메뉴 건너뛰기




Volumn 64, Issue 2, 2009, Pages 227-239

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

Author keywords

CELLBIO; MOLIMMUNO; SIGNALING

Indexed keywords

CELL PROTEIN; NEUROTRANSMITTER; PROTEIN ELKS2ALPHA; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CALCIUM; CARRIER PROTEIN; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; NERVE PROTEIN; RAB6IP2 PROTEIN, MOUSE; RIMS1 PROTEIN, MOUSE;

EID: 70350187100     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2009.09.019     Document Type: Article
Times cited : (89)

References (57)
  • 3
    • 0033615054 scopus 로고    scopus 로고
    • Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
    • Augustin I., Rosenmund C., Südhof T.C., and Brose N. Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature 400 (1999) 457-461
    • (1999) Nature , vol.400 , pp. 457-461
    • Augustin, I.1    Rosenmund, C.2    Südhof, T.C.3    Brose, N.4
  • 5
    • 34547725729 scopus 로고    scopus 로고
    • Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission
    • Bronk P., Deak F., Wilson M.C., Liu X., Südhof T.C., and Kavalali E.T. Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission. J. Neurophysiol. 98 (2007) 794-806
    • (2007) J. Neurophysiol. , vol.98 , pp. 794-806
    • Bronk, P.1    Deak, F.2    Wilson, M.C.3    Liu, X.4    Südhof, T.C.5    Kavalali, E.T.6
  • 6
    • 2942752010 scopus 로고    scopus 로고
    • Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release
    • Calakos N., Schoch S., Südhof T.C., and Malenka R.C. Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron 42 (2004) 889-896
    • (2004) Neuron , vol.42 , pp. 889-896
    • Calakos, N.1    Schoch, S.2    Südhof, T.C.3    Malenka, R.C.4
  • 7
    • 4043126769 scopus 로고    scopus 로고
    • Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy
    • Cao Y.Q., Piedras-Renteria E.S., Smith G.B., Chen G., Harata N.C., and Tsien R.W. Presynaptic Ca2+ channels compete for channel type-preferring slots in altered neurotransmission arising from Ca2+ channelopathy. Neuron 43 (2004) 387-400
    • (2004) Neuron , vol.43 , pp. 387-400
    • Cao, Y.Q.1    Piedras-Renteria, E.S.2    Smith, G.B.3    Chen, G.4    Harata, N.C.5    Tsien, R.W.6
  • 9
    • 0037986346 scopus 로고    scopus 로고
    • Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    • Chevaleyre V., and Castillo P.E. Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. Neuron 38 (2003) 461-472
    • (2003) Neuron , vol.38 , pp. 461-472
    • Chevaleyre, V.1    Castillo, P.E.2
  • 10
    • 34249691285 scopus 로고    scopus 로고
    • Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha
    • Chevaleyre V., Heifets B.D., Kaeser P.S., Südhof T.C., and Castillo P.E. Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron 54 (2007) 801-812
    • (2007) Neuron , vol.54 , pp. 801-812
    • Chevaleyre, V.1    Heifets, B.D.2    Kaeser, P.S.3    Südhof, T.C.4    Castillo, P.E.5
  • 11
    • 33845259344 scopus 로고    scopus 로고
    • SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS
    • Dai Y., Taru H., Deken S.L., Grill B., Ackley B., Nonet M.L., and Jin Y. SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Nat. Neurosci. 9 (2006) 1479-1487
    • (2006) Nat. Neurosci. , vol.9 , pp. 1479-1487
    • Dai, Y.1    Taru, H.2    Deken, S.L.3    Grill, B.4    Ackley, B.5    Nonet, M.L.6    Jin, Y.7
  • 12
    • 7944229497 scopus 로고    scopus 로고
    • Synaptobrevin is essential for fast synaptic-vesicle endocytosis
    • Deak F., Schoch S., Liu X., Südhof T.C., and Kavalali E.T. Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat. Cell Biol. 6 (2004) 1102-1108
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1102-1108
    • Deak, F.1    Schoch, S.2    Liu, X.3    Südhof, T.C.4    Kavalali, E.T.5
  • 14
    • 21344453975 scopus 로고    scopus 로고
    • Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans
