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Volumn 114, Issue 15, 2009, Pages 3191-3198

A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; MER RECEPTOR TYROSINE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG; MERTK PROTEIN, MOUSE; ONCOPROTEIN; STAT3 PROTEIN, MOUSE;

EID: 70350445245     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-03-207522     Document Type: Article
Times cited : (28)

References (55)
  • 3
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • DOI 10.1084/jem.191.3.423
    • Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med. 2000;191(3):423-433. (Pubitemid 30693567)
    • (2000) Journal of Experimental Medicine , vol.191 , Issue.3 , pp. 423-433
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 4
    • 0037083280 scopus 로고    scopus 로고
    • Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    • Stuart LM, Lucas M, Simpson C, Lamb J, Savill J, Lacy-Hulbert A. Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation. J Immunol. 2002;168(4):1627-1635. (Pubitemid 34135757)
    • (2002) Journal of Immunology , vol.168 , Issue.4 , pp. 1627-1635
    • Stuart, L.M.1    Lucas, M.2    Simpson, C.3    Lamb, J.4    Savill, J.5    Lacy-Hulbert, A.6
  • 7
    • 27744482874 scopus 로고    scopus 로고
    • Immunoregulation of dendritic cells
    • Wallet MA, Sen P, Tisch R. Immunoregulation of dendritic cells. Clin Med Res. 2005;3(3):166-175.
    • (2005) Clin Med Res , vol.3 , Issue.3 , pp. 166-175
    • Wallet, M.A.1    Sen, P.2    Tisch, R.3
  • 8
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • Albert ML, Pearce SF, Francisco LM, et al. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med. 1998;188(7):1359-1368.
    • (1998) J Exp Med , vol.188 , Issue.7 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3
  • 11
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger RM, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res. 2008;100:35-83.
    • (2008) Adv Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 12
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • DOI 10.1126/science.1061663
    • Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science. 2001;293(5528):306-311. (Pubitemid 32694748)
    • (2001) Science , vol.293 , Issue.5528 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 13
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G, Rothlin CV. Immunobiology of the TAM receptors. Nat Rev Immunol. 2008;8(5):327-336.
    • (2008) Nat Rev Immunol , vol.8 , Issue.5 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 14
    • 0034073163 scopus 로고    scopus 로고
    • Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6
    • Ishimoto Y, Ohashi K, Mizuno K, Nakano T. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6. J Biochem (Tokyo). 2000;127(3):411-417. (Pubitemid 30185245)
    • (2000) Journal of Biochemistry , vol.127 , Issue.3 , pp. 411-417
    • Ishimoto, Y.1    Ohashi, K.2    Mizuno, K.3    Nakano, T.4
  • 16
    • 0033994339 scopus 로고    scopus 로고
    • Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells
    • Chan MC, Mather JP, McCray G, Lee WM. Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells. J Androl. 2000;21(2):291-302. (Pubitemid 30123711)
    • (2000) Journal of Andrology , vol.21 , Issue.2 , pp. 291-302
    • Chan, M.C.W.1    Mather, J.P.2    McCray, G.3    Lee, W.M.4
  • 17
    • 0041474715 scopus 로고    scopus 로고
    • The mer receptor tyrosine kinase: Expression and function suggest a role in innate immunity
    • DOI 10.1002/eji.200324076
    • Behrens EM, Gadue P, Gong SY, Garrett S, Stein PL, Cohen PL. The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur J Immunol. 2003;33(8):2160-2167. (Pubitemid 37010033)
    • (2003) European Journal of Immunology , vol.33 , Issue.8 , pp. 2160-2167
    • Behrens, E.M.1    Gadue, P.2    Gong, S.-Y.3    Garrett, S.4    Stein, P.L.5    Cohen, P.L.6
  • 18
    • 47249136911 scopus 로고    scopus 로고
    • The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus
    • Shao WH, Eisenberg RA, Cohen PL. The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol. 2008;180(11):7728- 7735.
    • (2008) J Immunol , vol.180 , Issue.11 , pp. 7728-7735
    • Shao, W.H.1    Eisenberg, R.A.2    Cohen, P.L.3
  • 21
    • 53649096545 scopus 로고    scopus 로고
    • Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa
    • Brea-Fernández AJ, Pomares E, Brion MJ, et al. Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa. Br J Ophthalmol. 2008;92(10):1419-1423.
    • (2008) Br J Ophthalmol , vol.92 , Issue.10 , pp. 1419-1423
    • Brea-Fernández, A.J.1    Pomares, E.2    Brion, M.J.3
  • 22
    • 0032926887 scopus 로고    scopus 로고
    • Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF- κB
    • Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H. Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-κB. Mol Cell Biol. 1999;19(2):1171-1181. (Pubitemid 29046859)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.2 , pp. 1171-1181
    • Georgescu, M.-M.1    Kirsch, K.H.2    Shishido, T.3    Zong, C.4    Hanafusa, H.5
  • 23
    • 0142211201 scopus 로고    scopus 로고
    • An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: A mechanism for localizing guanine nucleotide-exchange factor action
    • Mahajan NP, Earp HS. An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. J Biol Chem. 2003;278(43):42596-42603.
