Pleiotropic, cardioprotective effects of omega-3 polyunsaturated fatty acids

Mini-Reviews in Medicinal Chemistry

Volumn 9, Issue 9, 2009, Pages 1030-1039

  Dimitrow, Pawel Petkow ^a   Jawien, Marek ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b Vaccination Outpatient Clinic   (Poland)

Author keywords

Cardioprotection; Omega 3 polyunsaturated fatty acids; Pleiotropic effect

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSANOID; ICOSAPENTAENOIC ACID; INTERLEUKIN 6; ION CHANNEL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHYTOSTEROL; PLACEBO; SIMVASTATIN; SODIUM CHANNEL; TAURINE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CARDIOVASCULAR AGENT;

ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARRHYTHMOGENESIS; ARTERY DISEASE; ASTHMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLEEDING; CALCIUM CURRENT; CARDIOVASCULAR RISK; CELL MEMBRANE; CHANNELOPATHY; CHRONIC INFLAMMATION; CLINICAL TRIAL; CROHN DISEASE; CYTOKINE RELEASE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG POTENTIATION; DRUG STRUCTURE; ENDOTHELIAL DYSFUNCTION; ESKIMO; FAT INTAKE; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HEART PROTECTION; HEMOSTASIS; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOGLYCEMIA; HYPOTENSION; INFLAMMATION; INFORMATION RETRIEVAL; ISCHEMIC HEART DISEASE; LOW DRUG DOSE; LUPUS ERYTHEMATOSUS; MEDLINE; MEMBRANE STABILIZATION; METABOLIC DISORDER; NONHUMAN; PLEIOTROPY; POTASSIUM CURRENT; RENAL PROTECTION; REPOLARIZATION; REVIEW; RISK REDUCTION; SEIZURE; SIDE EFFECT; SODIUM CALCIUM EXCHANGE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOSIS PREVENTION; ANIMAL; CARDIOVASCULAR DISEASE; CHEMISTRY; DIET THERAPY; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; FATTY ACIDS, OMEGA-3; HUMANS;

EID: 70349567219     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955709788922638     Document Type: Review

References (103)

1. Bang, H.O.; Dyerberg, J.; Sinclair, H.M. The composition of the Eskimo food in north western Greenland. Am. J. Clin. Nutr., 1980, 33, 2657-2661.
2. Bang, H.O.; Dyerbert, J. Lipid metabolism and ischemic heart disease in Greenland Eskimos; Draper, H. Ed.; New York, NY: Plenum Press, 1980, pp. 1-22.
3. Kagawa, Y.; Nishizawa, M.; Suzuki, M.; Miyatake, T.; Hamamoto, T.; Goto, K.; Motonaga, E.; Izmikawa, H.; Hirata, H.; Ebihara, A. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. J. Nutr. Sci. Vitaminol. (Tokyo), 1982, 28, 441-453.
4. Bang, H.O.; Dyerberg, J.; Nielsen, A.B. Plasma lipid and lipoprotein pattern in greenlandic west-coast Eskimos. Lancet, 1971, 1, 1143-1145.
5. Dyerberg, J.; Bang, H.O.; Hjorne, N. Fatty amid composition of the plasma lipids in Greenland Eskimos. Am. J. Clin. Nutr., 1975, 28, 958-966.
6. McLennan, P.L.; Bridle, T.M.; Abeywardena, M.Y.; Charnock, J.S. Comparative efficacy of n-3 and n-6 polyunsaturated fatty acids in modulating ventricular fibrillation threshold in marmoset monkeys. Am. J. Clin. Nutr., 1993, 58, 666-669 (Pubitemid 23319954)
7. McLennan, P.L. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am. J. Clin. Nutr., 1993, 57, 207-212 (Pubitemid 23039893)
8. London, B.; Albert, C.; Anderson, M.E.; Giles, W.R.; Van Wagoner, D.R.; Balk, E.; Billman, G.E.; Chung, M.; Lands, W.; Leaf, A.; McAnulty, J.; Martens, J.R.; Costello, R.B.; Lathrop, D.A. Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation, 2007, 116, e320-35.
