Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7712-7716

  Duensing, S ^a   Duensing, A ^a   Flores, E R ^a   Do, A ^a   Lambert, P F ^a   Munger K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN;

ARTICLE; CELL CULTURE; CENTROSOME; EPISOME; HUMAN; HUMAN CELL; KERATINOCYTE; MITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS INFECTION; VIRUS TRANSCRIPTION; WART VIRUS;

CELLS, CULTURED; CENTROMERE; CHROMOSOME FRAGILITY; HUMANS; KERATINOCYTES; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PLASMIDS; TUMOR VIRUS INFECTIONS;

EID: 0034910012     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7712-7716.2001     Document Type: Article

References (21)

1. Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS
2. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway
3. Human papillomavirus type 16 and early cervical neoplasia
4. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle
5. Centrosome abnormalities, genomic instability and carcinogenic progression
6. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis in an early event in the evolving malignant phenotype
7. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
8. Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line
9. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle
10. Definition of precursors
11. Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene
12. Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix
13. Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells
14. Expression of HPV16 E6 or E7 increases integration of foreign DNA
15. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
16. Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint
17. Human papillomavirus type 31 oncoprotein E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes
18. The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints
19. The centrosome
20. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins
21. Viruses in human cancers