Adenosine, ketogenic diet and epilepsy: The emerging therapeutic relationship between metabolism and brain activity

Current Neuropharmacology

Volumn 7, Issue 3, 2009, Pages 257-268

  Masino, Susan A ^a   Kawamura Jr , M ^a   Wasser, C A ^a   Pomeroy, L T ^a   Ruskin, D N ^a  

^a TRINITY COLLEGE   (United States)

Author keywords

Addiction; Autism; Dopamine; Metabolism; Neurodegeneration; Neuroprotection; Pain; Sleep

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; OPIATE;

AUTISM; BIOENERGY; BRAIN FUNCTION; BRAIN INJURY; CLINICAL TRIAL; DRUG MECHANISM; ENERGY METABOLISM; EPILEPSY; HUMAN; INFLAMMATION; KETOGENIC DIET; METABOLIC SYNDROME X; METABOLISM; NERVE CELL EXCITABILITY; NERVE DEGENERATION; NEUROLOGIC DISEASE; NEUROMODULATION; NEUROPATHIC PAIN; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; REGULATORY MECHANISM; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SLEEP;

EID: 70349705584     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157015909789152164     Document Type: Review

References (203)

1. Adibhatla, R.M., Hatcher, J.F. (2008) Altered lipid metabolism in brain injury and disorders. Subcell. Biochem., 49, 241-268.
2. Afaghi, A., O'Connor, H., Chow, C.M. (2008) Acute effects of the very low carbohydrate diet on sleep indices. Nutr. Neurosci., 11, 146-154.
3. Amatniek, J.C., Hauser, W.A., DelCastillo-Castaneda, C., Jacobs, D.M., Marder, K., Bell, K., Albert, M., Brandt, J., Stern, Y. (2006) Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia, 47, 867-872.
4. Auestad, N., Korsak, R.A., Morrow, J.W., Edmond, J. (1991) Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J. Neurochem., 56, 1376-1386.
5. Baborka, C.J. (1930) Epilepsy in adults: results of treatment by ketogenic diet in one hundred cases. Arch. Neurol., 6, 904-914.
6. Balietti, M., Giorgetti, B., Fattoretti, P., Grossi, Y., Di Stefano, G., Casoli, T., Platano, D., Solazzi, M., Orlando, F., Aicardi, G., Bertoni-Freddari, C. (2008) Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats. Rejuvenation Res., 11, 631-640.
7. Barañano, K.W., Hartman, A.L. (2008) The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr. Treat. Options Neurol., 10, 410-419.
8. Basheer, R., Strecker, R.E., Thakkar, M.M., McCarley, R.W. (2004) Adenosine and sleep-wake regulation. Prog. Neurobiol., 73, 379-396.
9. Belfrage, M., Segerdahl, M., Arnér, S., Sollevi, A. (1999) The safety and efficacy of intrathecal adenosine in patients with chronic neuropathic pain. Anesth. Analg., 89, 136-142.
10. Belfrage, M., Sollevi, A., Segerdahl, M., Sjölund, K.F., Hansson, P. (1995) Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. Anesth. Analg., 81, 713-717.
11. Berman, R.F., Fredholm, B.B., Aden, U., O'Connor, W.T. (2000) Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats. Brain Res., 872, 44-53.
12. Bishnoi, M., Chopra, K., Kulkarni, S.K. (2007) Protective effect of adenosine reuptake inhibitors in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes. Pharmacology, 79, 171-183.
13. Blanquart, C., Barbier, O., Fruchart, J.C., Staels, B., Glineur, C. (2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J. Steroid Biochem. Mol. Biol., 85, 267-273.
14. Blum, D., Gall, D., Galas, M.C., d'Alcantara, P., Bantubungi, K., Schiffmann, S.N. (2002) The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. J. Neurosci., 22, 9122-9133.
15. Bodenant, M., Moreau, C., Sejourné, C., Auvin, S., Delval, A., Cuisset, J.M., Derambure, P., Destée, A., Defebvre, L. (2008) Interest of the ketogenic diet in a refractory status epilepticus in adults. Rev. Neurol. (Paris), 164, 194-199.
16. Boison, D. (2007) Adenosine-based cell therapy approaches for pharmacoresistant epilepsies. Neurodegener. Dis., 4, 28-33.
17. Boison, D. (2008) Adenosine as a neuromodulator in neurological diseases. Curr. Opin. Pharmacol., 8, 2-7.
18. Boison, D. (2008) The adenosine kinase hypothesis of epileptogenesis. Prog. Neurobiol., 84, 249-262.
19. Bottini, N., De Luca, D., Saccucci, P., Fiumara, A., Elia, M., Porfirio, M.C., Lucarelli, P., Curatolo, P. (2001) Autism: evidence of association with adenosine deaminase genetic polymorphism. Neurogenetics, 3, 111-113.
