Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 5, 2009, Pages 383-397

  Labonte, Benoit ^a,b   Bambico, Francis Rodriguez ^a   Gobbi, Gabriella ^a  

^a MCGILL UNIVERSITY   (Canada)

^b CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

Author keywords

Electrophysiology; Glutamate; Medial prefrontal cortex (mPFC); NMDA antagonist; Ritanserin; Schizophrenia; Serotonin 2A 2C (5 HT2A 2C) receptors

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RITANSERIN; SEROTONIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; MICROIONTOPHORESIS; NERVE CELL EXCITABILITY; NERVE CELL STIMULATION; NONHUMAN; PREFRONTAL CORTEX; PYRAMIDAL NERVE CELL; RAT;

EID: 70350340102     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0446-4     Document Type: Article

References (109)

1. BW Adams B Moghaddam 2001 Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex Biol Psychiatry 50 10 750-757.
2. LE Adler A Olincy M Waldo JG Harris J Griffith K Stevens K Flach H Nagamoto P Bickford S Leonard R Freedman 1998 Schizophrenia, sensory gating, and nicotinic receptors Schizophr Bull 24 189-202. (Pubitemid 28404980)
3. GK Aghajanian GJ Marek 1999 Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release Brain Res 825 161-71.
4. GK Aghajanian GJ Marek 2000 Serotonin model of schizophrenia: emerging role of glutamate mechanisms Brain Res Brain Res Rev 31 302-312.
5. M Amargos-Bosch A Bortolozzi MV Puig J Serrats A Adell P Celada M Toth G Mengod F Artigas 2004 Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex Cereb Cortex 14 281-299. (Pubitemid 38252721)
6. M Amargos-Bosch X Lopez-Gil F Artigas A Adell 2006 Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine Int J Neuropsychopharmacol 9 565-573.
7. P Andine N Widermark R Axelsson G Nyberg U Olofsson E Martensson M Sandberg 1999 Characterisation of MK-801-induced behavior as a putative rat model of psychosis J Pharmacol Exp Ther 290 1393-1408.
8. R Araneda R Andrade 1991 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex Neuroscience 40 399-412.
9. CR Ashby Jr LH Jiang RJ Kasser RY Wang 1990 Electrophysiological characterisation of 5-hydroxytryptamine2 receptors in the rat medial prefrontal cortex J Pharmacol Exp Ther 252 171-178.
10. CR Ashby Jr E Edwards RY Wang 1994 Electrophysiological evidence for a functional interaction between 5-HT1A and 5-HT2A receptors in the rat medial prefrontal cortex: an iontophoretic study Synapse 17 173-181.
11. EC Azmitia M Segal 1978 An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat J Comp Neurol 179 641 667 565370
12. LM Barbato SG Potkin J Heisterberg PP Yeung NA Shapira 2006 A randomized, double-blind, placebo-controlled study of bifeprunox, a partial dopamine D2 receptor agonist, in patients with acute exacerbations of schizophrenia Neuropsychopharmacology 31 S251 S252
13. P Bartho H Hirase L Monconduit M Zugaro KD Harris G Buzsaki 2004 Characterisation of neocortical principal cells and interneurons by network interactions and extracellular features J Neurophysiol 92 600-608.
14. PB Bergqvist J Dong P Blier 1999 Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study Psychopharmacology (Berl) 143 89 96
15. A Breier AK Malhotra DA Pinals NI Weisenfeld D Pickar 1997 Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers Am J Psychiatry 154 805-811.
16. A Burgos-Robles I Vidal-Gonzalez E Santini GJ Quirk 2007 Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex Neuron 53 871-880.
17. ML Carlsson 1995 The selective 5-HT2A receptor antagonist MDL 100, 907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse-implications for psychosis J Neural Transm Gen Sect 100 225-237.
18. D Casey LM Barbato J Heisterberg PP Yeung NA Shapira 2006 Efficacy and safety of bifeprunox in the treatment of patients with acute exacerbations of schizophrenia: results of a dose-finding study Neuropsychopharmacology 31 S119
19. DE Casey EE Sands J Heisterberg HM Yang 2008 Efficacy and safety of bifeprunox in patients with an acute exacerbation of schizophrenia: results from a randomized, double-blind, placebo-controlled, multicenter, dose-finding study Psychopharmacology (Berl) 200 317-33.
20. I Ceglia M Carli M Baviera G Renoldi E Calcagno RW Invernizzi 2004 The 5-HT receptor antagonist M100, 907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC J Neurochem 91 189-199.
21. P Celada MV Puig JM Casanovas G Guillazo F Artigas 2001 Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABA(A), and glutamate receptors J Neurosci 21 9917-9929.
22. AJ Cochilla S Alford 1998 Metabotropic glutamate receptor-mediated control of neurotransmitter release Neuron 20 1007-1016.