    • Deken S.L., Vincent R., Hadwiger G., Liu Q., Wang Z.W., and Nonet M.L. Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. J. Neurosci. 25 (2005) 5975-5983
    • (2005) J. Neurosci. , vol.25 , pp. 5975-5983
    • Deken, S.L.1    Vincent, R.2    Hadwiger, G.3    Liu, Q.4    Wang, Z.W.5    Nonet, M.L.6
  • 15
    • 3042523535 scopus 로고    scopus 로고
    • Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit
    • Ducut Sigala J.L., Bottero V., Young D.B., Shevchenko A., Mercurio F., and Verma I.M. Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science 304 (2004) 1963-1967
    • (2004) Science , vol.304 , pp. 1963-1967
    • Ducut Sigala, J.L.1    Bottero, V.2    Young, D.B.3    Shevchenko, A.4    Mercurio, F.5    Verma, I.M.6
  • 16
    • 0035972784 scopus 로고    scopus 로고
    • A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor
    • Fowler S.C., Birkestrand B.R., Chen R., Moss S.J., Vorontsova E., Wang G., and Zarcone T.J. A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J. Neurosci. Methods 107 (2001) 107-124
    • (2001) J. Neurosci. Methods , vol.107 , pp. 107-124
    • Fowler, S.C.1    Birkestrand, B.R.2    Chen, R.3    Moss, S.J.4    Vorontsova, E.5    Wang, G.6    Zarcone, T.J.7
  • 17
    • 0028061861 scopus 로고
    • Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
    • Geppert M., Goda Y., Hammer R.E., Li C., Rosahl T.W., Stevens C.F., and Südhof T.C. Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79 (1994) 717-727
    • (1994) Cell , vol.79 , pp. 717-727
    • Geppert, M.1    Goda, Y.2    Hammer, R.E.3    Li, C.4    Rosahl, T.W.5    Stevens, C.F.6    Südhof, T.C.7
  • 20
    • 33845646925 scopus 로고    scopus 로고
    • Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family
    • Ho A., Morishita W., Atasoy D., Liu X., Tabuchi K., Hammer R.E., Malenka R.C., and Südhof T.C. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J. Neurosci. 26 (2006) 13089-13101
    • (2006) J. Neurosci. , vol.26 , pp. 13089-13101
    • Ho, A.1    Morishita, W.2    Atasoy, D.3    Liu, X.4    Tabuchi, K.5    Hammer, R.E.6    Malenka, R.C.7    Südhof, T.C.8
  • 22
    • 4043075637 scopus 로고    scopus 로고
    • Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity
    • Junge H.J., Rhee J.S., Jahn O., Varoqueaux F., Spiess J., Waxham M.N., Rosenmund C., and Brose N. Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell 118 (2004) 389-401
    • (2004) Cell , vol.118 , pp. 389-401
    • Junge, H.J.1    Rhee, J.S.2    Jahn, O.3    Varoqueaux, F.4    Spiess, J.5    Waxham, M.N.6    Rosenmund, C.7    Brose, N.8
  • 23
    • 58149388899 scopus 로고    scopus 로고
    • RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions
    • Kaeser P.S., Kwon H.B., Chiu C.Q., Deng L., Castillo P.E., and Südhof T.C. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J. Neurosci. 28 (2008) 13435-13447
    • (2008) J. Neurosci. , vol.28 , pp. 13435-13447
    • Kaeser, P.S.1    Kwon, H.B.2    Chiu, C.Q.3    Deng, L.4    Castillo, P.E.5    Südhof, T.C.6
  • 24
    • 0037187643 scopus 로고    scopus 로고
    • Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis
    • Kaufmann N., DeProto J., Ranjan R., Wan H., and Van Vactor D. Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron 34 (2002) 27-38
    • (2002) Neuron , vol.34 , pp. 27-38
    • Kaufmann, N.1    DeProto, J.2    Ranjan, R.3    Wan, H.4    Van Vactor, D.5
  • 26
    • 0142242179 scopus 로고    scopus 로고
    • Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    • Ko J., Na M., Kim S., Lee J.R., and Kim E. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. J. Biol. Chem. 278 (2003) 42377-42385
    • (2003) J. Biol. Chem. , vol.278 , pp. 42377-42385
    • Ko, J.1    Na, M.2    Kim, S.3    Lee, J.R.4    Kim, E.5
  • 27
    • 32544447532 scopus 로고    scopus 로고
    • Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1
