The formation constants of mercury(II)-glutathione complexes

Chemical Research in Toxicology

Volumn 9, Issue 4, 1996, Pages 709-712

  Oram, Paul D ^a   Fang, Xiaojun ^a,c   Fernando, Quintus ^a   Letkeman, Peter ^b   Letkeman, Douglas ^b  

^a University of Arizona   (United States)

^b BRANDON UNIVERSITY   (Canada)

^c Dept of Pharmacology and Toxicology ^*

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDOTE; EDETIC ACID; GLUTATHIONE; LIGAND; MERCURY; PENTETIC ACID; POTASSIUM HYDROXIDE;

ARTICLE; COMPLEX FORMATION; DISSOCIATION CONSTANT; IONIC STRENGTH; LIGAND BINDING; MERCURIALISM; PKA; POTENTIOMETRY; PROTON TRANSPORT; TITRIMETRY;

BINDING, COMPETITIVE; CHELATING AGENTS; COUNTERCURRENT DISTRIBUTION; GLUTATHIONE; LIGANDS; MERCURY; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; PENTETIC ACID; POTENTIOMETRY;

EID: 0029943553     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9501896     Document Type: Article

References (21)

1. Stricks, W., and Kolthoff, I. M. (1953) Reactions between mercuric mercury and cysteine and glutathione. Apparent dissociation constants, heats and entropies of formation of various forms of mercuric mercaptocysteine and -glutathione. J. Am. Chem. Soc. 75, 5673-5681.
2. 2+ and alkali. Biochim. Biophys. Acta 100, 376-383.
3. Fuhr, B. J., and Rabentstein, D. L. (1973) Nuclear magnetic resonance studies of the solution chemistry of metal complexes. IX. The binding of cadmium, zinc, lead, and mercury by glutathione. J. Am. Chem. Soc. 95, 6944-6950.
4. Neville, G. A., and Drakenberg, T. (1974) Mercuric mercury and methylmercury complexes of glutathione. Acta Chem. Scand. B 28, 473-477.
5. Katōno, Y., Inoue, Y., and Chûjô, R. (1977) Nuclear magnetic resonance studies of the complex formation of mercuric chloride with L-cysteine and with glutathione. Polymer J. 9, 471-478.
6. 3 complexes and Hg(II)-thiol ligand exchange kinetics. J. Am. Chem. Soc. 110, 6359-6364.
7. Shoukry, M. M., Cheesman, B. V., and Rabentstein, D. L. (1988) Polarimetric and nuclear magnetic resonance studies of the complexation of mercury by thiols. Can. J. Chem. 66, 3184-3189.
8. Casas, J. S., and Jones, M. M. (1980) Mercury(II) complexes with sulfhydryl containing chelating agents: stability constant inconsistencies and their resolution. J. Inorg. Nucl. Chem. 42, 99-102.
9. Fang, X., Hua, F., and Fernando, Q. (1996) Comparison of racand meso-2,3-dimercaptosuccinic acid (DMSA) for mobilizing mercury and cadmium using chemical speciation models. Chem. Res. Toxicol. 9, 284-290.
10. Ackermann, H., and Schwarzenbach, G. (1949) Complexones XVI. The Determination of Formation Constants of Highly Stable Complexes of the Iminodiacetic Acid Derivatives. Helv. Chim. Acta 32, 1543-1554.
11. Přibil, R. (1982) Applied Complexometry, Pergamon Press, Oxford.
12. Harris, W. R., and Martell, A. E. (1976) Aqueous complexes of gallium(III). Inorg. Chem. 15, 713-720.
13. Motekaitis, R. J., and Martell, A. E. (1982) BEST-A new program for rigorous calculation of equilibrium parameters of complex multicomponent systems. Can. J. Chem. 60, 2403-2409.
14. Martell, A. E., and Motekaitis, R. J. (1988) Determination and Use of Stability Constants, VCH, New York.
15. Gran, G. (1950) Determination of the equivalent point in potentiometric titrations. Acta Chem. Scand. 4, 559-577.
16. Gran, G. (1952) Determination of the equivalence point in potentiometric titrations. Part II. Analyst 77, 661-671.
17. Rossotti, F. J. C., and Rossotti, H. (1965) Potentiometric titrations using Gran plots. J. Chem. Educ. 42, 375-378.
18. Rabenstein, D. L. (1973) Nuclear magnetic resonance studies of the acid-base chemistry of amino acids and peptides. I. Microscopic methylmercury-complesed glutathione. J. Am. Chem. Soc. 95, 2797-2803.
19. Pillai, L., Boss, R. D., and Greenberg, M. S. (1979) On the role of solvent in complexation equilibria. II. The acid-base chemistry of some sulfhydryl and ammonium containing amino acids in water-acetonitrile mixed solvents. J. Solution Chem. 8, 635-646.
20. Arnold, A. P., and Canty, A. J. (1983) Methylmercury(II)sulfydryl interactions. Potentiometric determination of the formation constants for complexation of methylmercury(II) by sulfhydryl containing amino acids and related molecules, including glutathione. Can. J. Chem. 61, 1428-1434.
21. Kotrlý, S., and Šůcha, L. (1985) Handbook of Chemical Equilibria in Analytical Chemistry, Ellis Horwood Ltd., Chichester.