23. DC Cooper 2002 The significance of action potential bursting in the brain reward circuit Neurochem Int 41 333-340.
24. B Dean 2002 Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue Postgrad Med J 78 142-148.
25. B Dean W Hayes C Hill D Copolov 1998 Decreased serotonin2A receptors in Brodmann's area 9 from schizophrenic subjects. A pathological or pharmacological phenomenon? Mol Chem Neuropathol 34 133-145.
26. M el Mansari P Blier 1997 In vivo electrophysiological characterisation of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex Neuropharmacology 36 577-588.
27. DW Gallager GK Aghajanian 1976 Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin Eur J Pharmacol 39 357 364 10174
28. MA Geyer K Krebs-Thomson DL Braff NR Swerdlow 2001 Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Psychopharmacology (Berl) 156 117-15.
29. SD Gleason HE Shannon 1997 Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice Psychopharmacology (Berl) 129 79 84
30. Glennon RA, Dukat M, Westkaemper RB (2000) Serotonin receptor subtypes and ligands. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology. The fourth generation of progress. Raven Press Ltd, New York
31. G Gobbi L Janiri 2006 Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex Psychopharmacology (Berl) 185 255-26.
32. J Gonzalez-Maeso RL Ang T Yuen P Chan NV Weisstaub JF Lopez-Gimenez M Zhou Y Okawa LF Callado G Milligan JA Gingrich M Filizola JJ Meana SC Sealfon 2008 Identification of a serotonin/glutamate receptor complex implicated in psychosis Nature 452 93-97.
33. A Gratton BJ Hoffer R Freedman 1987 Electrophysiological effects of phencyclidine in the medial prefrontal cortex of the rat Neuropharmacology 26 1275-1283.
34. HJ Groenewegen HW Berendse JG Wolters AH Lohman 1990 The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization Prog Brain Res 85 95-116
35. TJ Grudt CE Jahr 1990 Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture Mol Pharmacol 37 477-481.
36. HC Grunze DG Rainnie ME Hasselmo E Barkai EF Hearn RW McCarley RW Greene 1996 NMDA-dependent modulation of CA1 local circuit inhibition J Neurosci 16 2034-2043.
37. EV Gurevich JN Joyce 1997 Alterations in the cortical serotonergic system in schizophrenia: a postmortem study Biol Psychiatry 42 529-545.
38. M Hajos CD Richards AD Szekely T Sharp 1998 An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat Neuroscience 87 95 108.
39. M Hajos SE Gartside V Varga T Sharp 2003 In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors Neuropharmacology 45 72-81.
40. PJ Harrison MJ Owen 2003 Genes for schizophrenia? Recent findings and their pathophysiological implications Lancet 361 417-419.
41. I Herrero MT Miras-Portugal J Sanchez-Prieto 1992 Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation Nature 360 163-166.
42. H Homayoun B Moghaddam 2006 Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors Cereb Cortex 16 93 105.
43. JE Huetter PB Bean 1988 Block of N-methyl-D-aspartate- activated current by the anticonvulsant MK-801: selective binding to open channels Proc Natl Acad Sci U S A 85 1307-131.
44. GW Huntley JC Vickers JH Morrison 1994 Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in neocortex: organizational features related to cortical circuitry, function and disease Trends Neurosci 17 536-543.
45. ME Jackson H Homayoun B Moghaddam 2004 NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex Proc Natl Acad Sci U S A 101 8467-8472.
46. RL Jakab PS Goldman-Rakic 1998 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites Proc Natl Acad Sci U S A 95 735-740.
47. RL Jakab PS Goldman-Rakic 2000 Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex J Comp Neurol 417 337-348.
48. TM Jay MP Witter 1991 Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin J Comp Neurol 313 574-586.
49. TM Jay AM Thierry L Wiklund J Glowinski 1992 Excitatory amino acid pathway from the hippocampus to the prefrontal cortex. Contribution of AMPA receptors in hippocampo-prefrontal cortex transmission Eur J Neurosci 4 1285-1295.
50. JD Jentsch RH Roth 1999 The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia Neuropsychopharmacology 20 201-225.
51. E Jodo C Chiang G Aston-Jones 1998 Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons Neuroscience 83 63-79.
52. E Jodo Y Suzuki S Takeuchi S Niwa Y Kayama 2003 Different effects of phencyclidine and methamphetamine on firing activity of medial prefrontal cortex neurons in freely moving rats Brain Res 962 226-231.
