Deciphering the Distinct Role for the Metal Coordination Motif in the Catalytic Activity of Mycobacterium smegmatis Topoisomerase I

Journal of Molecular Biology

Volumn 393, Issue 4, 2009, Pages 788-802

  Bhat, Anuradha Gopal ^a   Leelaram, Majety Naga ^a   Hegde, Shivanand Manjunath ^a   Nagaraja, Valakunja ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

DNA relaxation; metal coordination; mycobacteria; topoisomerase I; toprim domain

Indexed keywords

ALANINE; DNA TOPOISOMERASE; MAGNESIUM ION;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA CLEAVAGE; METAL BINDING; MUTATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DNA TOPOISOMERASES, TYPE I; DNA, BACTERIAL; HUMANS; MAGNESIUM; METALS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYCOBACTERIUM SMEGMATIS; NUCLEIC ACID CONFORMATION; SEQUENCE ALIGNMENT;

EID: 70349795296     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.08.064     Document Type: Article

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