Transfer of rolf S3-S4 linker to hERG eliminates activation gating but spares inactivation

Biophysical Journal

Volumn 97, Issue 5, 2009, Pages 1323-1334

  Choveau, Frank S ^a,b,c   El Harchi, Aziza ^a,b,c,e   Rodriguez, Nicolas ^a,b,c   Louérat Oriou, Bénédicte ^a,b,c   Baró, Isabelle ^a,b,c   Demolombe, Sophie ^a,b,c   Charpentier, Flavien ^a,b,c,d   Loussouarn, Gildas ^a,b,c  

^a INSERM   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d L INSTITUT DU THORAX   (France)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KETOCONAZOLE; POTASSIUM CHANNEL HERG; VOLTAGE GATED POTASSIUM CHANNEL;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CHANNEL GATING; CHIMERA; CONFORMATION; CROSS LINKING; ELECTRIC POTENTIAL; KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PHASE TRANSITION; SENSITIVITY ANALYSIS;

ANALYSIS OF VARIANCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; KETOCONAZOLE; KINETICS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; RATS; RECOMBINANT FUSION PROTEINS; SCORPION VENOMS;

EID: 70349583056     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.05.060     Document Type: Article

References (42)

1. Sanguinetti, M. C., and M. Tristani-Firouzi. 2006. hERG potassium channels and cardiac arrhythmia. Nature. 440:463-469.
2. Wei, A., T. Jegla, and L. Salkoff. 1996. Eight potassium channel families revealed by the C. elegans genome project. Neuropharmacology. 35:805-829. (Pubitemid 26377669)
3. Jan, L. Y., and Y. N. Jan. 1992. Tracing the roots of ion channels. Cell. 69:715-718.
4. Smith, P. L., T. Baukrowitz, and G. Yellen. 1996. The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 379:833-836.
5. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1991. Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxyterminal region. Neuron. 7:547-556.
6. Panyi, G., and C. Deutsch. 2006. Cross talk between activation and slow inactivation gates of Shaker potassium channels. J. Gen. Physiol. 128:547-559.
7. Piper, D. R., A. Varghese, M. C. Sanguinetti, and M. Tristani-Firouzi. 2003. Gating currents associated with intramembrane charge displacement in HERG potassium channels. Proc. Natl. Acad. Sci. USA. 100:10534-10539.
8. + channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation. J. Physiol. 509:129-137.
9. Sanguinetti, M. C., and Q. P. Xu. 1999. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J. Physiol. 514:667-675.
10. + channel. J. Biol. Chem. 281:12858-12864.
11. Mitcheson, J. S., J. Chen, and M. C. Sanguinetti. 2000. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J. Gen. Physiol. 115:229-240.
12. + channel. Science. 309:897-903.
13. + channel. J. Gen. Physiol. 109:301-311.
14. Dumaine, R., M. L. Roy, and A. M. Brown. 1998. Blockade of HERG and Kv1.5 by ketoconazole. J. Pharmacol. Exp. Ther. 286:727-735.
15. + channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. FEBS Lett. 580:1999-2005.
16. Yao, J. A., X. Du, D. Lu, R. L. Baker, E. Daharsh, et al. 2005. Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature. J. Pharmacol. Toxicol. Methods. 52:146-153.
17. + channels. EMBO J. 22:5412-5421.
18. Chevalier, P., C. Rodriguez, L. Bontemps, M. Miquel, G. Kirkorian, et al. 2001. Non-invasive testing of acquired long QT syndrome: evidence for multiple arrhythmogenic substrates. Cardiovasc. Res. 50:386-398.
19. Clancy, C. E., and Y. Rudy. 2001. Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc. Res. 50:301-313.
20. Wang, Z., B. Fermini, and S. Nattel. 1994. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc. Res. 28:1540-1546.
21. Spector, P. S., M. E. Curran, A. Zou, M. T. Keating, and M. C. Sanguinetti. 1996. Fast inactivation causes rectification of the IKr channel. J. Gen. Physiol. 107:611-619.
22. +]o and C-type inactivation. FEBS Lett. 417:43-47.
23. Snyders, D. J., and A. Chaudhary. 1996. High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol. Pharmacol. 49:949-955.
24. Wang, S., S. Liu, M. J. Morales, H. C. Strauss, and R. L. Rasmusson. 1997. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J. Physiol. 502:45-60. (Pubitemid 27322975)
25. + current in cardiac cells. Circ. Res. 80:782-789.
26. Kiehn, J., A. E. Lacerda, and A. M. Brown. 1999. Pathways of HERG inactivation. Am. J. Physiol. 277:H199-H210.
27. Korolkova, Y. V., G. N. Tseng, and E. V. Grishin. 2004. Unique interaction of scorpion toxins with the hERG channel. J. Mol. Recognit. 17:209-217.
28. Milnes, J. T., C. E. Dempsey, J. M. Ridley, O. Crociani, A. Arcangeli, et al. 2003. Preferential closed channel blockade of HERG potassium currents by chemically synthesized BeKm-1 scorpion toxin. FEBS Lett. 547:20-26.
29. + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96:195-215.
30. + channel. Open-channel block by methanesulfonanilides. Circ. Res. 78:499-503.
31. Loots, E., and E. Y. Isacoff. 2000. Molecular coupling of S4 to a K(+) channel's slow inactivation gate. J. Gen. Physiol. 116:623-636.
32. Smith, P. L., and G. Yellen. 2002. Fast and slow voltage sensor movements in HERG potassium channels. J. Gen. Physiol. 119:275-293.
33. Hill, A. P., and J. I. Vandenberg. 2008. Investigating the origin of the voltage-sensitivity of inactivation in hERG potassium channels. Biophys. J. 94:448-459.
34. + channel. J. Biol. Chem. 284:1000-1008.
35. + channels. J. Biol. Chem. 277:18994-19000.
36. +) channel gating kinetics by the S3-S4 linker. J. Gen. Physiol. 115:193-208.
37. Mathur, R., J. Zheng, Y. Yan, and F. J. Sigworth. 1997. Role of the S3-S4 linker in Shaker potassium channel activation. J. Gen. Physiol. 109:191-199.
38. Sorensen, J. B., A. Cha, R. Latorre, E. Rosenman, and F. Bezanilla. 2000. Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups near the outside of S4. J. Gen. Physiol. 115:209-222.
39. + current by antifungal drug miconazole. Br. J. Pharmacol. 144:840-848.
40. + channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br. J. Pharmacol. 147:905-916.
41. Milnes, J. T., O. Crociani, A. Arcangeli, J. C. Hancox, and H. J. Witchel. 2003. Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Br. J. Pharmacol. 139:887-898.
42. Duncan, R. S., M. J. McPate, J. M. Ridley, Z. Gao, A. F. James, et al. 2007. Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin. Biochem. Pharmacol. 74:425-437.