In vivo electrophysiological characterization 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 577-588

  El Mansari, M ^a   Blier, P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

2 Methyl 5 HT; 5 HT receptors; 8 OH DPAT; DOI; Head of caudate nucleus; mCPP; Metergoline; Obsessive compulsive disorder; Orbitofrontal cortex; Ritanserin; Sumatriptan; WAY100635

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; GEPIRONE; METERGOLINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; QUISQUALIC ACID; RECEPTOR SUBTYPE; RICASETRON; RITANSERIN; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SUMATRIPTAN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CONTROLLED STUDY; DRUG ANTAGONISM; GUINEA PIG; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; IONTOPHORESIS; MALE; MICROIONTOPHORESIS; MINIPUMP; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; OBSESSION; ORBITAL CORTEX; PRIORITY JOURNAL; SINGLE UNIT ACTIVITY;

ANIMALS; CAUDATE NUCLEUS; ELECTROPHYSIOLOGY; GUINEA PIGS; INJECTIONS, INTRAVENOUS; IONTOPHORESIS; MALE; NEURONS; PREFRONTAL CORTEX; RECEPTORS, PRESYNAPTIC; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030941213     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00035-X     Document Type: Article

References (56)

1. 1A receptor gene. Journal of Biology and Chemistry 265: 5825-5832.
2. 3-like receptors in the rat medial prefrontal cortex: an electrophysiological study. Brain Research 550: 181-191.
3. 2 receptors in the rat medial prefrontal cortex. Journal of Pharmacology and Experimental Therapeutics 252: 171-178.
4. Aulakh C. S., Hill J. L. and Murphy D. L. (1992) Effects of various serotonin receptor subtype-selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. Journal of Pharmacology and Experimental Therapeutics 263: 588-595.
5. 2-antagonist. Drug Development and Research 15: 61-73.
6. Bagdy G., Sved A. F., Murphy D. L. and Szemeredi K. (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. European Journal of Pharmacology 210: 285-289.
7. Baxter L. R. Jr., Phelps J. M., Mazziotta J. C., Guze B. H. and Schwartz J. M. (1987) Local cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression and normal controls. Archives of General Psychiatry 44: 211-218.
8. Baxter L. R. Jr., Schwartz J. M., Bergman K. S., Szuba M. P., Guze B. H., Mazziotta J. C., Alazraki A., Selin C. E., Ferng H.-K., Munford P. and Phelps M. E. (1992) Caudate glucose metabolic rate changes with both drug and behavioral therapy for obsessive-compulsive disorder. Archives of General Psychiatry 49: 681-689.
9. Benkelfat C., Murphy D. L., Zohar J., Hill J. L., Grover G. and Insel T. R. (1989) Clomipramine in obsessive-compulsive disorder: further evidence for a serotonergic mechanism of action. Archives of General Psychiatry 46: 23-28.
10. Benkelfat C., Nordahl T. E., Semple W. E., King C., Murphy D. L. and Cohen R. M. (1990) Local cerebral glucose metabolic rates in obsessive-compulsive disorder: patients treated with clomipramine. Archives of General Psychiatry 47: 840-848.
11. Blier P., Steinberg S., Chaput Y. and de Montigny C. (1989) Electrophysiological assessement of putative antagonists of 5-HT receptors: a single-cell study in the rat dorsal raphe nucleus. Canadian Journal of Physiology and Pharmacology 67: 98-105.
12. 1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. Journal of Pharmacology and Experimental Therapeutics 265: 7-15.
13. Blier P. and Bouchard C. (1994) Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs. British Journal of Pharmacology 113: 485-195.
14. 1F receptor messenger RNA in rodent and primate brain. Neuropharmacology 33: 367-386.
15. 1 receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. Journal of Pharmacology and Experimental Therapeutics 246: 359-370.
16. Charney D. S., Goodman W. K., Price L. H., Woods S. W., Rasmussen S. A. and Heninger G. R. (1988) Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Archives of General Psychiatry 45: 177-185.
17. 1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. Journal of Pharmacology and Experimental Therapeutics 277: 1259-1266.
18. (1C) receptors. Trends in Pharmacological Science 11: 181-182.
19. El Mansari M., Radja F., Ferron A., Reader T. A., Molina-Holgado E. and Descarries L. (1994) Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European Journal of Pharmacology 261: 171-178.
20. El Mansari M., Bouchard C. and Blier P. (1995) Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology 13: 117-127.
21. 1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British Journal of Pharmacology 118: 681-689.
22. 2 receptor and fluvoxamine effect in obsessive-compulsive disorder. Human Psychopharmacology 7: 287-289.
