Centrosome overduplication, chromosomal instability, and human papillomavirus oncoproteins

Environmental and Molecular Mutagenesis

Volumn 50, Issue 8, 2009, Pages 741-747

  Duensing, Anette ^a   Spardy, Nicole ^a   Chatterjee, Payel ^a   Zheng, Leon ^a   Parry, Joshua ^a   Cuevas, Rolando ^a   Korzeniewski, Nina ^a   Duensing, Stefan ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Cancer; Centrosome; Chromosomal instability; HPV

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; ONCOPROTEIN; POLO LIKE KINASE; PROTEIN E6; PROTEIN E7; PROTEIN PLK4; UNCLASSIFIED DRUG; VIRUS PROTEIN;

CARCINOGENESIS; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE OVEREXPRESSION; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; MOLECULAR MECHANICS; NEOPLASM; NONHUMAN; REVIEW;

CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATIONS; HUMANS; PAPILLOMAVIRIDAE; VIRAL PROTEINS;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16;

EID: 70349905411     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20478     Document Type: Review

References (57)

1. Balsitis SJ, Sage J, Duensing S, Munger K, Jacks T, Lambert PF. 2003. Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRB-independent effects of E7 in vivo. Mol Cell Biol 23:9094-9103. (Pubitemid 37499799)
2. Crum CP, Ikenberg H, Richart RM, Gissman L. 1984. Human papillomavirus type 16 and early cervical neoplasia. N Engl J Med 310:880-883. (Pubitemid 14173180)
3. De Luca A, Mangiacasale R, Severino A, Malquori L, Baldi A, Palena A, Mileo AM, Lavia P, Paggi MG. 2003. E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner. Cancer Res 63:1430-1437. (Pubitemid 36348727)
4. DiMaio D, Liao JB. 2006. Human papillomaviruses and cervical cancer. Adv Virus Res 66:125-159.
5. Duensing S. 2005. A tentative classification of centrosome abnormalities in cancer. Cell Biol Int 29:352-359. (Pubitemid 40981993)
6. Duensing S, Munger K. 2001. Centrosome abnormalities, genomic instability and carcinogenic progression. Biochim Biophys Acta 1471:M81-M88. (Pubitemid 32146548)
7. Duensing S, Munger K. 2002a. Human papillomaviruses and centrosome duplication errors: Modeling the origins of genomic instability. Oncogene 21:6241-6248.
8. Duensing S, Munger K. 2002b. The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res 62:7075-7082. (Pubitemid 35424103)
9. Duensing S, Münger K. 2003. Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members. J Virol 77:12331-12335. (Pubitemid 37339885)
10. Duensing S, Lee LY, Duensing A, Basile J, Piboonniyom S, Gonzalez S, Crum CP, Munger K. 2000. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci USA 97:10002-10007. (Pubitemid 30680845)
11. Duensing S, Duensing A, Crum CP, Munger K. 2001a. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res 61:2356-2360. (Pubitemid 32685804)
12. Duensing S, Duensing A, Flores ER, Do A, Lambert PF, Munger K. 2001b. Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes. J Virol 75:7712-7716. (Pubitemid 32738029)
13. Duensing S, Duensing A, Lee DC, Edwards KM, Piboonniyom S, Manuel E, Skaltsounis L, Meijer L, Munger K. 2004. Cyclin-dependent kinase inhibitor indirubin-30-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies. Oncogene 23:8206-8215. (Pubitemid 39531832)
14. Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S. 2006. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene 25:2943-2949. (Pubitemid 43739245)
15. Duensing A, Liu Y, Spardy N, Bartoli K, Tseng M, Kwon JA, Teng X, Duensing S. 2007a. RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication. Oncogene 26:215-223. (Pubitemid 46095732)
16. Duensing A, Liu Y, Perdreau SA, Kleylein-Sohn J, Nigg EA, Duensing S. 2007b. Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates. Oncogene 26:6280-6288. (Pubitemid 47462107)
17. Duensing A, Chin A, Wang L, Kuan SF, Duensing S. 2008. Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms. Virology 372:157-164. (Pubitemid 351215468)
18. Dyson N, Howley PM, Munger K, Harlow E. 1989. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937. (Pubitemid 19066153)
19. Fukasawa K. 2007. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 7:911-924. (Pubitemid 350165854)
20. Funk JO, Waga S, Harry JB, Espling E, Stillman B, Galloway DA. 1997. Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev 11:2090-2100. (Pubitemid 27369103)
21. Gardiol D, Kuhne C, Glaunsinger B, Lee SS, Javier R, Banks L. 1999. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene 18:5487-5496. (Pubitemid 29481495)
22. Gonzalez SL, Stremlau M, He X, Basile J, Munger K. 2001. Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J Virol 75:7583-7591. (Pubitemid 32738016)
23. Guarguaglini G, Duncan PI, Stierhof YD, Holmstrom T, Duensing S, Nigg EA. 2005. The forkhead-associated domain protein Cep170 interacts with polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell 16:1095-1107. (Pubitemid 40349548)
24. Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA. 2005. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol 7:1140-1146.
25. Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. 1999. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283:851-854. (Pubitemid 129501126)
26. Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K. 2007. Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J Virol 81:9737-9747. (Pubitemid 350067678)
27. Jones DL, Alani RM, Munger K. 1997. The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev 11:2101-2111. (Pubitemid 27369104)
28. Kashyap V, Das BC. 1998. DNA aneuploidy and infection of human papillomavirus type 16 in preneoplastic lesions of the uterine cervix: Correlation with progression to malignancy. Cancer Lett 123:47-52. (Pubitemid 28046208)
29. Kessis TD, Connolly DC, Hedrick L, Cho KR. 1996. Expression of HPV16 E6 or E7 increases integration of foreign DNA. Oncogene 13:427-431. (Pubitemid 26334876)
30. Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA. 2007. Plk4-induced centriole biogenesis in human cells. Dev Cell 13:190-202. (Pubitemid 47163610)
31. Klingelhutz AJ, Foster SA, McDougall JK. 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82. (Pubitemid 26076241)
32. Lacey KR, Jackson PK, Stearns T. 1999. Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci USA 96:2817-2822. (Pubitemid 29148801)
33. Lee SS, Weiss RS, Javier RT. 1997. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci USA 94:6670-6675. (Pubitemid 27281922)
34. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL. 2002. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA 99:1978-1983. (Pubitemid 34169000)
35. Liu X, Han S, Baluda MA, Park NH. 1997. HPV-16 oncogenes E6 and E7 are mutagenic in normal human oral keratinocytes. Oncogene 14:2347-2353. (Pubitemid 27260727)
36. Loncarek J, Hergert P, Magidson V, Khodjakov A. 2008. Control of daughter centriole formation by the pericentriolar material. Nat Cell Biol 10:322-328. (Pubitemid 351331019)
37. Longworth MS, Laimins LA. 2004. Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68:362-372.
38. Matsumoto Y, Hayashi K, Nishida E. 1999. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. Curr Biol 9:429-432. (Pubitemid 29205787)
39. McLaughlin-Drubin ME, Munger K. 2008. Viruses associated with human cancer. Biochim Biophys Acta 1782:127-150.
40. McLaughlin-Drubin ME, Huh KW, Munger K. 2008. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J Virol 82:8695-8705.
41. Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA. 1999. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol 1:88-93. (Pubitemid 129501949)
42. Munger K, Howley PM. 2002. Human papillomavirus immortalization and transformation functions. Virus Res 89:213-228. (Pubitemid 35351540)
43. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJF, Meijer CJLM. 2003. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518-527. (Pubitemid 36159887)
44. Nguyen CL, Munger K. 2008. Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes. Virology 380:21-25.
45. Nguyen CL, Eichwald C, Nibert ML, Munger K. 2007. Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. J Virol 81:13533-13543. (Pubitemid 350247847)
46. Nigg EA. 2002. Centrosome aberrations: Cause or consequence of cancer progression? Nature Rev Cancer 2:1-11.
47. Piel M, Meyer P, Khodjakov A, Rieder CL, Bornens M. 2000. The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J Cell Biol 149:317-330. (Pubitemid 30227150)
48. Pihan GA, Purohit A, Wallace J, Knecht H, Woda B, Quesenberry P, Doxsey SJ. 1998. Centrosome defects and genetic instability in malignant tumors. Cancer Res 58:3974-3985. (Pubitemid 28405657)
49. Riley RR, Duensing S, Brake T, Munger K, Lambert PF, Arbeit JM. 2003. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res 63:4862-4871. (Pubitemid 37022618)
50. Salisbury JL, Whitehead CM, Lingle WL, Barrett SL. 1999. Centrosomes and cancer. Biol Cell 91:451-460.
51. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136. (Pubitemid 120035062)
52. Skyldberg B, Fujioka K, Hellstrom AC, Sylven L, Moberger B, Auer G. 2001. Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions. Mod Pathol 14:279-284. (Pubitemid 32298912)
53. Spardy N, Duensing A, Charles D, Haines N, Nakahara T, Lambert PF, Duensing S. 2007. The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol 81:13265-13270. (Pubitemid 350156966)
54. Strnad P, Leidel S, Vinogradova T, Euteneuer U, Khodjakov A, Gonczy P. 2007. Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. Dev Cell 13:203-213. (Pubitemid 47163611)
55. Veldman T, Horikawa I, Barrett JC, Schlegel R. 2001. Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol 75:4467-4472. (Pubitemid 32410165)
56. Zerfass-Thome K, Zwerschke W, Mannhardt B, Tindle R, Botz JW, Jansen-Durr P. 1996. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323-2330. (Pubitemid 27026015)
57. zur Hausen H. 2002. Papillomaviruses and cancer: From basic studies to clinical application. Nat Rev Cancer 2:342-350.