Dephosphorylation of p53 during cell death by N-α-tosyl-L-phenylalanyl chloromethyl ketone

Biochemical and Biophysical Research Communications

Volumn 306, Issue 4, 2003, Pages 954-958

  Kim, Karam ^a   Choi, Kyung Hee ^b   Fu, Ya Min ^c   Meadows, Gary G ^c   Joe, Cheol O ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chung Ang University   (South Korea)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; Dephosphorylation; p53; TPCK

Indexed keywords

ASPARTIC ACID DERIVATIVE; CASPASE 3; CASPASE 7; KETONE DERIVATIVE; N ALPHA TOSYLPHENYLALANYLCHLOROMETHYL KETONE; PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL STRAIN; COLORECTAL CARCINOMA; CONTROLLED STUDY; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; INCUBATION TIME; MUTANT; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION;

EID: 0038095289     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01088-X     Document Type: Article

References (25)

1. Weis M., Schlegel J., Kass G.E., Holmstrom T.H., Peters I., Eriksson J., Orrenius S., Chow S.C. Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes. Exp. Cell Res. 219:1995;699-708.
2. Huang Y., Sheikh M.S., Fornace A.J. Jr., Holbrook N.J. Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells. Oncogene. 18:1999;3431-3439.
3. Mansat V., Bettaieb A., Levade T., Laurent G., Jaffrezou J.P. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. FASEB J. 11:1997;695-702.
4. Shimizu T., Pommier Y. Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases. Leukemia. 11:1997;1238-1244.
5. Wu M., Lee H., Bellas R.E., Schauer S.L., Arsura M., Katz D., FitzGerald M.J., Rothstein T.L., Sherr D.H., Sonenshein G.E. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J. 15:1996;4682-4690.
6. Wu M., Arsura M., Bellas R.E., FitzGerald M.J., Lee H., Schauer S.L., Sherr D.H., Sonenshein G.E. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol. Cell Biol. 16:1996;5015-5025.
7. Giaccia A.J., Kastan M.B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12:1998;2973-2983.
8. Oren M. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 274:1999;36031-36034.
9. Prives C., Hall P.A. The p53 pathway. J. Pathol. 187:1999;112-126.
10. Milne D.M., Palmer R.H., Campbell D.G., Meek D.W. Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene. 7:1992;1361-1369.
11. Shieh S.Y., Ikeda M., Taya Y., Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91:1997;325-334.
12. Ko L.J., Shieh S.Y., Chen X., Jayaraman L., Tamai K., Taya Y., Prives C., Pan Z.Q. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Mol. Cell Biol. 17:1997;7220-7229.
13. Jabbur J.R., Huang P., Zhang W. DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo. Oncogene. 19:2000;6203-6208.
14. Tibbetts R.S., Brumbaugh K.M., Williams J.M., Sarkaria J.N., Cliby W.A., Shieh S.Y., Taya Y., Prives C., Abraham R.T. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:1999;152-157.
15. Oda K., Arakawa H., Tanaka T., Matsuda K., Tanikawa C., Mori T., Nishimori H., Tamai K., Tokino T., Nakamura Y., Taya Y. p53AIP1, a potential mediator of p53-dependent apoptosis, its regulation by Ser-46-phosphorylated p53. Cell. 102:2000;849-862.
16. Huang C., Ma W.Y., Maxiner A., Sun Y., Dong Z. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J. Biol. Chem. 274:1999;12229-12235.
17. Hupp T.R., Meek D.W., Midgley C.A., Lane D.P. Regulation of the specific DNA binding function of p53. Cell. 71:1992;875-886.
18. Lu H., Fisher R.P., Bailey P., Levine A.J. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53 enhancing its sequence-specific DNA binding activity in vitro. Mol. Cell Biol. 17:1997;5923-5934.
19. Takenaka I., Morin F., Seizinger B.R., Kley N. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J. Biol. Chem. 270:1995;5405-5411.
20. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 282:1998;1497-1501.
21. Shieh S.Y., Taya Y., Prives C. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization. EMBO J. 18:1999;1815-1823.
22. Sakaguchi K., Sakamoto H., Lewis M.S., Anderson C.W., Erickson J.W., Appella E., Xie D. Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry. 36:1997;10117-10124.
23. Waterman M.J., Stavridi E.S., Waterman J.L., Halazonetis T.D. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19:1998;175-178.
24. Stavridi E.S., Chehab N.H., Malikzay A., Halazonetis T.D. Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest. Cancer Res. 61:2001;7030-7033.
25. Craig A.L., Blaydes J.P., Burch L.R., Thompson A.M., Hupp T.R. Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation. Oncogene. 18:1999;6305-6312.