23. 1A receptor anatgonist. Behavior and Brain Research 73: 337-353.
24. 2 receptor antagonist, RP62203, selectively blocks serotoninergic but not dopaminergic-induced inhibition in the rat prefrontal cortex. European Journal of Pharmacology 204: 97-100.
25. Goodman W. K., Price L. H., Rasmussen S. A., Delgado P. L., Heninger G. R. and Charney D. S. (1989) Efficacy of fluvoxamine in obsessive-compulsive disorder: a double-blind comparison with placebo. Archives of General Psychiatry 46: 36-44.
26. Greenberg B., Benjamin J. and Murphy D. (1994) Metergoline biphasically enhances, then antagonizes, fluoxetine's therapeutic effects in obsessive-compulsive disorder. Neuropsychopharmacology 10: 256S.
27. 3 agonist 2- methyl-5-HT on the 5-HT system in the rat brain. Synapse 20: 54-67.
28. Haigler H. J. and Aghajanian G. K. (1974) Peripheral serotonin antagonists: failure to antagonize serotonin in brain area receiving a prominent serotonergic input. Journal of Neural Transmission 35: 257-273.
29. 1D receptors in rat brain. Brain Research 483: 155-157.
30. Hollander E., DeCaria C. M., Nitescu A., Gully R., Suckow R. F., Cooper T. B., Gorman J. M., Klein D. F. and Liebowitz M. R. (1992) Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Archives of General Psychiatry 49: 21-28.
31. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R. and Humphrey P. P. A. (1994) VI. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Review 46: 157-203.
32. Insel T. R. (1992) Toward a neuroanatomy of obsessive-compulsive disorder. Archives of General Psychiatry 49: 739-744.
33. Lakoski J. M. and Aghajanian G. K. (1985) Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology 24: 265-273.
34. 2 antagonist. Molecular Pharmacology 27: 600-611.
35. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11: 449-458.
36. 1A receptors in the dorsal raphe nucleus. European Journal of Pharmacology 149: 9-15.
37. Luthman J., Friedmann M., Bickford P., Olson L., Hoffer B. J. and Gerhardt G. A. (1993) In vivo electrochemical measurements and electrophysiological studies of rat striatum following neonatal 6-hydroxydopamine treatment. Neuroscience 52: 677-687.
38. Luparello T. J. (1967) Stereotaxic Atlas of the Forebrain of the Guinea Pig. Williams and Wilkins, Baltimore.
39. 1 sites in the rat brain. Brain Research 291: 159-163.
40. 2 receptors. European Journal of Pharmacology 145: 31-38.
41. Montgomery S. A. and Manceaux A. (1992) Fluvoxamine in the treatment of obsessive compulsive disorder. International Clinical Psychopharmacology 7 (Suppl 1): 5-9.
42. 3H]5-hydroxytryptamine. Neuroscience 6): 115-138.
43. Paxinos, A. and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
44. Radja F., Laporte A.-M., Daval G., Vergé D., Gozlan H. and Hamon M. (1991) Autoradiography of serotonin receptor subtypes in the central nervous system. Neurochemistry International 18: 1-15.
45. Rauch S. L., Jenike M. A., Alpert N. M., Baer L., Breiter H. C. R., Savage C. R. and Fischman A. J. (1994) Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Archives of General Psychiatry 51: 62-70.
46. Segal M. (1976) 5-HT antagonists in rat hippocampus. Brain Research 103: 161-166.
47. 1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis. Neuropharmacology 34: 377-382.
48. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology 33: 393-402.
49. Stolz J. F. and Marsden C. A. (1982) Withdrawal from chronic treatment with metergoline, dl-propranolol and amitriptyline enhances serotonin receptor mediated behaviour in the rat. European Journal of Pharmacology 79: 17-22.
50. Swedo S. E., Pietrini P., Leonard H. L., Schapiro M. B., Rettew D. C., Goldberger E. L., Rapoport S. I., Rapoport J. L. and Grady C. L. (1992) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder: revisualization during pharmacotherapy. Archives of General Psychiatry 49: 690-694.
51. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. Journal of Neuroscience 12: 3474-3482.
52. 1D receptors in the guinea pig brain: pre- and postsynaptic localizations in the striatonigral pathway. Brain Research 528: 197-206.
53. 1A receptor agonists and antagonists on dorsal vagal preganglionic neurones in anesthetized rats: an iontophoretic study. British Journal of Pharmacology 116: 2291-2297.
54. Wang R. Y. and Aghajanian G. K. (1977) Inhibition of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain Research 120: 85-102.
55. Zohar J. and Insel T. R. (1987) Obsessive-compulsive disorder: Psychobiological approach to diagnosis, treatment, and pathophysiology. Biology and Psychiatry 22: 667-687.
56. Zohar J., Sasson Y., Cohen R. and Kindler S. (1996) New insights to the serotonin hypothesis of OCD. Collegium of Internationale Neuropsychopharmacologicum Abstract 6: 91.