53. S Kapur G Remington 1996 Serotonin-dopamine interaction and its relevance to schizophrenia Am J Psychiatry 153 466-476.
54. L Kargieman N Santana G Mengod P Celada F Artigas 2007 Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine Proc Natl Acad Sci U S A 104 14843-14848.
55. A Kashiwa T Nishikawa K Nishijima A Umino K Takahashi 1995 Dizocilpine (MK-801) elicits a tetrodotoxin-sensitive increase in extracellular release of dopamine in rat medial frontal cortex Neurochem Int 26 269-279.
56. JH Kehne HJ Ketteler TC McCloskey CK Sullivan MW Dudley CJ Schmidt 1996 Effects of the selective 5-HT2A receptor antagonist MDL 100, 907 on MDMA-induced locomotor stimulation in rats Neuropsychopharmacology 15 116-124.
57. KA Krobert FO Levy 2002 The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects Br J Pharmacol 135 1563-1571.
58. JH Krystal DC D'Souza D Mathalon E Perry A Belger R Hoffman 2003 NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development Psychopharmacology (Berl) 169 215-23.
59. I Kusumi Y Takahashi K Suzuki K Kameda T Koyama 2000 Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain J Neural Transm 107 295-302.
60. AC Lahti B Koffel D LaPorte CA Tamminga 1995 Subanesthetic doses of ketamine stimulate psychosis in schizophrenia Neuropsychopharmacology 13 9 19.
61. AC Lahti MA Weiler BA Tamara Michaelidis A Parwani CA Tamminga 2001 Effects of ketamine in normal and schizophrenic volunteers Neuropsychopharmacology 25 455-467.
62. SR Laviolette WJ Lipski AA Grace 2005 A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input J Neurosci 25 6066-6075.
63. F Lejeune A Gobert JM Rivet MJ Millan 1994 Blockade of transmission at NMDA receptors facilitates the electrical and synthetic activity of ascending serotoninergic neurones Brain Res 656 427-431.
64. Q Li S Clark DV Lewis WA Wilson 2002 NMDA receptor antagonists dis-inhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity J Neurosci 22 3070-3080.
65. JA Lieberman TS Stroup JP McEvoy MS Swartz RA Rosenheck DO Perkins RS Keefe SM Davis CE Davis BD Lebowitz J Severe JK Hsiao 2005 Effectiveness of antipsychotic drugs in patients with chronic schizophrenia N Engl J Med 353 1209-1223.
66. J Liu B Moghaddam 1995 Regulation of glutamate efflux by excitatory amino acid receptors: evidence for tonic inhibitory and phasic excitatory regulation J Pharmacol Exp Ther 274 1209-1215.
67. X Lopez-Gil Z Babot M Amargos-Bosch C Sunol F Artigas A Adell 2007 Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat Neuropsychopharmacology 32 2087-2097.
68. DS Lorrain CS Baccei LJ Bristow JJ Anderson MA Varney 2003 Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268 Neuroscience 117 697-706.
69. RS Mansbach MA Geyer 1989 Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat Neuropsychopharmacology 2 299-308.
70. P Martin ML Carlsson S Hjorth 1998 Systemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats NeuroReport 9 2985-2988.
71. P Martin N Waters CJ Schmidt A Carlsson ML Carlsson 1998b Rodent data and general hypothesis: antipsychotic action exerted through 5-Ht2A receptor antagonism is dependent on increased serotonergic tone J Neural Transm 105 365-39.
72. S Maurel-Remy K Bervoets MJ Millan 1995 Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100, 907 in rats reflects antagonism of 5-HT2A receptors Eur J Pharmacol 280 R9 11.
73. CB McCracken AA Grace 2007 High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo J Neurosci 27 12601-12610.
74. VB McGinty AA Grace 2007 Selective activation of medial prefrontal-to-accumbens projection neurons by amygdala stimulation and pavlovian conditioned stimuli Cereb Cortex 18 8 1961-1972.
75. A Mechri M Saoud G Khiari T d'Amato J Dalery L Gaha 2001 Glutaminergic hypothesis of schizophrenia: clinical research studies with ketamine Encephale 27 53-59.
76. HY Meltzer 1999 The role of serotonin in antipsychotic drug action Neuropsychopharmacology 21 106S 115S.
77. HY Meltzer T Sumiyoshi 2008 Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behav Brain Res 195 98 102.
78. HY Meltzer Z Li Y Kaneda J Ichikawa 2003 Serotonin receptors: their key role in drugs to treat schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 27 1159-1172.
79. MJ Millan 2000 Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors J Pharmacol Exp Ther 295 853-861.
80. A Miwa HP Robinson N Kawai 1993 Presynaptic glutamate receptors depress inhibitory postsynaptic transmission in lobster neuromuscular synapse J Neurophysiol 70 1159-1167.
81. B Moghaddam B Adams A Verma D Daly 1997 Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex J Neurosci 17 2921-2927.