    • (2003) J Biol Chem , vol.278 , Issue.43 , pp. 42596-42603
    • Mahajan, N.P.1    Earp, H.S.2
  • 24
    • 0029744682 scopus 로고    scopus 로고
    • Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase
    • DOI 10.1074/jbc.271.31.18355
    • Ling L, Templeton D, Kung HJ. Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. J Biol Chem. 1996;271(31):18355-18362. (Pubitemid 26322689)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.31 , pp. 18355-18362
    • Ling, L.1    Templeton, D.2    Kung, H.-J.3
  • 26
    • 41249092199 scopus 로고    scopus 로고
    • Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation
    • Tibrewal N, Wu Y, D'mello V, et al. Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation. J Biol Chem. 2008;283(6):3618-3627.
    • (2008) J Biol Chem , vol.283 , Issue.6 , pp. 3618-3627
    • Tibrewal, N.1    Wu, Y.2    D'mello, V.3
  • 27
    • 0033559140 scopus 로고    scopus 로고
    • A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysachcharide-induced endotoxic shock
    • Camenisch TD, Koller BH, Earp HS, Matsushima GK. A novel receptor tyrosine kinase, Mer, inhibits TNF-α production and lipopolysachcharide- induced endotoxic shock. J Immunol. 1999;162(6):3498-3503.
    • (1999) J Immunol , vol.162 , Issue.6 , pp. 3498-3503
    • Camenisch, T.D.1    Koller, B.H.2    Earp, H.S.3    Matsushima, G.K.4
  • 28
    • 3843104695 scopus 로고    scopus 로고
    • Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity
    • DOI 10.1182/blood-2003-12-4302
    • Bhattacharyya S, Sen P, Wallet M, Long B, Baldwin AS Jr, Tisch R. Immunoregulation of dendritic cells by IL-10 is mediated through suppression of PI3K/Akt pathway and of IκB kinase activity. Blood. 2004;104(4):1100-1109. (Pubitemid 39038031)
    • (2004) Blood , vol.104 , Issue.4 , pp. 1100-1109
    • Bhattacharyya, S.1    Sen, P.2    Wallet, M.3    Long, B.4    Baldwin Jr., A.S.5    Tisch, R.6
  • 29
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB: A mechanism for NF-κB activation
    • Beg AA, Finco TS, Nantermet PV, Baldwin AS. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB: a mechanism for NF-κB activation. Mol Cell Biol. 1993;13(6):3301-3310. (Pubitemid 23157268)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.6 , pp. 3301-3310
    • Beg, A.A.1    Finco, T.S.2    Nantermet, P.V.3    Baldwin Jr., A.S.4
  • 30
    • 0035424898 scopus 로고    scopus 로고
    • Dendritic cells from nonobese diabetic mice exhibit a defect in NF-κB regulation due to a hyperactive IκB kinase
    • Weaver DJ, Poligone B, Bui T, Abdel-Motal UM, Baldwin AS Jr, Tisch R. Dendritic cells from NOD mice exhibit a defect in NF-κB regulation due to a hyperactive IκB kinase. J Immunol. 2001;167(3):1461-1468. (Pubitemid 32703145)
    • (2001) Journal of Immunology , vol.167 , Issue.3 , pp. 1461-1468
    • Weaver Jr., D.J.1    Poligone, B.2    Bui, T.3    Abdel-Motal, U.M.4    Baldwin Jr., A.S.5    Tisch, R.6
  • 34
    • 33745700364 scopus 로고    scopus 로고
    • Understanding and exploiting the endogenous interleukin-10/STAT3-mediated antiinflammatory response
    • Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated antiinflammatory response. Curr Opin Pharmacol. 2006;6(4):379-386.
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.4 , pp. 379-386
    • Murray, P.J.1
  • 35
    • 36849033963 scopus 로고    scopus 로고
    • TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
    • DOI 10.1016/j.cell.2007.10.034, PII S0092867407013529
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007;131(6):1124- 1136. (Pubitemid 350235020)
    • (2007) Cell , vol.131 , Issue.6 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.A.4    Lemke, G.5
  • 37
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • Yu CL, Meyer DJ, Campbell GS, et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 1995;269(5220):81-83.
    • (1995) Science , vol.269 , Issue.5220 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3
  • 38
    • 0029916933 scopus 로고    scopus 로고
    • Activation and association of Stat3 with Src in v-Src-transformed cell lines
    • Cao X, Tay A, Guy GR, Tan YH. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol. 1996;16(4):1595-1603. (Pubitemid 26095631)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.4 , pp. 1595-1603
    • Cao, X.1    Tay, A.2    Guy, G.R.3    Tan, Y.H.4
  • 39
    • 0023649678 scopus 로고
    • A tail of two Src's: Mutatis mutandis
    • Hunter T. A tail of two Src's: mutatis mutandis. Cell. 1987;49(1):1-4.
