Murine mercury-induced autoimmunity. A model of chemically related autoimmunity in humans

Immunologic Research

Volumn 20, Issue 1, 1999, Pages 67-78

  Bagenstose, Lee M ^b   Salgame, Padmini ^a   Monestier, Marc ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Animal model; Autoimmunity; Cytokines; Fibrillarin; Heavy metal; Mercury; Nucleolus; Scleroderma

Indexed keywords

AUTOANTIGEN; HEAVY METAL; IMMUNOGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MERCURY;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; GLOMERULONEPHRITIS; HELPER CELL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; REVIEW;

EID: 0032769558     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786508     Document Type: Review

References (92)

1. 1 Klassen CD: Toxicology. The Basic Science of Poisons, 5th ed. New York, McGraw-Hill, 1996.
2. 2 Arena JM, Drew RH: Poisoning. Toxicology. Symptoms. Treatments, 5th ed. Springfield, Charles C. Thomas, 1986.
3. 3 Graef JW: Heavy metal poisoining, in Harrison's Principles of Internal Medicine, Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds.). New York, McGraw-Hill, 1994-2461.
4. 4 Gritzka TL, Trump BF: Renal tubular lesions caused by mercuric chloride. Am J Pathol 1968; 52:1225-1250.
5. 5 Bariety J, Druet P, Laliberte F, Sapin C: Glomerulonephritis with γ-and ßIC-globulin deposits induced in rats by mercurie chloride. Am J Pathol 1971;65:293-302.
6. 6 Sapin C, Druet E, Druet P: Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride. Clin Exp Immunol 1977; 28:173-179.
7. 7 Mathieson PW: Mercuric chloride-induced autoimmunity. Autoimmunity 1992;13:243-247.
8. 8 Goldman M, Druet P, Gleichmann E: TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol Today 1991;12:223-227.
9. 9 Pusey CD, Bowman C, Morgan A, Weetman AP, Hartley B, Lockwood CM: Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the Brown Norway rat. Clin Exp Immunol 1990;81:76-82.
10. 10 Marriott JB, Qasim F, Oliveira DB: Anti-phospholipid antibodies in the mercuric chloride treated brown Norway rat. J Autoimmunity 1994;7:457-467.
11. 11 Robinson CJG, Balazs T, Egorov IK: Mercuric chloride-, gold sodium thiomalate-, and D-penicillamine-induced antinuclear antibodies in mice. Toxicol Appl Pharmacol 1986;86:159-169.
12. 12 Hultman P, Enestrom S, Pollard KM, Tan EM: Anti-fibrillarin antibodies in mercury-treated mice. Clin Exp Immunol 1989;78:470-477.
13. 13 Reuter R, Tessars G, Vohr HW, Gleichmann E, Luhrmann R: Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Proc Natl Acad Sci USA 1989;86:237-241.
14. S mice. J Immunol 1994;152:667-675.
15. 15 Hultman P, Turley SJ, Enestrom S, Lindh U, Pollard KM: Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmunity 1996;9: 139-146.
16. 16 Bowman C, Mason DW, Pusey CD, Lockwood CM: Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat. I. A role for T suppressor cells. Eur J Immunol 1984;14:464-470.
17. 17 Mathieson PW, Stapleton KJ, Oliveira DB, Lockwood CM: Immunoregulation of mercuric chloride-induced autoimmunity in Brown Norway rats: a role for CD8+ T cells revealed by in vivo depletion studies. Eur J Immunol 1991;21: 2105-2109.
18. 18 Castedo M, Pelletier L, Rossert J, Pasquier R, Villarroya H, Druet P: Mercury-induced autoreactive anticlass II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. J Exp Med 1993;177:881-889.
19. 19 Pelletier L, Rossert J, Pasquier R, Vial MC, Druet P: Role of CD8+ T cells in mercury-induced autoimmunity or immunosuppression in the rat. Scand J Immunol 1990;31: 65-74.
20. 20 Hanley GA, Schiffenbauer J, Sobel ES: Resistance to HgCl2-induced autoimmunity in haplotype-heterozygous mice is an intrinsic property of B cells. J Immunol 1998; 161:1778-1785.
