The effects of topiramate on caspase-3 expression in hippocampus of basolateral amygdala (BLA) electrical kindled epilepsy rat

Journal of Molecular Neuroscience

Volumn 38, Issue 2, 2009, Pages 201-206

  Chen, Xuqin ^a   Bao, Guanshui ^c   Hua, Ying ^d   Li, Yan ^a   Wang, Zhedong ^a   Zhang, Xueguang ^b  

^a CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c School of Medicine   (China)

^d WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Basolateral amygdala (BLA); Caspase 3; Epilepsy; Kindling; Topiramate

Indexed keywords

CASPASE 3; MESSENGER RNA; TOPIRAMATE; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; FRUCTOSE; NEUROPROTECTIVE AGENT;

AFTERDISCHARGE; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRODE; ELECTROENCEPHALOGRAPHY; EPILEPSY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEIZURE; UPREGULATION; VIDEORECORDING; ANIMAL; CYTOLOGY; ELECTROSTIMULATION; GENETICS; KINDLING; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

AMYGDALA; ANIMALS; ANTICONVULSANTS; CASPASE 3; ELECTRIC STIMULATION; EPILEPSY; FRUCTOSE; HIPPOCAMPUS; KINDLING, NEUROLOGIC; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 69249232334     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-008-9173-4     Document Type: Article

References (37)

