Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells

European Journal of Pharmacology

Volumn 622, Issue 1-3, 2009, Pages 25-31

  Kim, Hyo Shin ^a   Lim, Ji Youn ^b   Sul, Donggeun ^b   Hwang, Bang Yeon ^c   Won, Tae Jun ^a   Hwang, Kwang Woo ^a   Park, So Young ^b  

^a Chung Ang University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Alzheimer's disease; Beta amyloid; CBNU06 (19 hydroxy 1 ,6 diacetoxy 6,7 seco ent kaur 16 en 15 one 7,20 olide); NF kappaB; PC12 cells

Indexed keywords

19 HYDROXY 1ALPHA,6 DIACETOXY 6,7 SECO ENT KAUR 16 EN 15 ONE 7,20 OLIDE; AMYLOID BETA PROTEIN[25-35]; CBNU 06; CYCLOOXYGENASE 2; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR KAPPA B P50 SUBUNIT; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR RELA; TRYPAN BLUE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL LABELING; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; INHIBITION KINETICS; ISODON; ISODON JAPONICUS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELL NUCLEUS; CYCLOOXYGENASE 2; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN TRANSPORT; RATS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 70349866325     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.007     Document Type: Article

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