Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Nature

Volumn 400, Issue 6743, 1999, Pages 457-461

  Augustin, Iris ^a   Rosenmund, Christian ^b   Südhof, Thomas C ^c   Brose, Nils ^a  

^a Max Planck Institute of Multidisciplinary Sciences   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN RECEPTOR; GLUTAMIC ACID; NEUROTRANSMITTER;

ARTICLE; ELECTROPHYSIOLOGY; MOUSE; NERVE POTENTIAL; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SYNAPSE VESICLE; TISSUE DISTRIBUTION;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE FUSION; MICE; NERVE TISSUE PROTEINS; NEURONS; RECEPTORS, N-METHYL-D-ASPARTATE; SEQUENCE DELETION; SPIDER VENOMS; SYNAPSES; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 0033615054     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/22768     Document Type: Article

References (17)

1. Südhof, T. C. The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375, 645-653 (1995).
2. Zucker, R. S. Exocytosis: a molecular and physiological perspective. Neuron 17, 1049-1055 (1996).
3. 2-domain proteins. J. Biol. Chem. 270, 25273-25280 (1995).
4. Betz, A. et al. Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron 21, 123-136 (1998).
5. Stevens, C. F. & Tsujimoto, T. Estimates for the pool size of releasable quanta at a single central synapse and for the time required to fill a pool. Proc. Natl. Acad. Sci. USA 92, 846-894 (1995).
6. Rosenmund, C. & Stevens, C. F. Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16, 1197-1207 (1996).
7. Zucker, R. S. Changes in the statistics of transmitter release during facilitation. J. Physiol. 229, 787-810 (1973).
8. Zucker, R. S. Short-term synaptic plasticity. Anna. Rev. Neurosci. 12, 13-31 (1989).
9. Rosenmund, C., Clements, J. D. & Westbrook, G. L. Nonuniform probability of glutamate release at a hippocampal synapse. Science 262, 754-757 (1993).
10. Hessler, N. A., Shirke, A. M. & Malinow, R. The probability of transmitter release at a mammalian synapse. Nature 366, 569-572 (1993).
11. Rosenmund, C., Feltz, A. & Westbrook, G. L. Synaptic NMDA receptor channels have a low open probability. J. Neurosci. 15, 2788-2795 (1995).
12. 2+-sensor for transmitter release at a central synapse. Cell 79, 717-727 (1994).
13. Krasnoperov, V. G. et al. α-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron 18, 925-937 (1997).
14. Lelianova, V. G. et al. α-Latrotoxin receptor, latrophilin, is a novel member of the secretin family of G-protein coupled receptors. J. Biol. Chem. 272, 21504-21508 (1997).
15. Martin, T. F. Mechanisms of protein secretion in endocrine and exocrine cells. Vitamins Hormones 54, 207-226 (1998).
16. Bekkers, J. M. & Stevens, C. F. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in culture. Proc Natl Acad. Sci. USA 88, 7834-7838 (1991).
17. Boyer, C., Schikorski, T. & Stevens, C. F. Comparison of hippocampal dendritic spines in culture and in brain. J. Neurosci. 18, 5294-5300 (1998).