20. Bough, K.J., Wetherington, J., Hassel, B., Pare, J.F., Gawryluk, J.W., Greene, J.G., Shaw, R., Smith, Y., Geiger, J.D., Dingledine, R.J. (2006) Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann. Neurol., 60, 223-235.
21. Brambilla, D., Chapman, D., Greene, R. (2005) Adenosine mediation of presynaptic feedback inhibition of glutamate release. Neuron, 46, 275-283.
22. Calabresi, P., Centonze, D., Pisani, A., Bernardi, G. (1997) Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses. J. Neurosci., 17, 4509-4516.
23. Caruso, C.C. (2006) Possible broad impacts of long work hours. Ind. Health, 44, 531-536.
24. Chalfant, A.M., Rapee, R., Carroll, L. (2007) Treating anxiety disorders in children with high functioning autism spectrum disorders: a controlled trial. J. Autism Dev. Disord., 37, 1842-1857.
25. Chen, F., Lemonnier, E., Lazartigues, A., Planche, P. (2006) Sleep problems and information processing, a "disconnection effect" in autism? Med. Hypotheses, 66, 1245-1246.
26. Chez, M.G., Chang, M., Krasne, V., Coughlan, C., Kominsky, M., Schwartz, A. (2006) Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy Behav., 8, 267-271.
27. Cullingford, T.E., Dolphin, C.T., Sato, H. (2002) The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. Neuropharmacology, 42, 724-730.
28. Cullingford, T.E., Eagles, D.A., Sato, H. (2002) The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain. Epilepsy Res., 49, 99-107.
29. Cunha, R.A. (2001) Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem. Int., 38, 107-125.
30. Curran, L.K., Newschaffer, C.J., Lee, L.C., Crawford, S.O., Johnston, M.V., Zimmerman, A.W. (2007) Behaviors associated with fever in children with autism spectrum disorders. Pediatrics, 120, e1386-e1392.
31. Curros-Criado, M.M., Herrero, J.F. (2005) The antinociceptive effects of the systemic adenosine A1 receptor agonist CPA in the absence and in the presence of spinal cord sensitization. Pharmacol. Biochem. Behav., 82, 721-726.
32. Cuzzocrea, S., Mazzon, E., Dugo, L., Patel, N.S., Serraino, I., Di Paolo, R., Genovese, T., Britti, D., De Maio, M., Caputi, A.P., Thiemermann, C. (2003) Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Arthritis Rheum., 48, 3544-3556.
33. Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Maffia, P., Patel, N.S., Di Paola, R., Ialenti, A., Genovese, T., Chatterjee, P.K., Di Rosa, M., Caputi, A.P., Thiemermann, C. (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. Eur. J. Pharmacol., 483, 79-93.
34. Dale, N., Pearson, T., Frenguelli, B.G. (2000) Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J. Physiol., 526, 143-155.
35. Davis, L.M., Pauly, J.R., Readnower, R.D., Rho, J.M., Sullivan, P.G. (2008) Fasting is neuroprotective following traumatic brain injury. J. Neurosci. Res., 86, 1812-1822.
36. de Mendonça, A., Almeida, T., Bashir, Z.I., Ribeiro, J.A. (1997) Endogenous adenosine attenuates long-term depression and depotentiation in the CA1 region of the rat hippocampus. Neuropharmacology, 36, 161-167.
37. DeVivo, D.C., Leckie, M.P., Ferrendelli, J.S., McDougal, D.B., Jr. (1978) Chronic ketosis and cerebral metabolism. Ann. Neurol., 3, 331-337.
38. DiMario, F.J., Jr., Holland, J. (2002) The ketogenic diet: a review of the experience at Connecticut Children's Medical Center. Pediatr. Neurol., 26, 288-292.
39. Dionyssopoulos, T., Hope, W., Coupar, I.M. (1992) Effect of adenosine analogues on the expression of opiate withdrawal in rats. Pharmacol. Biochem. Behav., 42, 201-206.
40. Doolette, D.J. (1997) Mechanism of adenosine accumulation in the hippocampal slice during energy deprivation. Neurochem. Int., 30, 211-223.
41. Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.J., Mattson, M.P. (2003) Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. USA, 100, 2911-2916.
42. CO2 to cortical excitability via pH. Neuron, 48, 1011-1023.
43. Dunwiddie, T.V. (1999) Adenosine and suppression of seizures. Adv. Neurol., 79, 1001-1010.
44. Dunwiddie, T.V., Diao, L.H., Proctor, W.R. (1997) Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J. Neurosci., 17, 7673-7682.
45. Dunwiddie, T.V., Masino, S.A. (2001) The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci., 24, 31-55.
46. During, M.J., Spencer, D.D. (1993) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann. Neurol., 32, 618-624.
47. Dworak, M., Diel, P., Voss, S., Hollmann, W., Strüder, H.K. (2007) Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep drive. Neuroscience, 150, 789-795.
48. Eagles, D.A., Chapman, G.B. (2007) A light- and electron-microscope study of hepatocytes of rats fed different diets. C. R. Biol., 330, 62-70.