9. De Caterina, R.; Madonna, R.; Zucchi, R.; La Rovere, M.T. Antiarrhythmic effects of omega-3 fatty acids: from epidemiology to bedside. Am. Heart J., 2003, 146, 420-430 (Pubitemid 37086679)
10. Richard, D.; Kefi, K.; Barbe, U.; Bausero, P.; Visioli, F. Polyunsaturated fatty acids as antioxidants. Pharmacol. Res., 2008, 57, 451-455
11. DeFilippis, A.P.; Sperling, L.S. Understanding omega-3's. Am. Heart J., 2006, 151, 564-570.
12. Colussi, G.; Catena, C.; Baroselli, S.; Nadalini, E.; Lapenna, R.; Chiuch, A.; Sechi, L.A. Omega-3 fatty acids: from biochemistry to their clinical use in the prevention of cardiovascular disease. Recent Pat. Cardiovasc. Drug Discov., 2007, 2, 13-21. (Pubitemid 46813411)
13. Robinson, J.G.; Stone, N.J. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am. J. Cardiol., 2006, 98(4A), 39i-49i.
14. Reiffel, J.A.; McDonald, A. Anti-arrhythmic effects of omega-3 fatty acids. Am. J. Cardiol., 2006, 98(4A), 50i-60i. (Pubitemid 44223364)
15. Simopoulos, A.P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood), 2008, 233, 674-688
16. Kris-Etherton, P.M.; Taylor, D.S.; Yu-Poth, S.; Huth, P.; Moriarty, K.; Fishell, V.; Hargrove, R.L.; Zhao, G.; Etherton, T.D. Polyunsaturated fatty acids in the food chain in the United States. Am. J. Clin. Nutr., 2000, 71, 179S-88.
17. Mori, T.; Beilin, L. Omega-3 fatty acids and inflammation. Curr. Atheroscler. Rep., 2004, 6, 461-467.
18. Weber, P.; Fischer, S.; von Shacky, C.; Lorenz, R.; Strasser, T. The conversion of dietary eicosopentaenoic acid to prostanoids and leukotrienes in man. Prog. Lipid Res., 1986, 25, 273-276.
19. Li, Y.; Kang, J.; Leaf, A. Differential effects of various eicosanoids on the contraction of cultured neonatal rat cardiomyocytes. Prostaglandins, 1997, 54, 511-530.
20. Cadler, P.C. n-3 Polyunsaturated fatty acids, inflammation, and inflammatory Diseases. Am. J. Clin. Nutr., 2006, 83 (suppl), 1505S-19S.
21. Serhan, C.N.; Arita, M.; Hong, S.; Gotlinger, K. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids, 2004, 39, 1125-1132
22. Fickl, H.; Cockeran, R.; Steel, H.C.; Feldman, C.; Cowan, G.; Mitchell, T.J.; Anderson, R. Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. Clin. Exp. Immunol., 2005, 140, 274-281. (Pubitemid 40559153)
23. Meffert, M.K.; Chang, J.M.; Wiltgen, B.J.; Fanselow, M.S.; Baltimore, D. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci., 2003, 6, 1072-1078. (Pubitemid 37186199)
24. Serhan, C.N.; Clish, C.B.; Brannon, J.; Colgan, S.P.; Gronert, K.; Chiang, N. Anti-inflammatory lipid signals generated from dietary n-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and n-3 PUFA therapeutic actions. J. Physiol. Pharmacol., 2000, 4, 643-654 (Pubitemid 32049518)
25. Serhan, C.N.; Clish, C.B.; Brannon, J.; Colgan, S.P.; Chiang, N.; Gronert, K. Novel functional sets of lipid-derived mediators with antinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal anti-inflammatory drugs and transcellular processing. J. Exp. Med., 2000, 192, 1197-1204 (Pubitemid 30786697)
26. Serhan, C.N.; Hong, S.; Gronert, K.; Colgan, S.P.; Devchand, P.R.; Mirick, G.; Moussignac, R.L. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals. J. Exp. Med., 2002, 196, 1025-1037
27. Hong, S.; Gronert, K.; Devchand, P.; Moussignac, R-L.; Serhan, C.N. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells: autocoids in antiinflammation. J. Biol. Chem., 2003, 278, 14677-14687
28. Marcheselli, V.L.; Hong, S.; Lukiw, W.J.; Tian, X.H.; Gronert, K.; Musto, A.; Hardy, M.; Gimenez, J.M.; Chiang, N.; Serhan, C.N.; Bazan, N.G. Novel docosanoids inhibit brain ischemia reperfusion-mediated leukocyte infiltration and proinflammatory gene expression. J. Biol. Chem., 2003, 278, 43807-43817
29. Mukherjee, P.K.; Marcheselli, V.L.; Serhan, C.N.; Bazan N.G. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl. Acad. Sci. USA, 2004, 101, 8491-8496 (Pubitemid 38736602)