1. Asprodini, E. K., Rainnie, D. G., Anderson, A. C., & ShinnickGallagher, P. (1992). In vivo kindling does not alter afterhyperpolarization (AHPs) following action potential firing in vitro in basolateral amygdala neurons. Brain Research, 588, 329-334.
2. Bengzon, J., Mohapel, P., & Ekdahl, C. T. (2002). Neuronal apoptosis after brief and prolonged seizures. Progress in Brain Research, 135, 111-119.
3. Biton, V., Montouris, G. D., Ritter, F., et al. (1999). A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures. Neurology, 52, 1330-1337.
4. Cha, B. H., Silveira, D. C., Liu, X., Hu, Y., & Holmes, G. L. (2002). Effect of topiramate following recurrent and prolonged seizures during early development. Epilepsy Research, 51, 217-232.
5. DeLorenzo, R. J., Morris, T. A., Blair, R. E., Wallace, M., & Razvi, B. (2002). Topiramate is both neuroprotective and antiepileptogenic in the pilocarpine model of status epilepticus. Epilepsia, 43 (Suppl 7), S15.
6. Edmonds Jr., H. L., Jiang, Y. D., Zhang, P. Y., & Shank, R. (2001). Topiramate as a neuroprotectant in a rat model of global ischemia-induced degeneration. Life Science, 69, 2265-2277.
7. Ekdahl, C. T., Mohapel, P., Weber, E., Bahr, B., Blomgren, K., & Lindvall, O. (2002). Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus. European Journal of Neuroscience, 16(8), 1463-1471.
8. Elterman, R. D., Glauser, T. A., Wyllie, E., Reife, R., Wu, S.-C., Pledger, G., Topiramate, Y. P., & Study Group (1999). A doubleblind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children. Neurology, 52, 1338-1344.
9. Faherty, C. J., Xanthoudakis, S., & Smeyne, R. J. (1999). Caspase-3dependent neuronal death in the hippocampus following kainic acid treatment. Molecular Brain Research, 70(1), 159-163.
10. Fernandes-Alnemri, T., Litwack, G., & Alnemri, E. S. (1994). CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1ßconverting enzyme. Journal of Biological Chemistry, 269, 30761-30764.
11. Frisch, C., Kudin, A. P., Elger, C. E., Kunz, W. S., & Helmstaedter, C. (2007). Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. Epilepsy Research, 73(2), 173-180.
12. Gean, P. W., Shinnick-Gallagher, P., & Anderson, A. C. (1989). Spontaneous epileptiform activity and alteration of GABA- and of NMDA- mediated neurotransmission in amygdala neurons kindled in vivo. Brain Research, 494, 177-181.
13. Gibbs 3rd, J. W., Sombati, S., DeLorenzo, R. J., & Coulter, D. A. (2000). Cellular actions of topiramate: blockade of kainateevoked inward currents in cultured hippocampal neurons. Epilepsia, 41(Suppl 1), S10-S16.
14. Glier, C., Dzietko, M., Bittigau, P., Jarosz, B., Korobowicz, E., & Ikonomidou, C. (2004). Therapeutic doses of topiramate are not toxic to the developing rat brain. Experimental Neurology, 187, 403-409.
15. Guberman, A., Neto, W., Gassmann-Mayer, C., & EPAJ-119 Study Group (2002). Low-dose topiramate in adults with treatmentresistant partial-onset seizures. Acta Neurologica Scandinavica, 106, 183-189.
16. Henshall, D. C., Chen, J., & Simon, R. P. (2000a). Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of Neurochemistry, 74(3), 1215-1223.
17. Henshall, D. C., Clark, R. S., Adelson, P. D., Chen, M., Watkins, S. C., & Simon, R. P. (2000b). Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy. Neurology, 55(2), 250-257.
18. Holmes, K. H., Keele, N. B., & Shinnick-Gallagher, P. (1996). Loss of metabotropic glutamate receptor (mGluR)-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy. Journal of Neurophysiology, 76, 1208-1212.
19. Kondratyev, A., Selby, D., & Gale, K. (2002). Status epilepticus leads to the degradation of the endogenous inhibitor of caspaseactivated DNase in rats. Neuroscience Letters, 319, 145-148.
20. Krajewska, M., Wang, H.-G., Krajewski, S., et al. (1997). Immunohistochemical analaysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Research, 57, 1605-1613.
21. Kudin, A. P., Debska-Vielhaber, G., Vielhaber, S., Elger, C. E., & Kunz, W. S. (2004). The mechanism of neuroprotection by topiramate in an animal model of epilepsy. Epilepsia, 45(12), 1478-1487.
22. Löscher, W., Ebert, U., Wahnschaffe, U., & Rundfeldt, C. (1995). Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: comparison with the basolateral amygdala and "area tempestas. Neuroscience, 66, 265-276.
23. Morimoto, K., Fahnestock, M., & Racine, R. J. (2004). Kindling and status epilepticus models of epilepsy: rewiring the brain. Progress in Neurobiology, 73(1), 1-60.
24. Nicholson, D. W., Ambereen, A., Thornberry, N. A., et al. (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43.
25. Noè, F., Pool, A. H., Nissinen, J., Gobbi, M., et al. (2008). Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain, 131(6), 1506-1515.
26. Pitkanen, A. (2004). New pharmacotherapy for epilepsy. Idrugs, 7(5), 471-477.
27. Privitera, M. D., Brodie, M. J., Mattson, R. H., Chadwick, D. W., Neto, W., Wang, S., & EPMN 105 Study Group (2003). Topiramate, carbamazepine and valproate monotherapy: doubleblind comparison in newly diagnosed epilepsy. Acta Neurologica Scandinavica, 107, 165-175.
28. Racine, R. J. (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol, 32, 281-294.
29. Rainnie, D. G., Asprodini, E. K., & Shinnick-Gallagher, P. (1992). Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala. Journal of Neurophysiology, 67, 443-454.
30. Rigoulot, M. A., Koning, E., Ferrandon, A., & Nehlig, A. (2004). Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy. Journal of Pharmacology and Experimental Therapeutics, 308(2), 787-795.
31. Sachdeo, R. C., Glauser, T. A., Ritter, F., Reife, R., Lim, P., Pledger, G., Topiramate, Y. L., & Study Group (1999). A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Neurology, 52, 1882-1887.
32. Sakurai, M., Nagata, T., Abe, K., Horinouchi, T., Itoyama, Y., & Tabayashi, K. (2003). Survival and death-promoting events after transient spinal cord ischemia in rabbits: Induction of Akt and caspase3 in motor neurons. Journal of Thoracic and Cardiovascular Surgery, 125, 370.
33. Shank, R. P., Gardocki, J. F., Streeter, A. J., & Maryanoff, B. E. (2000). An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics and mechanisms of action. Epilepsia, 41(Suppl 1), S3-S9.
34. Wang, P., Ren, R. N., Cai, S. Y., Chen, X. M., & Ye, L. Y. (2008). Neuroprotective effects of topiramate and folic acid on young rats with kindling-induced epilepsy. Zhongguo Dang Dai Er Ke Za Zhi, 10(1), 65-69
35. White, H. S., Brown, S. D., Woodhead, J. H., Skeen, G. A., & Wolf, H. H. (2000). Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia, 41(Suppl 1), S17-S20.
36. Zhang, X., Velumian, A. A., Jones, O. T., & Carlen, P. L. (2000). Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia, 41(Suppl 1), S52-S60.
37. Zona, C., Ciotti, M. T., & Avoli, M. (1997). Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci Lett, 231, 123-126.