49. Edelson, S.M., Edelson, M.G., Kerr, D.C., Grandin, T. (1999) Behavioral and physiological effects of deep pressure on children with autism: a pilot study evaluating the efficacy of Grandin's Hug Machine. Am. J. Occup. Ther., 53, 145-152.
50. Eisenach, J.C., Rauck, R.L., Curry, R. (2003) Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain. Pain, 105, 65-70.
51. Elzein, E., Zablocki, J. (2008) A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin. Investig. Drugs, 17, 1901-1910.
52. Etherington, L.A., Patterson, G.E., Meechan, L., Boison, D., Irving, A.J., Dale, N., Frenguelli, B. (2008) Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacology, 56, 429-437.
53. Evangeliou, A., Vlachonikolis, I., Mihailidou, H., Spilioti, M., Skarpalezou, A., Makaronas, N., Prokopiou, A., Christodoulou, P., Liapi-Adamidou, G., Helidonis, E., Sbyrakis, S., Smeitink, J. (2003) Application of a ketogenic diet in children with autistic behavior: pilot study. J. Child Neurol., 18, 113-118.
54. Ferré, S., Agnati, L.F., Ciruela, F., Lluis, C., Woods, A.S., Fuxe, K., Franco, R. (2007) Neurotransmitter receptor heteromers and their integrative role in 'local modules': The striatal spine module. Brain Res. Rev., 55, 55-67.
55. Fowler, J.C. (1989) Adenosine antagonists delay hypoxia-induced depression of neuronal activity in hippocampal brain slice. Brain Res., 490, 378-384.
56. Fowler, J.C. (1990) Adenosine antagonists alter the synaptic response to in vitro ischemia in the rat hippocampus. Brain Res., 509, 331-334.
57. Fowler, J.C. (1993) Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices. Neurosci. Lett., 157, 83-86.
58. Fredholm, B.B. (1995) Purinoceptors in the nervous system. Pharmacol. Toxicol., 76, 228-239.
59. Fredholm, B.B. (2007) Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ., 14, 1315-1323.
60. Fredholm, B.B., Bättig, K., Holmén, J., Nehlig, A., Zvartau, E.E. (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev., 51, 83-133.
61. Fredholm, B.B., Jonzon, B., Lindstrom, K. (1983) Adenosine receptor mediated increases and decreases in cyclic AMP in hippocampal slices treated with forskolin. Acta Physiol. Scand., 117, 461-463.
62. Freeman, J.M., Vining, E.P., Pillas, D.J., Pyzik, P.L., Casey, J.C., Kelly, L.M. (1998) The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics, 102, 1358-1363.
63. Frenguelli, B.G., Llaudet, E., Dale, N. (2003) High-resolution realtime recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J. Neurochem., 86, 1506-1515.
64. Frenguelli, B.G., Wigmore, G., Llaudet, E., Dale, N. (2007) Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. J. Neurochem., 101, 1400-1413.
65. Fukao, T., Lopaschuk, G.D., Mitchell, G.A. (2004) Pathways and control of ketone body metabolism: on the fringe of lipid metabolism. Prostaglandins Leukot. Essent. Fatty Acids, 70, 243-251.
66. Fuxe, K., Ferré, S., Genedani, S., Franco, R., Agnati, L.F. (2007) Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function. Physiol. Behav., 92, 210-217.
67. Gabriel, A., Klussmann, F.W., Igelmund, P. (1998) Rapid temperature changes induce adenosine-mediated depression of synaptic transmission in hippocampal slices from rats (non-hibernators) but not in slices from golden hamsters (hibernators). Neuroscience, 86, 67-77.
68. 1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis. Am. J. Physiol. Renal Physiol., 289, F369-F376.
69. Garriga-Canut, M., Schoenike, B., Qazi, R., Bergendahl, K., Daley, T.J., Pfender, R.M., Morrison, J.F., Ockuly, J., Stafstrom, C., Sutula, T., Roopra, A. (2006) 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat. Neurosci., 9, 1382-1387.
70. Gasior, M., Rogawski, M.A., Hartman, A.L. (2006) Neuroprotective and disease-modifying effects of the ketogenic diet. Behav. Pharmacol., 17, 431-439.
71. Gianfriddo, M., Corsi, C., Melani, A., Pèzzola, A., Reggio, R., Popoli, P., Pedata, F. (2003) Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease. Brain Res., 979, 225-229.
72. Godbout, R., Bergeron, C., Limoges, E., Stip, E., Mottron, L. (2000) A laboratory study of sleep in Asperger's syndrome. Neuroreport, 11, 127-130.
73. 3H]cyclohexyladenosine. J. Neurosci., 2, 1230-1241.
74. Gouder, N., Fritschy, J.-M., Boison, D. (2003) Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia, 44, 877-885.
75. Gouder, N., Scheurer, L., Fritschy, J.M., Boison, D. (2004) Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J. Neurosci., 24, 692-701.
