Xenobiotic-induced recruitment of autoantigens to nuclear proteasomes suggests a role for altered antigen processing in scleroderma

Annals of the New York Academy of Sciences

Volumn 1051, Issue , 2005, Pages 382-389

  Chen, Min ^a   Von Mikecz, Anna ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Antigen processing; Nuclear autoantigens; Proteasomes; Scleroderma

Indexed keywords

ANTIGEN; ANTINEOPLASTIC AGENT; AUTOANTIGEN; CAMPTOTHECIN; CELL NUCLEUS ANTIGEN; FIBRILLARIN; HEAVY METAL; HORMONE; INORGANIC SALT; MERCURIC CHLORIDE; NANOPARTICLE; ORGANIC SOLVENT; PLATINUM DERIVATIVE; PROTEASOME; SILICON DIOXIDE; TOPOTECAN; XENOBIOTIC AGENT;

ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL NUCLEUS; CONFERENCE PAPER; DISEASE MODEL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; HUMAN; IDIOPATHIC DISEASE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; RISK FACTOR; SCLERODERMA; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALIA;

EID: 25444497458     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1361.080     Document Type: Conference Paper

References (34)

1. JACOBSON, D.L., S.J. GANGE, N.R. ROSE & N.M. GRAHAM. 1997. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol. 84: 223-243.
2. TAMBY, M.C., Y. CHANSEAUD, L. GUILLEVIN & L. MOUTHON. 2003. New insights into the pathogenesis of systemic sclerosis. Autoimmun. Rev. 2: 152-157.
3. TAN, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44: 93-151.
4. ROTHHELD, N.F. 1992. Autoantibodies in scleroderma. Rheum. Dis. Clin. North Am. 18: 483-498.
5. TAN, E.M. 1991. Autoantibodies in pathology and cell biology. Cell 67: 841-842.
6. SILMAN, A.J. & M.C. HOCHBERG. 1996. Occupational and environmental influences on scleroderma. Rheum. Dis. Clin. North Am. 22: 737-749.
7. HULTMAN, P., S. ENESTROM, K.M. POLLARD & EM. TAN. 1989. Anti-fibrillarin antibodies in mercury-treated mice. Clin. Exp. Immunol. 78: 470-477.
8. REUTER, R. et al. 1989. Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Proc. Natl. Acad. Sci. USA 86: 237-241.
9. POLLARD, K.M. et al. 1997. The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J. Immunol. 158: 3521-3528.
10. LEE, B. & J.E. CRAFT. 1995. Molecular structure and function of autoantigens in systemic sclerosis. Int. Rev. Immunol. 12: 129-144.
11. ARNETT, F.C. et al. 1996. Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis. Arthritis Rheum. 39: 1151-1160.
12. HAUSTEIN, U.F. & V. ZIEGLER. 1985. Environmentally induced systemic sclerosis-like disorders. Int. J. Dermatol. 24: 147-151.
13. Fox, R.I. & H.I. KANG. 1992. Genetic and environmental factors in systemic sclerosis. Curr. Opin. Rheumatol. 4: 857-861.
14. YEWDELL, J.W. & J.R. BENNINK. 1990. The binary logic of antigen processing and presentation to T cells. Cell 62: 203-206.
15. GERMAIN, R.N. & D.H. MARGULIES. 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11: 403-450.
16. ALBERT, M.L. et al. 1998. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188: 1359-1368.
17. GUERMONPREZ, P. et al. 2003. ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature 425: 397-402.
18. HOUDE, M. et al. 2003. Phagosomes are competent organelles for antigen cross-presentation. Nature 425: 402-406.
19. LEHNER, P.J. & P. CRESSWELL. 2004. Recent developments in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol. 16: 82-89.
20. MALNATI, M.S. et al. 1992. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature 357: 702-704.
21. MUNZ, C. et al. 2000. Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J. Exp. Med. 191: 1649-1460.
22. REED, R.C. & C.V. NICCHITTA. 2000. Chaperone-mediated cross-priming: a hitch-hiker's guide to vesicle transport. Int. J. Mol. Med. 6: 259-264.
23. HEATH, W.R. & F.R. CARBONE. 2001. Cross-presentation in viral immunity and self-tolerance. Nature Rev. Immunol. 1: 126-134.
24. ROCKEL, T. & A. VON MIKECZ. 2002. Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization. J. Struct. Biol. 140: 189-199.
25. CHEN, M. & A. VON MIKECZ. 2000. Specific inhibition of rRNA transcription and dynamic re-location of fibrillarin induced by mercury. Exp. Cell Res. 259: 225-238.
26. CHEN, M. et al. 2002. Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. Mol. Biol. Cell 13: 3576-3587.
27. DESAI, S.D., L.F. LIU, D. VAZQUEZ-ABAD & P. D'ARPA. 1997. Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J. Biol. Chem. 272: 24159-24164.
28. CHEN, M. et al. 2005. Recruitment of topoisomerase I (Scl-70) to nucleoplasmic proteasomes in response to xenobiotics suggests a role for altered antigen processing in scleroderma. Arthritis Rheum. 52: 877-884.
29. CHEN, M., P. HEMMERICH & A. VON MIKECZ. 2002. Platinum-induced autoantibodies target nucleoplasmic antigens related to active transcription. Immunobiology 206: 474-483.
30. LOMONTE, P., K.F. SULLIVAN & R.D. EVERETT. 2001. Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. J. Biol. Chem. 276: 5829-5835.
31. CHEN, M. & A. VON MIKECZ. 2005. Proteasomal processing of nuclear autoantigens in systemic autoimmunity. Autoimmun. Rev. 4: 117-122.
32. VON MIKECZ, A. & P. HEMMERICH. 2004. Subnuclear pathology. In Visions of the Cell Nucleus. P. Hemmeiich & S. Diekmann, Eds.: 184-203. American Scientific Publishers. Stevenson Ranch, CA.
33. VON MIKECZ, A. 2005. Xenobiotic-induced autoimmunity and protein aggregation diseases share a common subnuclear pathology. Autoimmun. Rev. 4: 214-218.
34. 2 nanoparticles. Exp. Cell Res. 305: 51-62.