21. 21 Druet E, Sapin C, Gunther E, Feingold N, Druet P: Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur J Immunol 1997;7:348-351.
22. 22 Sapin C, Mandet C, Druet E, Gunther E, Druet P: Immune complex type disease induced by HgCl2 in Brown-Norway rats: genetic control of susceptibility. Clin Exp Immunol 1982;48:700-704.
23. 23 Aten J, Veninga A, de Heer E, Rozing J, Nieuwenhuis P, Hoedemaeker PJ, et al.: Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur J Immunol 1991;21:611-616.
24. 24 Goter Robinson CJ, White HJ, Rose NR: Murine strain differences in response to mercuric chloride: Antinucleolar antibodies production does not correlate with renal immune complex deposition. Clin Immunol Immunopathol 1997;83:127-138.
25. 25 Goter Robinson CJ, Abraham AA, Balazs T: Induction of anti-nuclear antibodies by mercuric chloride in mice. Clin Exp Immunol 1984;58: 300-306.
26. 2-induced antinucleolar antibodies. Eur J Immunol 1989;19:2257-2261.
27. 27 Hultman P, Bell LJ, Enestrom S, Pollard KM: Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin Immunol Immunopathol 1992;65:98-109.
28. 28 Hultman P, Bell LJ, Enestrom S, Pollard KM: Murine susceptibility to mercury. II. autoantibody profiles and renal immune deposits in hybrid, backcross, and H-2d congenic mice. Clin Immunol Immunopathol 1993;68:9-20.
29. 2-treated mice. Clin Immunol Immunopathol 1997;84:328-337.
30. 30 Biancone L, Andres G, Ahn H, Lim A, Dai C, Noelle R, et al.: Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease. J Exp Med 1996; 183:1473-1481.
31. 31 Molina A, Sanchez-Madrid F, Bricio T, Martin A, Barat A, Alvarez V, et al.: Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin. J Immunol 1994;153:2313-2320.
32. 32 Hultman P, Johansson U, Turley SJ, Lindh U, Enestrom S, Pollard KM: Adverse immunological effects and autoimmunity induced by dental amalgam and alloy in mice. FASEB J 1994;8:1183-1190.
33. 33 Hultman P, Enestrom S, Turley SJ, Pollard KM: Selective induction of anti-fibrillarin autoantibodies by silver nitrate in mice. Clin Exp Immunol 1994;96:285-291.
34. 34 Schuhmann D, Kubicka-Muranyi M, Mirtschewa J, Gunther J, Kind P, Gleichmann E: Adverse immune reactions to gold. I. Chronic treatment with an Au(I) drug sensitizes mouse T cells not to Au(I), but to Au(III) and induces autoantibody formation. J Immunol 1990;145: 2132-2139.
35. 35 Ohsawa M, Takahashi K, Otsuka F: Induction of anti-nuclear antibodies in mice orally exposed to cadmium at low concentrations. Clin Exp Immunol 1988;73:98-102.
36. 36 Monestier M, Novick KE, Losman MJ: D-penicillamine-and quinidine-induced antinuclear antibodies in A.SW (H-2s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity. Eur J Immunol 1994;24: 723-730.
37. 37 Satoh M, Hamilton KJ, Ajmani AK, Dung X, Wang J, Kanwar YS, et al.: Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane. J Immunol 1996;157:3200-3206.
38. 38 Musmann TR, Coffman RL: Differing patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
39. 39 Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, et al.: Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991;254:279-282.
40. H1 cells. Immunol Today 1993;14: 335-338.
41. 41 Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348.
42. 42 Hultman P, Johansson U, Dagnaes-Hansen F: Murine mercury-induced autoimmunity: The role of T-helper cells. J Autoimmunity 1995;8:809-823.
43. 43 Prigent P, Saoudi A, Pannetier C, Graber P, Bonnefoy J-Y, Druel P, et al.: Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in Brown Norway rats, directly triggers T cells to produce interleukin-4. J Clin Invest 1995;96: 1484-1489.
44. 44 Oliveira DB, Gillespie K, Wolfreys K, Mathieson PW, Qasim F, Coleman JW: Compounds that induce autoimmunity in the Brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression. Eur J Immunol 1995; 25:2259-2264.