    • (1987) Cell , vol.49 , Issue.1 , pp. 1-4
    • Hunter, T.1
  • 42
    • 0029910706 scopus 로고    scopus 로고
    • Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
    • DOI 10.1074/jbc.271.47.30022
    • Nagata K, Ohashi K, Nakano T, et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky and Mer receptor tyrosine kinases. J Biol Chem. 1996;271(47):30022-30027. (Pubitemid 26389640)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.47 , pp. 30022-30027
    • Nagata, K.1    Ohashi, K.2    Nakano, T.3    Arita, H.4    Zong, C.5    Hanafusa, H.6    Mizuno, K.7
  • 43
    • 33847703719 scopus 로고    scopus 로고
    • Apoptotic Cells Inhibit LPS-Induced Cytokine and Chemokine Production and IFN Responses in Macrophages
    • DOI 10.1016/j.humimm.2006.12.008, PII S0198885906006148
    • Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB. Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages. Hum Immunol. 2007;68(3):156-164. (Pubitemid 46371335)
    • (2007) Human Immunology , vol.68 , Issue.3 , pp. 156-164
    • Tassiulas, I.1    Park-Min, K.-H.2    Hu, Y.3    Kellerman, L.4    Mevorach, D.5    Ivashkiv, L.B.6
  • 44
    • 34247580796 scopus 로고    scopus 로고
    • Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells
    • Seitz HM, Camenisch TD, Lemke G, Earp HS, Matsushima GK. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol. 2007;178(9):5635-5642. (Pubitemid 46674359)
    • (2007) Journal of Immunology , vol.178 , Issue.9 , pp. 5635-5642
    • Seitz, H.M.1    Camenisch, T.D.2    Lemke, G.3    Earp, H.S.4    Matsushima, G.K.5
  • 45
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol. 1997;13:513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 46
    • 17044362792 scopus 로고    scopus 로고
    • Functional role of c-Src in IL-1-induced NF-κB activation: C-Src is a component of the IKK complex
    • DOI 10.1093/jb/mvi018
    • Funakoshi-Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S, Kasahara T. Functional role of c-Src in IL-1-induced NF-́B activation: c-Src is a component of the IKK complex. J Biochem. 2005;137(2):189-197. (Pubitemid 40502395)
    • (2005) Journal of Biochemistry , vol.137 , Issue.2 , pp. 189-197
    • Funakoshi-Tago, M.1    Tago, K.2    Andoh, K.3    Sonoda, Y.4    Tominaga, S.-I.5    Kasahara, T.6
  • 47
    • 23844518326 scopus 로고    scopus 로고
    • The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation
    • Chu CL, Lowell CA. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol. 2005;175(5):2880-2889.
    • (2005) J Immunol , vol.175 , Issue.5 , pp. 2880-2889
    • Chu, C.L.1    Lowell, C.A.2
  • 48
    • 0034456444 scopus 로고    scopus 로고
    • Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1
    • DOI 10.1210/en.141.6.2129
    • Grey A, Chen Y, Paliwal I, Carlberg K, Insogna K. Evidence for a functional association between phosphatidylinositol 3-kinase and c-Src in the spreading response of osteoclasts to colony-stimulating factor-1. Endocrinology. 2000;141(6):2129-2138. (Pubitemid 32274366)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 2129-2138
    • Grey, A.1    Chen, Y.2    Paliwal, I.3    Carlberg, K.4    Insogna, K.5
  • 51
    • 0030802887 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
    • Goruppi S, Ruaro E, Varnum B, Schneider C. Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts. Mol Cell Biol. 1997;17(8):4442-4453. (Pubitemid 27318121)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.8 , pp. 4442-4453
    • Goruppi, S.1    Ruaro, E.2    Varnum, B.3    Schneider, C.4
  • 54
    • 42549116145 scopus 로고    scopus 로고
    • JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes
    • DOI 10.1159/000129389
    • Lu Y, Zhou J, Xu C, et al. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem. 2008;21(4):305-314. (Pubitemid 351591422)
    • (2008) Cellular Physiology and Biochemistry , vol.21 , Issue.4 , pp. 305-314
    • Lu, Y.1    Zhou, J.2    Xu, C.3    Lin, H.4    Xiao, J.5    Wang, Z.6    Yang, B.7
  • 55
    • 63849156298 scopus 로고    scopus 로고
    • MerTK regulates thymic selection of autoreactive T cells
    • Wallet MA, Flores RR, Wang Y, et al. MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci U S A. 2009;106(12):4810-4815.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.12 , pp. 4810-4815
    • Wallet, M.A.1    Flores, R.R.2    Wang, Y.3


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