Synaptotagmin-2 is essential for survival and contributes to Ca 2+ triggering of neurotransmitter release in central and neuromuscular synapses

Journal of Neuroscience

Volumn 26, Issue 52, 2006, Pages 13493-13504

  Pang, Zhiping P ^a   Melicoff, Ernestina ^c   Padgett, Daniel ^a   Liu, Yun ^a   Teich, Andrew F ^c   Dickey, Burton F ^c   Lin, Weichun ^a   Adachi, Roberto ^c   Südhof, Thomas C ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Asynchronous release; Endplate; Neuromuscular junction; Striatum; Synapse; Synaptotagmin

Indexed keywords

BETA GALACTOSIDASE; CALCIUM ION; SYNAPTOTAGMIN II;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE MUTATION; GENE SEQUENCE; KINETICS; MALE; MORTALITY; MOTOR DYSFUNCTION; MOUSE; MOUSE STRAIN; NERVE CELL PLASTICITY; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; SYNAPTIC TRANSMISSION;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTER AGENTS; PROTEIN ISOFORMS; SYNAPSES; SYNAPTIC TRANSMISSION; SYNAPTOTAGMIN II;

EID: 33845900184     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3519-06.2006     Document Type: Article

References (33)

1. Atluri PP, Regehr (1998) Delayed release of neurotransmitter from cerebellar granule cells. J Neurosci 18:8214-8227.
2. 2+-triggered exocytosis of lysosomes in mast cells. J Exp Med 189:1649-1658.
3. Barrett EF, Stevens CF (1972) The kinetics of transmitter release at the frog neuromuscular junction. J Physiol (Lond) 227:691-708.
4. Buffelli M, Burgess RW, Feng G, Lobe CG, Lichtman JW, Sanes JR (2003) Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature 424:430-434.
5. Cruz LJ, Gray WR, Olivera BM, Zeikus RD, Kerr L, Yoshikami D, Moczydlowski E (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem 260:9280-9288.
6. Cummings DD, Wilcox KS, Dichter MA (1996) Calcium-dependent paired-pulse facilitation of miniature EPSC frequency accompanies depression of EPSCs at hippocampal synapses in culture. J Neurosci 16:5312-5323.
7. Dirks W, Wirth M, Hauser H (1993) Dicistronic transcription units for gene expression in mammalian cells. Gene 128:247-249.
8. Fernandez-Chacon R, Konigstorfer A, Gerber SH, Garcia J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Südhof TC (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature 410:41-49.
9. Geppert M, Archer III BT, Südhof TC (1991) Synaptotagmin II. A novel differentially distributed form of synaptotagmin. J Biol Chem 266:13548-13552.
10. 2+ sensor for transmitter release at a central synapse. Cell 79:717-727.
11. Goda Y, Stevens CF (1994) Two components of transmitter release at a central synapse. Proc Natl Acad Sci USA 91:12942-12946.
12. Goldhamer DJ, Faerman A, Shani M, Emerson Jr CP (1992) Regulatory elements that control the lineage-specific expression of myoD. Science 256:538-542.
13. Hagler DJ, Goda Y (2001) Properties of synchronous and asynchronous release during pulse train depression in cultured hippocampal neurons. J Neurophysiol 85:2324-2334.
14. 2+ regulators in neurotransmitter release. Neuron 24:1003-1016.
15. Katz B, Miledi R (1967) The timing of calcium action during neuromuscular transmission. J Physiol (Lond) 189:535-544.
16. Katz B, Miledi R (1968) The role of calcium in neuromuscular facilitation. J Physiol (Lond) 195:481-492.
17. Kerr AM, Reisinger E, Fakler B, Jonas PM (2006) Synaptotagmin 1 is not required for fast, synchronous synaptic transmission at inhibitory synapses between parvalbumin-expressing basket cells and granule cells in hippocampus. Soc Neurosci Abstr 337.2/I15.
18. Liley AW (1956) The quantal components of the mammalian end-plate potential. J Physiol (Lond) 133:571-587.
19. Lu T, Trussell LO (2000) Inhibitory transmission mediated by asynchronous transmitter release. Neuron 26:683-694.
20. Mao L, Wang JQ (2001) Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons. Mol Brain Res 86:125-137.
21. Marqueze B, Boudier JA, Mizuta M, Inagaki N, Seino S, Seagar M (1995) Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat. J Neurosci 15:4906-4917.
22. Maximov A, Südhof TC (2005) Autonomous function of synaptotagmin-1 in triggering synchronous release independent of asynchronous release. Neuron 48:547-554.
23. Nagy G, Kim JH, Pang ZP, Matti U, Rettig J, Südhof TC, Sorensen JB (2006) Different effects on fast exocytosis induced by synaptotagmin-1 and 2 isoforms and abundance, but not by phosphorylation. J Neurosci 26:632-643.
24. Nishiki T, Augustine GJ (2004) Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons. J Neurosci 24:6127-6132.
25. Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (2002) Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. J Cell Biol 158:577-590.
26. Otsu Y, Shahrezaei V, Li B, Raymond LA, Delaney KR, Murphy TH (2004) Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses. J Neurosci 24:420-433.
27. 2+-triggered neurotransmitter release. EMBO J 25:2039-2050.
28. Perin MS, Fried VA, Mignery GA, Jahn R, Südhof TC (1990) Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345:260-263.
29. Stevens CF, Sullivan JM (2003) The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmission. Neuron 39:299-308.
30. Südhof TC (2002) Synaptotagmins: why so many? J Biol Chem 277:7629-7632.
31. 2+ affinities. EMBO J 21:270-280.
32. Ullrich B, Li C, Zhang JZ, McMahon H, Anderson RG, Geppert M, Südhof TC (1994) Functional properties of multiple synaptotagmins in brain. Neuron 13:1281-1291.
33. Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64:355-405.