45. 45 Van der Meide PH, de Labie MC, Botman CA, van Bennekom WP, Olsson T, Aten J, et al.: Mercuric chloride down-regulates T cell interferon-gamma production in brown Norway but not in Lewis rats; role of glutathione. Eur J Immunol 1993;23:675-681.
46. 46 Mathieson PW, Thiru S, Oliveira DB: Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat. J Exp Med 1993;177:1309-1316.
47. 47 van Vliet E, Uhrberg M, Stein C, Gleichmann E: MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int Arch Allergy Immunol 1993;101:392-401.
48. 48 Bagenstose LM, Salgame P, Monestier M: IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J Immunol 1998;160:1612-1617.
49. d mice is mediated by interferon-gamma (IFN-gamma). Clin Exp Immunol 1997; 109:149-156.
50. 50 Ochel M, Vohr HW, Pfeiffer C, Gleichmann E: IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J Immunol 1991;146:3006-3011.
51. 51 Bagenstose LM, Salgame P, Monestier M: Mercury-induced autoimmunity in the absence of interleukin-4. Clin Exp Immunol 1998; 114:9-12.
52. 52 Kono DH, Balomenos D, Pearson DL, Park MS, Hildebrandt B, Hultman P, et al.: The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-γ and not Th1/ Th2 imbalance. J Immunol 1998; 161:234-240.
53. 53 Hultman P, Ganowiak K, Turley SJ, Pollard KM: Genetic susceptibility to silver-induced antifibrillarin autoantibodies in mice. Clin Immunol Immunopathol 1995; 77:291-297.
54. 54 Johansson U, Hansson-Georgiadis H, Hultman P: Murine silver-induced autoimmunity: silver shares induction of antinucle-olar antibodies with mercury, but causes less activation of the immune system. Int Arch Allergy Immunol 1997;113: 432-443.
55. 55 Jiang Y, Moller G: In vitro effects of HgCl2 on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder strain. J Immunol 1995;154.3138-3146.
56. 56 Hultman P, Enestrom S: The induction of immune complex deposits in mice by peroral and parenteral administration of mercuric chloride: strain dependent susceptibility. Clin Exp Immunol 1987;67: 283-292.
57. 57 Stiller-Winkler R, Radaszkiewicz T, Gleichmann E: Immunopathological signs in mice treated with mercury compounds - I. Identification by the popliteal lymph node assay of responder and nonresponder strains. Int J Immunopharmacol 1988;10:475-484.
58. 58 Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology 1997;90:198-204.
59. 2) on human mononuclear cells. Clin Exp Immunol 1997;110:418-422.
60. 60 Pelletier L, Pasquier R, Guettier C, Vial MC, Mandet C, Nochy D, et al.: HgCl2 induces T and B cells to proliferate and differentiate in BN rats. Clin Exp Immunol 1988; 71:336-342.
61. 2 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol 1982;12:620-625.
62. 62 Hu H, Moller G, Abedi-Valugerdi M: Major histocompatibilily complex class II antigens are required for both cytokine production and proliferation induced by mercuric chloride in vitro. J Autoimmunity 1997;10:441-446.
63. 63 Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmunity 1997;10:347-355.
64. 2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent calcium influx through L-type calcium channels. J Biol Chem 1997; 272:32,411-32,418.
65. 65 Meister A, Anderson ME: Glutathione. Annu Rev Biochem 1983; 52:711-760.
66. 66 Jeannin P, Delneste Y, Lecoanet-Henchoz S, Gauchat JF, Life P, Holmes D, et al.: Thiols decrease human interleukin (IL) 4 production and [L-4-induced immunoglobulin synthesis. J Exp Med 1995;182:1785-1792.
67. 67 Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C: Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 1998;95:3071-3076.
68. 68 Hu H, Moller G, Abedi-Valugerdi M: Thiol compounds inhibit mercury-induced immunological and immunopathological alterations in susceptible mice. Clin Exp Immunol 1997;107:68-75.
