Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain

Journal of Biological Chemistry

Volumn 280, Issue 7, 2005, Pages 5870-5874

  Govindarajan, Baskaran ^a   Brat, Daniel J ^a   Csete, Marie ^a   Martin, William D ^a   Murad, Emma ^a   Litani, Karin ^a   Cohen, Cynthia ^a   Cerimele, Francesca ^a   Nunnelley, Matthew ^a   Lefkove, Benjamin ^a   Yamamoto, Toshiyuki ^b   Lee, Chunsik ^c,d   Arbiser, Jack L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UPPSALA UNIVERSITY   (Sweden)

^d ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; BRAIN; OXYGEN; SKIN; TISSUE;

HAMARTIN; HUMAN GENETIC DISORDERS; TUBERIN; TUBEROUS SCLEROSIS (TS);

GENES;

HAMARTIN; RAP PROTEIN; REACTIVE OXYGEN METABOLITE; TUBERIN; VASCULOTROPIN;

ALLELE; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; AUTOSOMAL DOMINANT INHERITANCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOMEGALOVIRUS; EMBRYO; FEMALE; GENE DELETION; GENE LOSS; GRANULE CELL; HAMARTOMA; HETEROZYGOSITY LOSS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; TISSUE SPECIFICITY; TRANSGENIC MOUSE; TUBEROUS SCLEROSIS;

ALLELES; ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CHEMOKINE CCL2; GENES, DOMINANT; MICE; MICE, TRANSGENIC; MUSCLE FIBERS; MUTATION; NIH 3T3 CELLS; ORGAN SPECIFICITY; PHENOTYPE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); REACTIVE OXYGEN SPECIES; RECEPTORS, CHEMOKINE; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RNA, MESSENGER; SKIN NEOPLASMS; TRANSGENES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; CYTOMEGALOVIRUS; INFLECTARIUS INFLECTUS; MURINAE; MUS MUSCULUS;

EID: 20044370087     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411768200     Document Type: Article

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