76. Gourine, A., Bondar, S.I., Spyer, K.M., Gourine, A.V. (2008) Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway. J. Physiol., 586, 3963-3978.
77. Gourine, A.V., Llaudet, E., Dale, N., Spyer, K.M. (2005) ATP is a mediator of chemosensory transduction in the central nervous system. Nature, 436, 108-111.
78. Grandin, T., Scariano, M.M. (1996) Emergence: Labeled Autistic. Warner Books: New York.
79. Guieu, R., Couraud, F., Pouget, J., Sampieri, F., Bechis, G., Rochat, H. (1996) Adenosine and the nervous system: clinical implications. Clin. Neuropharmacol., 19, 459-474.
80. Haas, R.H., Rice, M.A., Tauner, D.A., Merritt, T.A. (1986) Therapeutic effects of a ketogenic diet in Rett syndrome. Am. J. Med. Genet. Suppl., 1, 225-246.
81. Haces, M.L., Hernandez-Fonseca, K., Medina-Campos, O.N., Montiel, T., Pedraza-Chaverri, J., Massieu, L. (2008) Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions. Exp. Neurol., 211, 85-96.
82. Halassa, M.M., Florian, C., Fellin, T., Munoz, J.R., Lee, S.Y., Abel, T., Haydon, P.G., Frank, M.G. (2009) Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron, 61, 213-219.
83. Hallböök, T., Lundgren, J., Rosén, I. (2007) Ketogenic diet improves sleep quality in children with therapy-resistant epilepsy. Epilepsia, 48, 59-65.
84. Herrero Matteo, L.M., Ros Die, E., Sanchez Fernandes-Bravo, J. (1977) [Changes in the muscular pH and other parameters of tissue hypoxia during prolonged and intense exercise. Angiología, 29, 118-134.
85. Higdon, J.V., Frei, B. (2006) Coffee and health: a review of recent human research. Crit. Rev. Food Sci. Nutr., 46, 101-123.
86. Hill, C.M., Hogan, A.M., Karmiloff-Smith, A. (2007) To sleep, perchance to enrich learning? Arch. Dis. Child., 92, 637-643.
87. Hornig, M., Lipkin, W.I. (2001) Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models. Ment. Retard. Dev. Disabil. Res. Rev., 7, 200-210.
88. Huang, Z.L., Qu, W.M., Eguchi, N., Chen, J.F., Schwarzschild, M.A., Fredholm, B.B., Urade, Y., Hayaishi, O. (2005) Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat. Neurosci., 8, 858-859.
89. Huber, A., Padrun, V., Déglon, N., Aebischer, P., Möhler, H., Boison, D. (2001) Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc. Natl. Acad. Sci. USA, 98, 7611-7616.
90. 1 receptor. Proc. Natl. Acad. Sci. USA, 98, 9407-9412.
91. Jyonouchi, H., Sun, S., Le, H. (2001) Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J. Neuroimmunol., 120, 170-179.
92. Kafka, S.H., Corbett, R. (1996) Selective adenosine A 2A receptor dopamine D 2 receptor interactions in animal models of schizophrenia. Eur. J. Pharmacol., 295, 147-154.
93. Kaku, T., Jiang, M.H., Hada, J., Morimoto, K., Hayashi, Y. (2001) Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus. Eur. J. Pharmacol., 413, 199-205.
94. Kalinchuk, A.V., McCarley, R.W., Stenberg, D., Porkka-Heiskanen, T., Basheer, R. (2008) The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience, 157, 238-253.
95. Kashiwaya, Y., Sato, K., Tsuchiya, N., Thomas, S., Fell, D.A., Veech, R.L., Passonneau, J.V. (1994) Control of glucose utilization in working perfused rat heart. J. Biol. Chem., 269, 25502-25514.
96. Kawamura, M., Jr., Masino, S.A. (2008) Purinergic autocrine regulation of CA3 pyramidal neurons: activation of adenosine A1 receptors in the rat hippocampus. Soc. Neurosci. Abstr., 825.26.
97. Kebabian, J.W., Calne, D.B. (1979) Multiple receptors for dopamine. Nature, 277, 93-96.
98. Kern, L., Koegel, R.L., Dunlap, G. (1984) The influence of vigorous versus mild exercise on autistic stereotyped behaviors. J. Autism Dev. Disord., 14, 57-67.
99. Kim, D., Rho, J. (2007) Ketone bodies potect against impairment of synaptic transmission in rat hippocampal slices by mitochondrial respiratory inhibitors. Soc. Neurosci. Abstr., 786.713.
100. Klotz, K.N. (2000) Adenosine receptors and their ligands. Naunyn-Schmeidebergs Arch. Pharmacol., 362, 382-391.
101. Knapp, C.M., Foye, M.M., Cottam, N., Ciraulo, D.A., Kornetsky, C. (2001) Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol. Biochem. Behav., 68, 797-803.
102. Korde, A.S., Pettigrew, L.C., Craddock, S.D., Maragos, W.F. (2005) The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia. J. Neurochem., 94, 1676-1684.