69. 69 Ochs RL: Methods used to study structure and function of the nucleolus. Methods Cell Biol 1998;53: 303-321.
70. 70 Rosen A, Casciola-Rosen L: Environmental determinants of autoimmune disease, in The Autoimmune Diseases. Rose NR, Mackay IR (eds.). San Diego, Academic, 1998, p. 119.
71. 71 Griem P, Gleichmann E: Metal ion induced autoimmunity. Current Opinion Immunol 1995;7: 831-838.
72. 72 Griem P, Panthel K, Kalbacher H, Gleichmann E: Alteration of a model antigen by Au(III) leads to T cell sensitization to cryptic peptides. Eur J Immunol 1996;26: 279-287.
73. 73 Kubicka-Muranyi M, Griem P, Lubben B, Rottmann N, Luhrmann R, Gleichmann E: Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int Arch Allergy Immunol 1995; 108:1-10.
74. 74 Kubicka-Muranyi M, Kremer J, Rottmann N, Lubben B, Albers R, Bloksma N, Luhrmann R, Gleichmann E: Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self-proteins. Int Arch Allergy Immunol 1996;109:11-20.
75. 75 Goyer RA: Environmentally related diseases of the urinary tract. Med Clin North Am 1990; 74:377-389.
76. 76 Enestrom S, Hultman P: Does amalgam affect the immune system? A controversial issue. Int Arch Allergy Immunol 1995;106: 180-203.
77. 77 Röger J, Zillikens D, Hartmann AA, Burg G, Gleichmann E: Systemic autoimmune disease in a patient with long-standing exposure to mercury. Eur J Dermatol 1992;2:168-170, 1992.
78. 78 Moszczynski P, Slowinski S, Rutkowski J, Bem S, Jakus-Stoga D: Lymphocytes, T and NK cells, in men occupationally exposed to mercury vapours. Int J Occupational Med Environ Health 1995;8:49-56.
79. 79 Cardenas A, Roels H, Bernard AM, Barbon R, Buchet JP, Rosello J, et al.: Markers of early renal changes induced by industrial pollutants. I. Application to workers exposed to mercury vapors. Br J Ind Med 1998;50:17-27.
80. 80 Dantas DC, Queiroz ML: Immunoglobulin E and autoantibodies in mercury-exposed workers. Immunopharmacol Immunotoxicol 1997;19:383-392.
81. 81 Warfvinge K, Hansson H, Hultman P: Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose-response studies. Toxicol Appl Pharmacol 1995; 132:299-309.
82. 82 Lorscheider FL, Vimy MJ, Summers AO: Mercury exposure from "silver" tooth fillings: emerging evidence questions a traditional dental paradigm. FASEB J 1995; 9:504-508.
83. 83 Kilburn KH, Warshaw RH: Prevalence of symptoms of systemic lupus erythematosus (SLE) and of fluorescent antinuclear antibodies associated with chronic exposure to trichloroethylene and other chemicals in well water. Environ Res 1992;57:1-9.
84. 84 Monestier M, Kotzin BL: Antibodies to histones in systemic lupus erythematosus and drug-induced lupus syndromes. Rheum Dis Clin North Am 1992;18: 415-436.
85. 85 Rothfield NF: Autoantibodies in scleroderma. Rheum Dis Clin North Am 1992;18:483-498.
86. 86 Silman AJ: Epidemiology of scleroderma. Ann Rheum Dis 1991; 50:846-853.
87. 87 Monestier M: Nucleolar autoantibodies, in Autoantibodies. Peter JB, Shoenfeld Y (eds.). Amsterdam, Elsevier, 1996, p. 567.
88. 88 Takeuchi K, Turley SJ, Tan EM, Pollard KM: Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity. J Immunol 1995 ;154:961-971.
89. 89 Arnett FC, Reveille JD, Goldstein R, Pollard KM, Leaird K, Smith EA, et al.: Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis. Arthritis Rheum 1996;39:1151-1160.
90. 90 Mavilia C, Scaletti C, Romagnani P, Carossino A, Pignone A, Emmi, et al.: Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis. Am J Pathol 1997;151:1571-1578.
91. 91 Bigazzi P: Autoimmunity induced by chemicals. Clin Toxicol 1988; 26:125-156.
92. 92 Gleichmann E, Kimber I, Purchase IFH: Immunotoxicology: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system. Arch Toxicol 1989; 63: 257-273.