Protective effects of topiramate against hyperoxic brain injury in the developing brain

Neuropediatrics

Volumn 40, Issue 1, 2009, Pages 22-27

  Kurul, S H ^a   Yi, U ^a   Kumral, A ^a   Tuyan, K ^a   Cilaker, S ^a   Kolatan, E ^a   Ylmaz, O ^a   Genc S ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

apoptosis; brain; hyperoxia; newborn; rat; topiramate

Indexed keywords

TOPIRAMATE; DNA; DRUG DERIVATIVE; FRUCTOSE; HISTONE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN INJURY; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; HIPPOCAMPUS; HISTOPATHOLOGY; HYPEROXIA; NERVE CELL NECROSIS; NERVE DEGENERATION; NEURODEGENERATION WITH BRAIN IRON ACCUMULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; WHITE MATTER; ANALYSIS OF VARIANCE; ANIMAL; CELL DEATH; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY; NEWBORN; NICK END LABELING; PARIETAL LOBE; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FRUCTOSE; HIPPOCAMPUS; HISTONES; HYPEROXIA; IN SITU NICK-END LABELING; NEUROPROTECTIVE AGENTS; PARIETAL LOBE; RATS; RATS, WISTAR;

EID: 70349903402     PISSN: 0174304X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1224101     Document Type: Article

References (35)

1. Arkovitz MS, Szabo C, Garcia VF, etal. Differential effects of hyperoxia on the inducible and constitutive isoforms of nitric oxide synthase in the lung. Shock 1997 7 345-350
2. Cha HB, Silveria CD, Liu X, etal. Effect of topiramate following recurrent and prolonged seizures during early development. Epi Res 2002 51 217-232
3. Chen X, Bao G, Hua Y, etal. The effects of topiramate on caspase-3 expression in hippocampus of basolateral amygdala (BLA) electrical kindled epilepsy rat. J Mol Neurosci 2009 epub ahead of print
4. Dobbing J, Sands J, Gratrix CA. Cell size and cell number: a reconsideration of organ growth and catch-up potential. Proc Nutr Soc 1979 38 99A
5. Felderhoff-Mueser U, Bittigau P, Sifringer M, etal. Oxygen causes cell death in the developing brain. Neurobiol Dis 2004 17 273-282
6. Felderhoff-Mueser U, Sifringer M, Polley O, etal. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol 2005 57 50-59
7. Follett PL, Deng W, Dai W, etal. Glutamate receptor-mediated oligodendrocyte toxity in periventricular leukomalacia: a protective role for topiramate. J Neurosci 2004 24 4412-4420
8. Gerdin E, Tyden O, Eriksson UJ. The development of antioxidant enzymatic defense in the perinatal rat lung: activities of superoxide dismutase, glutathione peroxidase, and catalase. Pediatr Res 1985 19 687-691
9. Gerstner B, DeSilva TM, Genz K, etal. Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci 2008 28 1236-1245
10. Gibbs JW, Sombati S, DeLorenzo RJ, etal. Cellular actions of topiramate: blockade of kainate-evoked inward currents incultured hippocampal neurons. Epilepsia 2000 41 10-16
11. Glier C, Dzietko M, Bittigau P, etal. Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 2004 187 403-409
12. Haugvicova R, Kubova? H, Skutova M, etal. Anticonvulsant action of topiramate against motor seizures in developing rats. Epilepsia 2000 41 1235-1240
13. Hintz SR, Kendrick DE, Vohr BR, etal National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months corrected age among infants of less than 25 weeks gestational age born in 1993 1999. Pediatrics 2005 115 1645-1651
14. Hu X, Qiu J, Grafe MR, etal. Bcl-2 family members make different contributions to cell death in hypoxia and/or hyperoxia in rat cerebral cortex. Int J Dev Neurosci 2003 21 371-377
15. Ikonomidou C, Bosch F, Miksa M, etal. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999 283 70-74 (Pubitemid 29044848)
16. Ishikawa Y, Satoh T, Enokido Y, etal. Generation of reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen induced apoptosis of embryonic hippocampal neurons in culture. Brain Res 1999 824 71-80
17. Kockelmann E, Elger CE, Helmstaedter C. Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of topiramate in epilepsy patients. Epilepsy Res 2003 54 171-178
18. Koch JD, Miles DK, Gilley JA, etal. Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury. J Cereb Blood Flow Metab 2008 28 1294-1306
19. Liu Y, Barks JD, Xu G, etal. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 2004 35 1460-1465
20. Niebauer M, Gruenthal M. Topiramate reduces neuronal injury after experimental status epilepticus. Brain Res 1999 837 263-269
21. Noh MR, Kim SK, Sun W, etal. Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats. Exp Neurol 2007 203 5-7
22. Park HJ, Kim HJ, Ra J, etal. Protective effect of topiramate on kainic acid-induced cell death in mice hippocampus. Epilepsia 2008 49 163-167
23. Perucca E. A pharmacological and clinical review on topiramate, a new antiepileptic drug. Parmacol Res 1997 35 241-256
24. Rosen GD, Williams AG, Capra JA, etal. The Mouse Brain. Library 2000, available from: www.mbl.org
25. Rosenfeld WE. Topiramate: a review of preclinical, pharmacokinetic, and clinical data. Clin Ther 1997 19 1294-1308
26. Schneiderman JH. Topiramate: pharmacokinetics and pharmacodynamics. Can J Neurol Sci 1998 25 3-5
27. Schubert S, Brandl U, Brodhun M, etal. Neuroprotective effects of topiramate after hypoxia-ischemia in newborn piglets. Brain Res 2005 1058 129-136
28. Sennlaub F, Courtois Y, Goureau O. Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy. J Clin Invest 2001 107 717-725
29. Sfaello I, Baud O, Arzimanoglou A, etal. Topiramate prevents excitotoxic damage in the newborn rodent brain. Neurobiol Dis 2005 20 837-848
30. Shank RP, Gardocki JF, Vaught JL, etal. Topiramate: preclinical evaluation of structurally novel anticonvulsant. Epilepsia 1994 35 450-460
31. Sirinyan M, Sennlaub F, Dorfman A, etal. Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject. Stroke 2006 37 2807-2815
32. Sola A, Rogido MR, Deulofeut R. Oxygen as a neonatal health hazard: call for dtente in clinical practice. Acta Paediatr 2007 96 801-812
33. White HS, Brown SD, Woodhead JH, etal. Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res 1997 28 167-179
34. Willmore LJ. Antiepileptic drugs and neuroprotection: current status and future roles. Epilepsy Behav 2005 7 25-28
35. Yis U, Kurul SH, Kumral A, etal. Hyperoxic exposure leads to cell death in the developing brain. Brain Dev 2008 30 556-562