    • Ko J., Yoon C., Piccoli G., Chung H.S., Kim K., Lee J.R., Lee H.W., Kim H., Sala C., and Kim E. Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1. J. Neurosci. 26 (2006) 963-970
    • (2006) J. Neurosci. , vol.26 , pp. 963-970
    • Ko, J.1    Yoon, C.2    Piccoli, G.3    Chung, H.S.4    Kim, K.5    Lee, J.R.6    Lee, H.W.7    Kim, H.8    Sala, C.9    Kim, E.10
  • 29
    • 23944515810 scopus 로고    scopus 로고
    • Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide
    • Lu J., Li H., Wang Y., Südhof T.C., and Rizo J. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. J. Mol. Biol. 352 (2005) 455-466
    • (2005) J. Mol. Biol. , vol.352 , pp. 455-466
    • Lu, J.1    Li, H.2    Wang, Y.3    Südhof, T.C.4    Rizo, J.5
  • 30
    • 27844499290 scopus 로고    scopus 로고
    • Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release
    • Maximov A., and Südhof T.C. Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron 48 (2005) 547-554
    • (2005) Neuron , vol.48 , pp. 547-554
    • Maximov, A.1    Südhof, T.C.2
  • 31
    • 33847352925 scopus 로고    scopus 로고
    • Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation
    • Maximov A., Pang Z.P., Tervo D.G., and Südhof T.C. Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J. Neurosci. Methods 161 (2007) 75-87
    • (2007) J. Neurosci. Methods , vol.161 , pp. 75-87
    • Maximov, A.1    Pang, Z.P.2    Tervo, D.G.3    Südhof, T.C.4
  • 32
    • 0035808835 scopus 로고    scopus 로고
    • Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
    • Megias M., Emri Z., Freund T.F., and Gulyas A.I. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience 102 (2001) 527-540
    • (2001) Neuroscience , vol.102 , pp. 527-540
    • Megias, M.1    Emri, Z.2    Freund, T.F.3    Gulyas, A.I.4
  • 33
    • 0036221752 scopus 로고    scopus 로고
    • Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport
    • Monier S., Jollivet F., Janoueix-Lerosey I., Johannes L., and Goud B. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Traffic 3 (2002) 289-297
    • (2002) Traffic , vol.3 , pp. 289-297
    • Monier, S.1    Jollivet, F.2    Janoueix-Lerosey, I.3    Johannes, L.4    Goud, B.5
  • 35
    • 0036022070 scopus 로고    scopus 로고
    • Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma
    • Nakata T., Yokota T., Emi M., and Minami S. Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes Chromosomes Cancer 35 (2002) 30-37
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 30-37
    • Nakata, T.1    Yokota, T.2    Emi, M.3    Minami, S.4
  • 36
    • 21844479018 scopus 로고    scopus 로고
    • ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy
    • Ohara-Imaizumi M., Ohtsuka T., Matsushima S., Akimoto Y., Nishiwaki C., Nakamichi Y., Kikuta T., Nagai S., Kawakami H., Watanabe T., and Nagamatsu S. ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Mol. Biol. Cell 16 (2005) 3289-3300
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3289-3300
    • Ohara-Imaizumi, M.1    Ohtsuka, T.2    Matsushima, S.3    Akimoto, Y.4    Nishiwaki, C.5    Nakamichi, Y.6    Kikuta, T.7    Nagai, S.8    Kawakami, H.9    Watanabe, T.10    Nagamatsu, S.11
  • 38
    • 33845900184 scopus 로고    scopus 로고
    • Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses
    • Pang Z.P., Melicoff E., Padgett D., Liu Y., Teich A.F., Dickey B.F., Lin W., Adachi R., and Südhof T.C. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J. Neurosci. 26 (2006) 13493-13504
    • (2006) J. Neurosci. , vol.26 , pp. 13493-13504
    • Pang, Z.P.1    Melicoff, E.2    Padgett, D.3    Liu, Y.4    Teich, A.F.5    Dickey, B.F.6    Lin, W.7    Adachi, R.8    Südhof, T.C.9
  • 40
  • 42
    • 0033349884 scopus 로고    scopus 로고
    • UNC-13 is required for synaptic vesicle fusion in C. elegans
    • Richmond J.E., Davis W.S., and Jorgensen E.M. UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat. Neurosci. 2 (1999) 959-964
    • (1999) Nat. Neurosci. , vol.2 , pp. 959-964