103. Kossoff, E.H., Dorward, J.L. (2008) The modified Atkins diet. Epilepsia, 49 (Suppl 8), 37-41.
104. Kossoff, E.H., Krauss, G.L., McGrogan, J.R., Freeman, J.M. (2003) Efficacy of the Atkins diet as therapy for intractable epilepsy. Neurology, 61, 1789-1791.
105. Kotagal, P., Yardi, N. (2008) The relationship between sleep and epilepsy. Semin. Pediatr. Neurol., 15, 42-49.
106. Kwan, R.M., Thomas, S., Mir, M.A. (1986) Effects of a low carbohydrate isoenergetic diet on sleep behavior and pulmonary functions in healthy female adult humans. J. Nutr., 116, 2393-2402.
107. Lara, D.R., Brunstein, M.G., Ghisolfi, E.S., Lobato, M.I., Belmonte-de-Abreu, P., Souza, D.O. (2001) Allopurinol augmentation for poorly responsive schizophrenia. Int. Clin. Psychopharmacol., 16, 235-237.
108. Latini, S., Corsi, C., Pedata, F., Pepeu, G. (1995) The source of brain adenosine outflow during ischemia and electrical stimulation. Neurochem. Int., 27, 239-244.
109. Latini, S., Pedata, F. (2001) Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J. Neurochem., 79, 463-484.
110. Lee, H.T., Xu, H., Nasr, S.H., Schnermann, J., Emala, C.W. (2004) A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion. Am. J. Physiol. Renal Physiol., 286, F298-F306.
111. Lee, J., Bruce-Keller, A.J., Kruman, Y., Chan, S.L., Mattson, M.P. (1999) 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins. J. Neurosci. Res., 57, 48-61.
112. Lee, Y.-W., Yaksh, T.L. (1996) Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J. Pharmacol. Exp. Ther., 277, 1642-1648.
113. Listos, J., Talarek, S., Fidecka, S. (2008) Involvement of adenosine receptor agonists on the development of hypersensitivity to acute dose of morphine during morphine withdrawal period. Pharmacol. Rep., 60, 679-685.
114. Lloyd, H.G., Lindström, K., Fredholm, B.B. (1993) Intracellular formation and release of adenosine from rat hippocampal slices evoked by electrical stimulation or energy depletion. Neurochem. Int., 23, 173-185.
115. LoVerme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., Piomelli, D. (2005) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol. Pharmacol., 67, 15-19.
116. Ma, T.C., Buescher, J.L., Oatis, B., Funk, J.A., Nash, A.J., Carrier, R.L., Hoyt, K.R. (2007) Metformin therapy in a transgenic mouse model of Huntington's disease. Neurosci. Lett., 411, 98-103.
117. Maalouf, M., Sullivan, P.G., Davis, L., Kim, D.Y., Rho, J.M. (2007) Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience, 145, 256-264.
118. Malow, B.A. (2004) Sleep disorders, epilepsy, and autism. Ment. Retard. Dev. Disabil. Res. Rev., 10, 122-125.
119. Manzoni, O.J., Manabe, T., Nicoll, R.A. (1994) Release of adenosine by activation of NMDA receptors in the hippocampus. Science, 265, 2098-2101.
120. Marie, S., Race, V., Nassogne, M.C., Vincent, M.F., Van den Berghe, G. (2002) Mutation of a nuclear respiratory factor 2 binding site in the 5′ untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. Am. J. Hum. Genet., 71, 14-21.
121. Marsh, J., Mukherjee, P., Seyfried, T.N. (2008) Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr. Metab. (Lond.), 5, 33.
122. Martin, B., Golden, E., Carlson, O.D., Pistell, P., Zhou, J., Kim, W., Frank, B.P., Thomas, S., Chadwick, W.A., Greig, N.H., Bates, G.P., Santhasivam, K., Bernier, M., Maudsley, S., Mattson, M.P., Egan, J.M. (2009) Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes, 58, 318-328.
123. Martín, E.D., Fernández, M., Perea, G., Pascual, O., Haydon, P.G., Araque, A., Ceña, V. (2007) Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission. Glia, 55, 36-45.
124. Masino, S.A., Dunwiddie, T.V. (1999) Temperature-dependent modulation of excitatory transmission in hippocampal slices is mediated by extracellular adenosine. J. Neurosci., 19, 1932-1939.
125. Masino, S.A., Geiger, J.D. (2008) Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci., 31, 273-278.
126. Masino, S.A., Geiger, J.D. (2009) The ketogenic diet and epilepsy: Is adenosine the missing link? Epilepsia, 50, 332-333.
127. Masino, S.A., Gockel, J.A., Wasser, C.A., Pomeroy, L.T., Wagener, J.F., Gawryluk, J.W., Geiger, J.D. (2007) The relationship among ATP, adenosine and a ketogenic diet. Soc. Neurosci. Abstr., 595.512.