82. DT Monaghan CW Cotman 1986 Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes Proc Natl Acad Sci U S A 83 7532-7536.
83. HA Muntasir MA Bhuiyan M Ishiguro M Ozaki T Nagatomo 2006 Inverse agonist activity of sarpogrelate, a selective 5-HT2A-receptor antagonist, at the constitutively active human 5-HT2A receptor J Pharmacol Sci 102 189-195.
84. JW Olney NB Farber 1995 NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia Neuropsychopharmacology 13 335-345.
85. HJ Olverman AW Jones JC Watkins 1984 L-glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes Nature 307 460-462.
86. JF Padin MA Rodriguez E Dominguez IG Dopeso-Reyes M Buceta E Cano E Sotelo J Brea HJ Caruncho M Isabel Cadavid M Castro M Isabel Loza 2006 Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells Neuropharmacology 51 923-932.
87. M Pallotta J Segieth PS Whitton 1998 N-methyl-d-aspartate receptors regulate 5-HT release in the raphe nuclei and frontal cortex of freely moving rats: differential role of 5-HT1A autoreceptors Brain Res 783 173-178.
88. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. San Diego Academic, San Diego
89. C Peyron JM Petit C Rampon M Jouvet PH Luppi 1998 Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods Neuroscience 82 443-468.
90. D Pralong E Tomaskovic-Crook K Opeskin D Copolov B Dean 2000 Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia Schizophr Res 44 35-45.
91. MV Puig F Artigas P Celada 2005 Modulation of the activity of pyramidal neurons in rat prefrontal cortex by raphe stimulation in vivo: involvement of serotonin and GABA Cereb Cortex 15 1-14.
92. M Rapaport LM Barbato J Heisterberg PP Yeung NA Shapira 2006 Efficacy and safety of bifeprunox versus placebo in the treatment of patients with acute exacerbations of schizophrenia Neuropsychopharmacology 31 S184
93. LE Rueter LH Tecott P Blier 2000 In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice Naunyn Schmiedebergs Arch Pharmacol 361 484-491.
94. D Rujescu A Bender M Keck AM Hartmann F Ohl H Raeder I Giegling J Genius RW McCarley HJ Moller H Grunze 2006 A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities Biol Psychiatry 59 721-729.
95. JP Rung A Carlsson K Ryden Markinhuhta ML Carlsson 2005 (+)-MK-801 induced social withdrawal in rats; a model for negative symptoms of schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 29 827-832.
96. F Sams-Dodd 1996 Phencyclidine-induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia Behav Pharmacol 7 3 23.
97. N Santana A Bortolozzi J Serrats G Mengod F Artigas 2004 Expression of serotonin1A and serotonin2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex Cereb Cortex 14 1100-1109. (Pubitemid 39258165)
98. R Schreiber M Brocco V Audinot A Gobert S Veiga MJ Millan 1995 (1-(2, 5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists J Pharmacol Exp Ther 273 101-112.
99. K Schwabe M Koch 2004 Role of the medial prefrontal cortex in N-methyl-D-aspartate receptor antagonist induced sensorimotor gating deficit in rats Neurosci Lett 355 5 8.
100. NE Schwartz S Alford 2000 Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release J Neurophysiol 84 415-427.
101. H Silver P Feldman W Bilker RC Gur 2003 Working memory deficit as a core neuropsychological dysfunction in schizophrenia Am J Psychiatry 160 1809-1816.
102. Y Suzuki E Jodo S Takeuchi S Niwa Y Kayama 2002 Acute administration of phencyclidine induces tonic activation of medial prefrontal cortex neurons in freely moving rats Neuroscience 114 769-779.
103. KY Tseng P O'Donnell 2007 D2 dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex Synapse 61 843-850.
104. A Vezzani R Serafini MA Stasi S Caccia I Conti RV Tridico R Samanin 1989 Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats J Pharmacol Exp Ther 249 278-283.
105. E Vieta M Bourin R Sanchez R Marcus E Stock R McQuade W Carson N Abou-Gharbia R Swanink T Iwamoto G Aripoprazole Study 2005 Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial Br J Psychiatry 187 235-242.
106. RY Wang C de Montigny BI Gold RH Roth GK Aghajanian 1979 Denervation supersensitivity to serotonin in rat forebrain: single cell studies Brain Res 178 479 497 509215
107. DL Willins HY Meltzer 1997 Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats J Pharmacol Exp Ther 282 699-706.
108. CR Yang JK Seamans N Gorelova 1999 Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex Neuropsychopharmacology 21 161-194.
109. Y Yonezawa T Kuroki T Kawahara N Tashiro H Uchimura 1998 Involvement of gamma-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex Eur J Pharmacol 341 45 56.