30. Serhan, C.N. Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiol. Clin., 2006, 24, 341-364.
31. Micallef, M.A.; Garg, M.L. Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. Atherosclerosis, 2009, 204(2), 476-482
32. Wang, S.; Wu, D.; Matthan, N.R.; Lamon-Fava, S.; Lecker, J.L.; Lichtenstein, A.H. Reduction in dietary omega-6 polyunsaturated fatty acids: Eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse. Atherosclerosis, 2008, Sep 2 [Epub ahead of print].
33. De Caterina, R.; Madonna, R.; Massaro, M. Effects of omega-3 fatty acids on cytokines and adhesion molecules. Curr. Atheroscler. Rep., 2004, 6, 485-491 (Pubitemid 39585674)
34. Miles, E.A.; Thies, F.; Wallace F.A. Influence of age and dietary fish oil on plasmas soluble adhesion molecule concentrations. Clin. Sci., 2001, 100, 91-100.
35. Baumann, K.H.; Hessel, F.; Larass, I. Dietary w-3, w-6, and w-9 unsaturated fatty acids and growth factor and cytokine gene expression in unstimulated and stimulated monocytes. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 59-66.
36. Sperling, R.I.; Benincaso, A.I.; Knoell, C.T.; Larkin, J.K.; Austen, K.F.; Robinson, D.R. Dietary w-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J. Clin. Invest., 1993, 91, 651-660
37. Libby, P. Inflammation in atherosclerosis. Nature, 2002, 420, 868-874
38. Massaro, M.; Basta, G.; Lazzerini G. Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesis. Thromb. Haemost., 2002, 88, 335-344 (Pubitemid 34873718)
39. Varming, K.; Schmidt E.B.; Svaneborg, N. The effect of n-3 fatty acids on neutrophil chemiluminescence. Scand. J. Clin. Lab. Invest., 1995, 55, 47-52.
40. Thompson, P.J.; Misso, N.L.A.; Passarelli, M.; Phillips, M.J. The effect of eicosapentaenoic acid consumption on human neutrophil chemiluminescence. Lipid, 1991, 26, 1223-1226
41. Luostarinen, R.; Saldeen, T. Dietary fish oil decreases superoxide generation by human neutrophils: relation to cyclooxygenase pathway and lysosomal enzyme release. Prostaglandin Leukot. Essent. Fatty Acids, 1996, 55, 167-172 (Pubitemid 26366834)
42. De Caterina, R.; Cybulsky, M.I.; Clinton, S.K.; Gimbrone, M.A.; Libby, P. The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. Arterioscler. Thromb., 1994, 14, 1829-1836 (Pubitemid 2164792)
43. De Caterina, R.; Bernini, W.; Carluccio, M.A.; Liao, J.K.; Libby, P. Structural requirements for inhibition of cytokine-induced endothelial activation by unsaturated fatty acids. J. Lipid Res., 1998, 39, 1062-1070 (Pubitemid 28222012)
44. Matsumoto, M.; Sata, M.; Fukuda, D.; Tanaka, K.; Soma, M.; Hirata, Y.; Nagai, R. Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice. Atherosclerosis, 2008, 197, 524-533
45. Thies, F.; Garry, J.M.; Yaqoob, P.; Rerkasem, K.; Williams, J.; Shearman, C.P.; Gallagher, P.J.; Calder, P.C.; Grimble, R.F. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomized controlled trial. Lancet, 2003, 361, 477-485.
46. Brown, A.A.; Hu F.B. Dietary modulation of endothelial function: implications for cardiovascular disease. Am. J. Clin. Nutr., 2001, 73, 673-686. (Pubitemid 32239221)
47. Nestel, P.; Shige, H.; Pomeroy, S.; Cehun, M.; Abbey, M.; Raederstorff, D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am. J. Clin. Nutr., 2002, 76, 326-330. (Pubitemid 34804052)
48. Harris, W.S.; Rambjor, G.; Windsor, S.; Diederich, D. n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans. Am. J. Clin. Nutr., 1997, 65, 459-464.