128. Masino, S.A., Latini, S., Bordoni, F., Pedata, F., Dunwiddie, T.V. (2001) Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature. Synapse, 41, 58-64.
129. Masino, S.A., Mesches, M.H., Bickford, P.C., Dunwiddie, T.V. (1999) Acute peroxide treatment of rat hippocampal slices induced adenosine-mediated inhibition of excitatory transmission in area CA1. Neurosci. Lett., 274, 91-94.
130. Melani, A., Corsi, C., Giménez-Llort, L., Martínez, E., Ogren, S.O., Pedata, F., Ferré, S. (1999) Effect of N-methyl-D-aspartate on motor activity and in vivo adenosine striatal outflow in the rat. Eur. J. Pharmacol., 385, 15-19.
131. Minor, T.R., Rowe, M.K., Soames Job, R.F., Ferguson, E.C. (2001) Escape deficits induced by inescapable shock and metabolic stress are reversed by adenosine receptor antagonists. Behav. Brain Res., 120, 203-212.
132. Mitchell, J.B., Lupica, C.R., Dunwiddie, T.V. (1993) Activity-dependent release of endogenous adenosine modulates synaptic responses in the rat hippocampus. J. Neurosci., 13, 3439-3447.
133. Murillo-Rodriguez, E., Liu, M., Blanco-Centurion, C., Shiromani, P.J. (2008) Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. Eur. J. Neurosci., 28, 1191-1198.
134. Nakazawa, M., Kodama, S., Matsuo, T. (1983) Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotides. Brain Dev., 5, 375-380.
135. Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., Whitney, A., Cross, J.H. (2008) The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol., 7, 500-506.
136. Nehlig, A., Daval, J.L., Debry, G. (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res. Brain Res. Rev., 17, 139-170.
137. Nemeth, P.M., Rosser, B.W., Choksi, R.M., Norris, B.J., Baker, K.M. (1992) Metabolic response to a high-fat diet in neonatal and adult rat muscle. Am. J. Physiol. Cell Physiol., 262, C282-C286.
138. Newby, A.C. (1984) Adenosine and the concept of "retaliatory metabolites." Trends Biochem. Sci., 9, 42-44.
139. Newcomer, J.W. (2004) Metabolic risk during antipsychotic treatment. Clin. Ther., 26, 1936-1946.
140. Niglio, T., Popoli, P., Caporali, M.G., Scotti de Carolis, A. (1988) Antiepileptic effects of N6-L-phenylisopropyladenosine (L-PIA) on penicillin-induced epileptogenic focus in rabbits. Pharmacol. Res. Commun., 20, 561-572.
141. Noh, H.S., Lee, H.P., Kim, D.W., Kang, S.S., Cho, G.J., Rho, J.M., Choi, W.S. (2004) A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet. Mol. Brain Res., 129, 80-87.
142. Nyhan, W.L., James, J.A., Teberg, A.J., Sweetman, L., Nelson, L.G. (1969) A new disorder of purine metabolism with behavioral manifestations. J. Pediatr., 74, 20-27.
143. Nylen, K., Velazquez, J.L., Sayed, V., Gibson, K.M., Burnham, W.M., Snead, O.C., 3rd (2009) The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1(-/ -) mice. Biochim. Biophys. Acta, in press.
144. O'Neill, M.F. (2005) Study focuses in on potential cause of antipsychotic-induced diabetes. Drug News Perspect., 18, 481-482.
145. Orford, M.R., Saggerson, E.D. (1996) A low-Km 5′-nucleotidase from rat brain cytosolic fraction: purification, kinetic properties, and description of regulation by a novel factor that increases sensitivity to inhibition by ATP and ADP. J. Neurochem., 67, 795-804.
146. Otsuguro, K., Yamaji, Y., Ban, M., Ohta, T., Ito, S. (2006) Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats. J. Physiol., 574, 835-847.
147. Owen, O.E., Morgan, A.P., Kemp, H.G., Sullivan, J.M., Herrera, M.G., Cahill, G.F., Jr. (1967) Brain metabolism during fasting. J. Clin. Invest., 46, 1589-1595.
148. Pacheco, A., Easterling, W.S., Pryer, M.W. (1965) A pilot study of the ketogenic diet in schizophrenia. Am. J. Psychiatry, 121, 1110-1111.
149. Page, T., Coleman, M. (2000) Purine metabolism abnormalities in a hyperuricosuric subclass of autism. Biochim. Biophys. Acta, 1500, 291-296.
150. Page, T., Moseley, C. (2002) Metabolic treatment of hyperuricosuric autism. Prog. Neuropsychopharmacol. Biol. Psychiatry, 26, 397-400.
151. 31P spectroscopic imaging at 4.1 T. Epilepsia, 40, 703-707.
152. Pandya, J.D., Pauly, J.R., Nukala, V.N., Sebastian, A.H., Day, K.M., Korde, A.S., Maragos, W.F., Hall, E.D., Sullivan, P.G. (2007) Post-injury administration of mitochondrial uncouplers increases tissue sparing and improves behavioral outcome following traumatic brain injury in rodents. J. Neurotrauma, 24, 798-811.
