Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 3, 1999, Pages 881-886

  Liu, Q ^a   Wang, J C ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Alanine substitution mutagenesis; DNA protein transesterification; Enzyme mechanism; Quinolone binding pocket

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING);

ARTICLE; CATALYSIS; DNA DAMAGE; DNA DETERMINATION; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; YEAST;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; DIMERIZATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; MACROMOLECULAR SUBSTANCES; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE;

EID: 0033514360     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.3.881     Document Type: Article

References (25)