Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT(1A) receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 9, 1999, Pages 1648-1660

  Vacher, Bernard ^a   Bonnaud, Bernard ^a   Funes, Philippe ^a   Jubault, Nathalie ^a   Koek, Wouter ^a   Assié, Marie Bernadette ^a   Cosi, Cristina ^a   Kleven, Mark ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 PYRIDINEMETHYLAMINE DERIVATIVE; 3 CHLORO 4 FLUOROPHENYL [4 FLUORO 4 [[(5 METHYL 6 METHYLAMINOPYRIDIN 2 YLMETHYL)AMINO]METHYL]PIPERIDIN 1 YL]METHANONE; ANTIDEPRESSANT AGENT; CYCLIC AMP; IMIPRAMINE; SEROTONIN 1A AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FORCED SWIMMING TEST; HELA CELL; HUMAN; HUMAN CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; LIGANDS; MALE; MOTOR ACTIVITY; PIPERIDINES; PYRIDINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033529013     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9806906     Document Type: Article

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