153. Panico, L.R., Ríos, V.G., Demartini, M.G., Carniello, M.A. (2000) [The electroencephalographic evolution of a group of patients on a ketonic diet]. Rev. Neurol., 30, 8-15.
154. Parkinson, F.E., Xiong, W. (2004) Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J. Neurochem., 88, 1305-1312.
155. Parkinson, F.E., Xiong, W., Zamzow, C.R. (2005) Astrocytes and neurons: different roles in regulating adenosine levels. Neurol. Res., 27, 153-160.
156. Pascual, O., Casper, K.B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.Y., Takano, H., Moss, S.J., McCarthy, K., Haydon, P.G. (2005) Astrocytic purinergic signaling coordinates synaptic networks. Science, 310, 113-116.
157. Pedata, F., Pazzagli, M., Tilli, S., Pepeu, G. (1990) Regional differences in the electrically stimulated release of endogenous and radioactive adenosine and purine derivatives from rat brain slices. Naunyn Schmeidebergs Arch. Pharmacol., 342, 447-453.
158. Peters, S.J., St. Amand, T.A., Howlett, R.A., Heigenhauser, G.J.F., Spriet, L.L. (1998) Human skeletal muscle pyruvate dehydrogenase kinase activity increases after a low-carbohydrate diet. Am. J. Physiol. Endocrinol. Metab., 275, E980-E986.
159. Phillips, F., Chen, C.N., Crisp, A.H., Koval, J., McGuinness, B., Kalucy, R.S., Kalucy, E.C., Lacey, J.H. (1975) Isocaloric diet changes and electroencephalographic sleep. Lancet, 2, 723-725.
160. Plunet, W.T., Streijger, F., Lam, C.K., Lee, J.H., Liu, J., Tetzlaff, W. (2008) Dietary restriction started after spinal cord injury improves functional recovery. Exp. Neurol., 213, 28-35.
161. Porkka-Heiskanen, T., Strecker, R.E., McCarley, R.W. (2000) Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study. Neuroscience, 99, 507-517.
162. Porkka-Heiskanen, T., Strecker, R.E., Thakkar, M., Bjorkum, A.A., Greene, R.W., McCarley, R.W. (1997) Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science, 276, 1265-1268.
163. Portenoy, R.K., Foley, K.M., Inturrisi, C.E. (1990) The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. Pain, 43, 273-286.
164. Qin, P., Xu, H., Laursen, T.M., Vestergaard, M., Mortensen, P.B. (2005) Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study. BMJ, 331, 23.
165. Radulovacki, M., Miletich, R.S., Green, R.D. (1982) N6 (L-phenylisopropyl) adenosine (L-PHA) increases slow-wave sleep (S2) and decreases wakefulness in rats. Brain Res., 246, 178-180.
166. Rainnie, D.G., Grunze, H.C., McCarley, R.W., Greene, R.W. (1994) Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal. Science, 263, 689-692.
167. Rho, J.M., Sarnat, H.B., Sullivan, P.G., Robbins, C.A., Kim, D.W. (2004) Lack of long-term histopathologic changes in brain and skeletal muscle of mice treated with a ketogenic diet. J. Child Neurol., 19, 555-557.
168. Rogawski, M.A. (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res., 69, 273-294.
169. Rosin, D.L., Hettinger, B.D., Lee, A., Linden, J. (2003) Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function. Neurology, 61, S12-18.
170. Sala-Newby, G.B., Skladanowski, A.C., Newby, A.C. (1999) The mechanism of adenosine formation in cells. Cloning of cytosolic 5′-nucleotidase-I. J. Biol. Chem., 274, 17789-17793.
171. Sampath, A., Kossoff, E.H., Furth, S.L., Pyzik, P.L., Vining, E.P. (2007) Kidney stones and the ketogenic diet: risk factors and prevention. J. Child. Neurol., 22, 375-378.
172. Saransaari, P., Oja, S.S. (2003) Enhanced release of adenosine under cell-damaging conditions in the developing and adult mouse hippocampus. Neurochem. Res., 28, 1409-1417.
173. Sato, K., Kashiwaya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., Chance, B., Clarke, K., Veech, R.L. (1995) Insulin, ketone bodies, and mitochondrial energy transfer. FASEB J., 9, 651-658.
174. 2 in rats. Proc. Natl. Acad. Sci. USA, 93, 5980-5984.
175. Schubert, P. (1988) Physiological modulation by adenosine: selective blockade of A1-receptors with DPCPX enhances stimulus train-evoked neuronal Ca influx in rat hippocampal slices. Brain Res., 458, 162-165.
176. Semba, K., White, T.D. (1997) M3 muscarinic receptor-mediated enhancement of NMDA-evoked adenosine release in rat cortical slices in vitro. J. Neurochem., 69, 1066-1072.
