Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to E. coli

Journal of Molecular Biology

Volumn 385, Issue 2, 2009, Pages 558-567

  Cheng, Bokun ^a   Annamalai, Thirunavukkarasu ^a   Sorokin, Elena ^a   Abrenica, Maria ^a   Aedo, Sandra ^a   Tse Dinh, Yuk Ching ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

bactericidal; DNA cleavage; DNA religation; topoisomerase; TOPRIM

Indexed keywords

ARABINOSE; ASPARAGINE; ASPARTIC ACID; BACTERIAL ENZYME; DNA TOPOISOMERASE; GLUCOSE; PROTEIN BAD;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL MUTATION; BINDING AFFINITY; CELL DEATH; CELL KILLING; CELL VIABILITY; CLONE; DNA CLEAVAGE; ENZYME INHIBITION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; REVERTANT; SITE DIRECTED MUTAGENESIS; WILD TYPE; YERSINIA PESTIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; YERSINIA PESTIS;

EID: 58149083577     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.10.073     Document Type: Article

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