49. Schiano, V.; Laurenzano, E.; Brevetti, G.; De Maio, J.I.; Lanero, S.; Scopacasa, F.; Chiariello, M. Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function. Clin. Nutr., 2008, 27, 241-247
50. Park, Y.; Harris, W. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J. Lipid Res., 2003, 44, 455-463. (Pubitemid 37279692)
51. Chan, D.C.; Watts, G.F.; Barrett, P.H.; Beilin, L.J.; Redgrave, T.G.; Mori, T.A. Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia. Diabetes, 2002, 51, 2377-2386.
52. Connor, W. The impact of dietary omega-3 fatty acids on the synthesis and clearance of apo B lipoproteins and chylomicrons: Proceedings of the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular Biology, and Medicine, American Heart Association, Houston, TX; April 17-19, 1994.
53. Colussi, G.L.; Baroselli, S.; Sechi L.A. w-3 polyunsaturated fatty acids decrease plasma lipoprotein(a) levels in hypertensive subjects. Clin. Nutr., 2004, 23, 1246-1247
54. Elvevoll, E.O.; Eilertsen, K.E.; Brox, J.; Dragnes, B.T.; Falkenberg, P.; Olsen, J.O.; Kirkhus, W.; Lamglait, A.; Østerud, B. Seafood diets: hypolipidemic and anti-atherogenic effects of taurine and n-3 fatty acids. Atherosclerosis, 2008, 200, 396-402.
55. Jayasooriya, A.P.; Begg, D.P.; Chen, N.; Mathai, M.L.; Sinclair, A.J.; Wilkinson-Berka, J.; Wark, J.D.; Weisinger, H.S.; Weisinger R.S. Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats. Prostaglandins Leukot. Essent. Fatty Acids, 2008, 78, 67-72.
56. Geleijnse, J.M.; Giltay, E.J.; Grobbee, D.E.; Donders, A.R.; Kok, F.J. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J. Hypertens., 2002, 20,1493-1499.
57. Garman, J.H.; Mulroney, S.E.; Manigrasso, M.; Flynn, E.; Maric, C. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am. J. Physiol. Renal Physiol., 2009, 296(2), F306-16.
58. Perassolo, M.S.; Almeida, J.C.; Steemburgo, T.; Dall'Alba, V.; de Mello, V.D.; Zelmanovitz, T.; de Azevedo, M.J.; Gross J.L. Endothelial dysfunction and serum fatty acid composition in patients with type 2 diabetes mellitus. Metabolism, 2008, 57, 1167-1172
59. Lefevre, M.; Kris-Etherton, P.M.; Zhao, G.; Tracy R.P. Dietary fatty acids, hemostasis, and cardiovascular disease risk. J. Am. Diet. Assoc., 2004, 104, 410-419. (Pubitemid 38296639)
60. Hjerkinn, E.M.; Seljeflot, I.; Ellingsen, I.; Berstad, P.; Hjermann, I.; Sandvik, L.; Arnesen, H. Influence of long-term intervention with dietary counseling, long-chain n-3 fatty acid supplements, or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia. Am. J. Clin. Nutr., 2005, 81, 583-589.
61. Vanschoonbeek, K.; Wouters, K.; van der Meijden, P.E.; van Gorp, P.J.; Feijge, M.A.; Herfs, M.; Schurgers, L.J.; Hofker, M.H.; de Maat, M.P.; Heemskerk, J.W. Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice. Arterioscler. Thromb. Vasc. Biol., 2008, 28, 2023-2029
62. Nordoy, A.; Bonaa, K.H.; Sandset, P.M. Effect of omega-3 fatty acids and simvastatin on hemostatic risk factors and postprandial hyperlipemia in patients with combined hyperlipemia. Arterioscler. Thromb. Vasc. Biol., 2000, 20, 259-265
63. Berecki, G.; Den Ruijter, H.M.; Verkerk, A.O.; Schumacher, C.A.; Baartscheer, A.; Bakker, D.; Boukens, B.J.; van Ginneken, A.C.; Fiolet, J.W.; Opthof, T.; Coronel, R. Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes. Heart Rhythm, 2007, 4, 1452-1460 (Pubitemid 47578526)
64. Den Ruijter, H.M.; Berecki, G.; Opthof, T.; Verkerk, A.O.; Zock, P.L.; Coronel, R. Pro- and anti-arrhythmic properties of a diet rich in fish oil. Cardiovasc. Res., 2007, 73, 316-325
65. Cheng, J.W.; Santoni, F. Omega-3 fatty acid: a role in the management of cardiac arrhythmias? J. Altern. Complement. Med., 2008, 14, 965-974
66. Kinoshita, I.; Itoh, K.; Nishida-Nakai, M.; Hirota, H.; Otsuji, S.; Shibata, N. Anti-arrhythmic effects of eicosapentaenoic acid during myocardial infarction- enhanced cardiac microsomal (Ca(2+)-Mg2+)-ATPase activity. Jpn. Circ. J., 1994, 58, 903-912.
