β phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

Cell

Volumn 108, Issue 1, 2002, Pages 121-133

  Rhee, Jeong Seop ^a   Betz, Andrea ^b   Pyott, Sonja ^a   Reim, Kerstin ^b,c   Varoqueaux, Frederique ^b,c   Augustin, Iris ^b,c   Hesse, Dörte ^c   Südhof, Thomas C ^d   Takahashi, Masami ^e   Rosenmund, Christian ^a   Brose, Nils ^b,c  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b Abteilung Molekulare Neurobiologie   (Germany)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; MUTANT PROTEIN; PHORBOL ESTER; PRESYNAPTIC RECEPTOR; PROTEIN DERIVATIVE; PROTEIN KINASE C; PROTEIN MUNC13S; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA MODIFICATION; EXPERIMENTAL MODEL; HIPPOCAMPUS; MOUSE; NERVE CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN VARIANT; REGULATORY MECHANISM; SECOND MESSENGER; SURVIVAL; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 18244389735     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00635-3     Document Type: Article

References (48)

1. Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells
2. Differential expression of two novel Munc13 proteins in rat brain
3. Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
4. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice
5. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in culture
6. Direct interaction of the rat unc-13 homologue Munc13-1 with the N-terminus of syntaxin
7. Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release
8. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
9. 2-domain proteins
10. Regulation of transmitter release by Unc-13 and its homologues
11. Presynaptic PKC substrate B-50 (GAP-43) and neurotransmitter release: Studies with permeated synaptosomes
12. Export of protein from the endoplasmatic reticulum is regulated by a diacylglycerol/phorbol ester binding protein
13. Phorbol ester effects at hippocampal synapses act independently of the gamma isoform of PKC
14. Learning to modulate neurotransmitter release: Themes and variations in synaptic plasticity
15. The probability of transmitter release at a mammalian central synapse
16. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC
17. Re-evaluation of phorbol ester-induced potentiation of transmitter release from mossy fibre terminals of the mouse hippocampus
18. Presynaptic mechanism for phorbol ester-induced synaptic potentiation
19. Two distinct mechanisms underlie the stimulation of neurotransmitter release by phorbol esters in clonal rat pheochromocytoma PC12 cells
20. Erythropoietin inhibits calcium-induced neurotransmitter release from clonal neuronal cells
21. Pharmacology of the receptors for the phorbol ester tumor promoters: Multiple receptors with different biochemical properties
22. qα and EGL-8 PLCβ: DAG binding to UNC-13 is required to stimulate acetylcholine release
23. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
24. Protein kinase C: A physiological mediator of enhanced transmitter output
25. Long-term potentiation - A decade of progress?
26. qα pathway in C. elegans
27. Potentiation of transmitter release by protein kinase C in goldfish retinal bipolar cells
28. Presynaptic and postsynaptic mechanisms of long-term potentiation
29. Serotonin inhibition of synaptic transmission: GOA-1 decreases the abundance of UNC-13 at release sites
30. Phosphorylation regulates spontaneous and evoked transmitter release at a giant terminal in the rat auditory brainstem
31. Release probability modulates short-term plasticity at a rat giant terminal
32. Phorbol esters enhance synaptic transmission by a presynaptic, calcium-dependent mechanism in rat hippocampus
33. Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings
34. An open form of syntaxin bypasses the requirement for unc-13 in vesicle priming
35. Definition of the readily releasable pool of vesicles at hippocampal synapses
36. Nonuniform probability of glutamate release at a hippocampal synapse
37. Synaptic NMDA receptor channels have a low open probability
38. Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
39. Quantitative relationship between transmitter release and calcium current at the calyx of Held synapse
40. Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held
41. Phosphorylation of 25-kDa synaptosome-associated protein. Possible involvement in protein kinase C-mediated regulation of neurotransmitter release
42. Cloning of a novel gene in the human kidney homologous to rat munc13s: Its potential role in diabetic nephropathy
43. Estimates for the pool size of releasable quanta at a single central synapse and for the time required to refill the pool
44. Regulation of the readily releasable vesicle pool by protein kinase C
45. 2+-dependent steps leading to secretion in chromaffin cells from mouse adrenal slices
46. Phorbol esters potentiate evoked and spontaneous release by different presynaptic mechanisms
47. Protein kinase C potentiates transmitter release from the chick ciliary presynaptic terminal by increasing the exocytotic fusion probability
48. Two components of transmitter release from the chick ciliary presynaptic terminal and their regulation by protein kinase C