177. Seyfried, T.N., Mukherjee, P. (2005) Targeting energy metabolism in brain cancer: review and hypothesis. Nutr. Metab., 2, 30.
178. Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., Baird, G. (2008) Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J. Am. Acad. Child Adolesc. Psychiatry, 47, 921-929.
179. Smith, M., Hopkins, D., Peveler, R.C., Holt, R.I., Woodward, M., Ismail, K. (2008) First- v. second-generation antipsychotics and risk for diabetes in schizophrenia: systematic review and metaanalysis. Br. J. Psychiatry, 192, 406-411.
180. Sollevi, A. (1997) Adenosine for pain control. Acta Anaesthesiol. Scand. Suppl., 110, 135-136.
181. Stafstrom, C.E., Roopra, A., Sutula, T.P. (2008) Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG). Epilepsia, 49(Suppl 8), 97-100.
182. Sullivan, P.G., Rippy, N.A., Dorenbos, K., Concepcion, R.C., Agarwal, A.K., Rho, J.M. (2004) The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann. Neurol., 55, 576-580.
183. 1 adenosine receptor in adenosine-dependent pulmonary injury. J. Clin. Invest., 115, 35-43.
184. Tierney, E., Nworoko, N.A., Kelley, R.I. (2000) Behavioral phenotype of RSH/Smith-Lemli-Opitz syndrome. Ment. Retard. Dev. Disabil. Res. Rev., 6, 131-134.
185. Tsutsui, S., Schnermann, J., Noorbakhsh, F., Henry, S., Yong, V.W., Winston, B.W., Warren, K., Power, C. (2004) A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. J. Neurosci., 24, 1521-1529.
186. Varma, H., Cheng, R., Voisine, C., Hart, A.C., Stockwell, B.R. (2007) Inhibitors of metabolism rescue cell death in Huntington's disease models. Proc. Natl. Acad. Sci. USA, 104, 14525-14530.
187. Veech, R.L. (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids, 70, 309-319.
188. Vining, E.P., Freeman, J.M., Ballaban-Gil, K., Camfield, C.S., Camfield, P.R., Holmes, G.L., Shinnar, S., Shuman, R., Trevathan, E., Wheless, J.W. (1998) A multicenter study of the efficacy of the ketogenic diet. Arch. Neurol., 55, 1433-1437.
189. Virus, R.M., Ticho, S., Pilditch, M., Radulovacki, M. (1990) A comparison of the effects of caffeine, 8-cyclopentyltheophylline, and alloxazine on sleep in rats. Possible roles of central nervous system adenosine receptors. Neuropsychopharmacology, 3, 243-249.
190. 1 receptor agonist. Eur. J. Pharmacol., 302, 43-48.
191. Weerts, E.M., Griffiths, R.R. (2003) The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons. Psychopharmacology, 168, 155-163.
192. Westman, E.C., Yancy, W.S., Jr., Mavropoulos, J.C., Marquart, M., McDuffie, J.R. (2008) The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr. Metab. (Lond.), 5, 36.
193. Whitcomb, K., Lupica, C.R., Rosen, J.B., Berman, R.F. (1990) Adenosine involvement in postictal events in amygdala-kindled rats. Epilepsy Res., 6, 171-179.
194. Wilder, R.M. (1921) The effects of ketonemia on the course of epilepsy. Mayo Clin. Proc., 2, 307-308.
195. Wong, V. (1993) Epilepsy in children with autistic spectrum disorder. J. Child Neurol., 8, 316-322.
196. 1 receptor. Pain, 113, 395-404.
197. Xu, K., Bastia, E., Schwarzschild, M. (2005) Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol. Ther., 105, 267-310.
198. Yancy, W.S., Jr., Foy, M., Chalecki, A.M., Vernon, M.C., Westman, E.C. (2005) A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr. Metab. (Lond.), 2, 34.
199. Zhang, J.-M., Wang, H.-K., Ye, C.-Q., Ge, W., Chen, Y., Jiang, Z.-l., Wu, C.-P., Poo, M.-M., Duan, S. (2003) ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression. Neuron, 40, 971-982.
200. Zhao, Y.T., Tekkök, S., Krnjevic, K. (1997) 2-Deoxy-D-glucose-induced changes in membrane potential, input resistance, and excitatory postsynaptic potentials of CA1 hippocampal neurons. Can. J. Physiol. Pharmacol., 75, 368-374.
201. Zhu, P.J., Krnjevic, K. (1993) Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices. Neurosci. Lett., 155, 128-131.
202. Zhu, P.J., Krnjevic, K. (1997) Adenosine release mediates cyanide-induced suppression of CA1 neuronal activity. J. Neurosci., 17, 2355-2364.
203. Ziegler, D.R., Gamaro, G.D., Araujo, E., Bassani, M.G., Perry, M.L.S., Dalmaz, C., Gonçalves, C.-A. (2005) Nociception and locomotor activity are increased in ketogenic diet fed rats. Physiol. Behav., 84, 421-427.