiological toxicokinetic model; Propylene oxide; Respiratory nasal mucosa; Tat

Indexed keywords

DNA; GLUTATHIONE; HEMOGLOBIN; PROPYLENE OXIDE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BLOOD FLOW; COMPARTMENT MODEL; CONJUGATION; CONTROLLED STUDY; DEPLETION; DNA ADDUCT; EXCRETION; HUMAN; HUMAN TISSUE; INHALATION; LIVER; LUNG CIRCULATION; LUNG PERFUSION; METABOLIC PARAMETERS; METABOLISM; MUSCLE; NONHUMAN; NOSE; PARTITION COEFFICIENT; PREDICTION; RAT; SIMULATION; TISSUE DISTRIBUTION; TISSUE PERFUSION; TOXICOKINETICS; VENOUS BLOOD;

AIR POLLUTANTS; ANIMALS; BIOLOGICAL MARKERS; CALIBRATION; COMPUTER SIMULATION; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; EVALUATION STUDIES; GLUTATHIONE; HEMOGLOBINS; HUMANS; INHALATION EXPOSURE; MALE; MODELS, BIOLOGICAL; NOSE; NOSE NEOPLASMS; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TISSUE DISTRIBUTION;

RODENTIA;

EID: 33845641053     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl140     Document Type: Article

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