    • Richmond, J.E.1    Davis, W.S.2    Jorgensen, E.M.3
  • 44
    • 0030175394 scopus 로고    scopus 로고
    • Definition of the readily releasable pool of vesicles at hippocampal synapses
    • Rosenmund C., and Stevens C.F. Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16 (1996) 1197-1207
    • (1996) Neuron , vol.16 , pp. 1197-1207
    • Rosenmund, C.1    Stevens, C.F.2
  • 45
    • 0037204063 scopus 로고    scopus 로고
    • Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
    • Rosenmund C., Sigler A., Augustin I., Reim K., Brose N., and Rhee J.S. Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron 33 (2002) 411-424
    • (2002) Neuron , vol.33 , pp. 411-424
    • Rosenmund, C.1    Sigler, A.2    Augustin, I.3    Reim, K.4    Brose, N.5    Rhee, J.S.6
  • 47
    • 33748940272 scopus 로고    scopus 로고
    • Molecular organization of the presynaptic active zone
    • Schoch S., and Gundelfinger E.D. Molecular organization of the presynaptic active zone. Cell Tissue Res. 326 (2006) 379-391
    • (2006) Cell Tissue Res. , vol.326 , pp. 379-391
    • Schoch, S.1    Gundelfinger, E.D.2
  • 50
    • 0032546658 scopus 로고    scopus 로고
    • Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins
    • Serra-Pages C., Medley Q.G., Tang M., Hart A., and Streuli M. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 273 (1998) 15611-15620
    • (1998) J. Biol. Chem. , vol.273 , pp. 15611-15620
    • Serra-Pages, C.1    Medley, Q.G.2    Tang, M.3    Hart, A.4    Streuli, M.5
  • 52
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • Südhof T.C. The synaptic vesicle cycle. Annu. Rev. Neurosci. 27 (2004) 509-547
    • (2004) Annu. Rev. Neurosci. , vol.27 , pp. 509-547
    • Südhof, T.C.1
  • 53
    • 1642499114 scopus 로고    scopus 로고
    • Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
    • Takao-Rikitsu E., Mochida S., Inoue E., Deguchi-Tawarada M., Inoue M., Ohtsuka T., and Takai Y. Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. J. Cell Biol. 164 (2004) 301-311
    • (2004) J. Cell Biol. , vol.164 , pp. 301-311
    • Takao-Rikitsu, E.1    Mochida, S.2    Inoue, E.3    Deguchi-Tawarada, M.4    Inoue, M.5    Ohtsuka, T.6    Takai, Y.7
  • 54
    • 0037172972 scopus 로고    scopus 로고
    • Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
    • Varoqueaux F., Sigler A., Rhee J.S., Brose N., Enk C., Reim K., and Rosenmund C. Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc. Natl. Acad. Sci. USA 99 (2002) 9037-9042
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9037-9042
    • Varoqueaux, F.1    Sigler, A.2    Rhee, J.S.3    Brose, N.4    Enk, C.5    Reim, K.6    Rosenmund, C.7
  • 55
    • 33644870049 scopus 로고    scopus 로고
    • Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    • Wagh D.A., Rasse T.M., Asan E., Hofbauer A., Schwenkert I., Durrbeck H., Buchner S., Dabauvalle M.C., Schmidt M., Qin G., et al. Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron 49 (2006) 833-844
    • (2006) Neuron , vol.49 , pp. 833-844
    • Wagh, D.A.1    Rasse, T.M.2    Asan, E.3    Hofbauer, A.4    Schwenkert, I.5    Durrbeck, H.6    Buchner, S.7    Dabauvalle, M.C.8    Schmidt, M.9    Qin, G.10
  • 56
    • 0037195108 scopus 로고    scopus 로고
    • A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
    • Wang Y., Liu X., Biederer T., and Südhof T.C. A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Proc. Natl. Acad. Sci. USA 99 (2002) 14464-14469
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14464-14469
    • Wang, Y.1    Liu, X.2    Biederer, T.3    Südhof, T.C.4
  • 57
    • 0033598333 scopus 로고    scopus 로고
    • The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
    • Zhen M., and Jin Y. The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans. Nature 401 (1999) 371-375
    • (1999) Nature , vol.401 , pp. 371-375
    • Zhen, M.1    Jin, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.