67. Anderson, K.E.; Du, X.J.; Sinclair, A.J.; Woodcock, E.A.; Dart, A.M. Dietary fish oil prevents reperfusion Ins(1,4,5)P3 release in rat heart: possible anti-arrhythmic mechanism. Am. J. Physiol., 1996, 271, H1483-H1490. (Pubitemid 126833705)
68. Owen, A.J.; Peter-Przyborowska, B.A.; Hoy, A.J.; McLennan, P.L. Dietary fish oil dose- and time-response effects on cardiac phospholipid fatty acid composition. Lipids, 2004, 39, 955-961. (Pubitemid 40095878)
69. Yang, B.; Saldeen, T.G.; Nichols, W.W.; Mehta, J.L. Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts. J. Nutr., 1993, 123, 2067-2074. (Pubitemid 24020730)
70. Ma, D.W.; Seo, J.; Switzer, K.C.; Fan, Y.Y.; McMurray, D.N.; Lupton, J.R.; Chapkin, R.S. n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research. J. Nutr. Biochem., 2004, 15, 700-706.
71. Billman, G.E.; Kang, J.X.; Leaf, A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation, 1999, 99, 2452-2457. (Pubitemid 29218243)
72. Geelen, A.; Zock, P.L.; Brouwer, I.A.; Katan, M.B.; Kors, J.A.; Ritsema van Eck, H.J.; Schouten, E.G. Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes. Br. J. Nutr., 2005, 93, 787-790.
73. Leaf, A.; Kang, J.X.; Xiao, Y.F.; Billman, G.E. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation, 2003, 107, 2646-2652. (Pubitemid 36667234)
74. Leaf, A. The electrophysiological basis for the anti-arrhythmic actions of polyunsaturated fatty acids. Eur. Heart J. Suppl., 2001, (Suppl D), D98-D105. (Pubitemid 33713208)
75. Leaf, A.; Xiao, Y.F.; Kang, J.X.. Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias. J. Membr. Biol., 2005, 206, 129-139
76. Ma, J.Y.; Catterall, W.A.; Scheuer, T. Persistent sodium currents through brain sodium channels induced by G protein beta gamma subunits. Neuron, 1997, 19, 443-452 (Pubitemid 27374241)
77. Kang, J.X.; Li, Y.; Leaf, A. Regulation of sodium channel gene expression by class I anti-arrhythmic drugs and n-3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. USA, 1997, 94, 2724-2728. (Pubitemid 27136944)
78. McLennan, P.; Howe, P.; Abeywardena, M.; Muggli, R.; Raederstorff, D.; Mano, M.; Rayner, T.; Head, R. The cardiovascular protective role of docosahexaenoic acid. Eur. J. Pharmacol., 1996, 300, 83- 89.
79. Rouzaire-Dubois, B.; Gerard, V.; Dubois, JM. Modification of K+ channel properties induced by fatty acids in neuroblastoma cells. Pflugers. Arch., 1991, 419, 467-471.
80. Macleod, J.C.; Macknight, A.D.C.; Rodrigo, G.C. The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega-3 polyunsaturated fatty acids. Eur. J. Pharmacol., 1998, 356, 261-270 (Pubitemid 28439140)
81. Jude, S.; Bedut, S.; Roger, S.; Pinault, M.; Champeroux, P.; White, E.; Le Guennec, J.Y. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. Br. J. Pharmacol., 2003, 139, 816-822.
82. Xu, X.P.; Erichsen, D.; Börjesson, S.I.; Dahlin, M.; Amark, P.; Elinder, F. Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action. Epilepsy Res., 2008, 80, 57-66.
