Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: The role of three residues in nonsubstrate recognition sites

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 71-79

  Von Weymarn, Linda B ^a   Sridar, Chitra ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; 7 ETHOXY 4 (TRIFLUOROMETHYL)COUMARIN; AMINO ACID; COUMARIN DERIVATIVE; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; ETHER DERIVATIVE; ETHINYLESTRADIOL; HEME; LIDOCAINE; N METHYL N NITROSOANILINE; PHENOBARBITAL; SECOBARBITAL; TERT BUTYL 1 METHYL 2 PROPYNYL ETHER; UNCLASSIFIED DRUG;

ARTICLE; CHIMERA; COVALENT BOND; DRUG METABOLISM; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICHAELIS CONSTANT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ALKYNES; AMINO ACIDS; ANIMALS; CYTOCHROME P-450 CYP2B1; ENZYME INHIBITORS; ETHERS; ETHINYL ESTRADIOL; HEME; MUTATION; RATS; RECOMBINANT FUSION PROTEINS;

EID: 4644339625     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.069757     Document Type: Article

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