The acidic triad conserved in type IA DNA topoisomerases is required for binding of Mg(II) and subsequent conformational change

Journal of Biological Chemistry

Volumn 275, Issue 8, 2000, Pages 5318-5322

  Zhu, Chang Xi ^a   Tse Dinh, Yuk Ching ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; MAGNESIUM;

AMINO ACID ANALYSIS; ARTICLE; BINDING SITE; ENZYME BINDING; ENZYME STRUCTURE; METAL BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALANINE; BINDING SITES; CONSERVED SEQUENCE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MAGNESIUM; MAGNESIUM CHLORIDE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE;

EID: 0034008773     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.8.5318     Document Type: Article

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