Anti-inflammatory profile of some synthesized heterocyclic pyridone and pyridine derivatives fused with steroidal structure

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4341-4352

  Amr, Abdel Galil E ^a   Abdulla, Mohamed M ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Hi Care Pharmaceutical Co   (Egypt)

Author keywords

Anti inflammatory; Cyanopyridine; Cyanopyridone; Prednisolone ; Thiopyridone

Indexed keywords

2 ETHOXY 3 CYANO 6 (4 FLUOROPHENYL)ANDROST[17,16 D]PYRIDINE 3BETA OL; 2 ETHOXY 3 CYANO 6 (4 METHYLPHENYL)ANDROST 3 ENE[17,16 D]PYRIDINE 3BETA OL; 2 ETHOXY 3 CYANO 6 (4 METHYLPHENYL)ANDROST[17,16 D]PYRIDINE 3BETA OL; 2 OXO 3 CYANO 6 (4 CHLOROPHENYL)ANDROST 4 ENE[17,16 C]PYRIDO 3 ONE; 2 OXO 3 CYANO 6 (4 CHLOROPHENYL)ANDROST 5 ENE[17,16 C]PYRIDO 3 ONE; 2 OXO 3 CYANO 6 (4 CHLOROPHENYL)ANDROST 5 ENE[17,16 C]PYRIDO 3BETA OL; 2 OXO 3 CYANO 6 (4 FLUOROPHENYL)ANDROST 3 ENE[17,16 C]PYRIDONE; 2 OXO 3 CYANO 6 (4 FLUOROPHENYL)ANDROSTANO[17,16 C]PYRIDO 3 ONE; 2 OXO 3 CYANO 6 (4 FLUOROPHENYL)ANDROSTENO[17,16 C]PYRIDON 3BETA OL; 2 OXO 3 CYANO 6 (4 METHYLPHENYL)ANDROST 3 ENE[17,16 C]PYRIDONE; 2 OXO 3 CYANO 6 (4 METHYLPHENYL)ANDROSTANO[17,16 C]PYRIDO 3 ONE; 2 OXO 3 CYANO 6 (4 METHYLPHENYL)ANDROSTENO[17,16 C]PYRIDON 3BETA OL; 3 CYANO 2 THIOXO 6 (4 CHLOROPHENYL)ANDROST 4 ENE[17,16 D]PYRIDO 3 ONE; 3 CYANO 2 THIOXO 6 (4 CHLOROPHENYL)ANDROST 5 ENE[17,16 D]PYRIDO 3 ONE; 3 CYANO 2 THIOXO 6 (4 FLUOROPHENYL)ANDROSTANO[17,16 D]PYRIDO 3 ONE; 3 CYANO 2 THIOXO 6 (4 FLUOROPHENYL)ANDROSTANO[17,16 D]PYRIDO 3BETA OL; 3 CYANO 2 THIOXO 6 (4 METHYLPHENYL)ANDROSTANO[17,16 D]PYRIDO 3 ONE; 3 CYANO 2 THIOXO 6 (4 METHYLPHENYL)ANDROSTANO[17,16 D]PYRIDO 3BETA OL; 3 CYANO 6 (4 CHLOROPHENYL)ANDROST 3,5 DIENE[17,16 C]PYRID 2 ONE; 3 CYANO THIOXO 6 (4 CHLOROPHENYL)ANDROST 5 ONE[17,16 D]PYRIDO 3BETA ONE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; MELOXICAM; PREDNISOLONE; PROSTAGLANDIN E2; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; TENOXICAM; TILOCTIL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; LD 50; MALE; NONHUMAN; PROSTAGLANDIN BLOOD LEVEL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITORS; DRUG EVALUATION, PRECLINICAL; EDEMA; HETEROCYCLIC COMPOUNDS; LETHAL DOSE 50; MALE; PYRIDINES; PYRIDONES; RATS; RATS, INBRED STRAINS; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646544741     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.045     Document Type: Article

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