83. Börjesson, S.I.; Hammarström, S.; Elinder, F. Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids. Biophys J., 2008, 95, 2242-2253
84. Xiao, Y.F.; Gomez, A.M.; Morgan, J.P.; Lederer, W.J.; Leaf, A. Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc. Natl. Acad. Sci. USA, 1997, 94, 4182-4187 (Pubitemid 27180520)
85. Ferrier, G.R.; Redondo, I.; Zhu, J.; Murphy, M.G. Differential effects of docosahexaenoic acid on contractions and L-type Ca2+ current in adult cardiac myocytes. Cardiovasc. Res., 2002, 54, 601-610
86. Verkerk, A.O.; van Ginneken, A.C.G.; Berecki, G.; Den Ruijter, H.M.; Schumacher, C.A.; Veldkamp, M.W.; Baartscheer, A.; Casini, S.; Opthof, T.; Hovenier, R.; Fiolet, J.W.; Zock, P.L.; Coronel, R. Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials. Cardiovasc. Res., 2006, 70, 509-520
87. Leaf, A. The electrophysiologic basis for the anti-arrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain. Lipids, 2001, 36(Suppl), S107-S110. (Pubitemid 34106218)
88. Negretti, N.; Perez, M.R.; Walker, D.; O'Neill, S.C. Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. J. Physiol., 2000, 523, 367-375.
89. Honen, B.N.; Saint, D.A.; Laver, D.R. Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid. J. Membr. Biol., 2003,196,95-103.
90. Swan, J.S.; Dibb, K.; Negretti, N.; O'Neill, S.C.; Sitsapesan, R. Effects of eicosapentaenoic acid on cardiac SR Ca(2+)-release and ryanodine receptor function. Cardiovasc. Res., 2003, 60, 337-346. (Pubitemid 37412367)
91. Leifert, W.R.; Dorian, C.L.; Jahangiri, A.; McMurchie, E.J. Dietary fish oil prevents asynchronous contractility and alters Ca(2+) handling in adult rat cardiomyocytes. J. Nutr. Biochem., 2001, 12, 365-376.
92. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet, 1999, 354, 447-455.
93. Marchioli, R.; Barzi, F.; Bomba, E.; Chieffo, C.; Di Gregorio, D.; Di Mascio, R.; Franzosi, M.G.; Geraci, E.; Levantesi, G.; Maggioni, A.P. Early protection against sudden death by omega-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation, 2002, 105, 1897-1903.
94. Gissi-HF Investigators; Tavazzi, L.; Maggioni, A.P.; Marchioli, R.; Barlera, S.; Franzosi, M.G.; Latini, R.; Lucci, D.; Nicolosi, G.L.; Porcu, M.; Tognoni, G.Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet, 2008, 372, 1223-1230
95. Whelton, S.P.; He, J.; Whelton, P.K. Meta-analysis of observational studies on fish intake and coronary heart disease. Am. J. Cardiol., 2004, 93, 1119-1123 (Pubitemid 38521040)
96. He, K.; Song, Y.; Daviglus, M.L.; Liu, K.; Van Horn, L.; Dyer, A.R.; Greenland, P. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation, 2004, 109, 2705-2711 (Pubitemid 38737914)
97. Zhao, Y.T.; Chen, Q.; Sun, Y.X.; Li, X.B.; Zhang, P.; Xu, Y.; Guo, J.H. Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. Ann. Med., 2009, 41, 301-310
98. Yzebe, D.; Lievre, M. Fish oils in the care of coronary heart disease patients: a meta-analysis of randomized controlled trials. Fundam. Clin. Pharmacol., 2004, 18, 581-592 (Pubitemid 39468967)
99. Bucher, H.C.; Hengstler, P.; Schindler, C. N-3 polyunstaurated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am. J. Med., 2002, 112, 298-304. (Pubitemid 34219443)
100. Hooper, L.; Thompson, R.L.; Harrison, R.A. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst. Rev., 2004, 4, CD003177.
101. Schmitz, G.; Ecker, J. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipid Res., 2008, 47, 147-155
102. Fer, M.; Corcos, L.; Dréano, Y.; Plée-Gautier, E.; Salaün, J.P.; Berthou, F.; Amet, Y. Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism. J. Lipid Res., 2008, 49, 2379-2389
103. Macchia, A.; Monte, S.; Pellegrini, F.; Romero, M.; Ferrante, D.; Doval, H.; D'Ettorre, A.; Maggioni, A.P.; Tognoni, G. Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction. Eur. J. Clin. Pharmacol., 2008, 64, 627-634